Publications by authors named "Rory Brito"

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Evaluation of a strategy to enhance the efficacy and ease of application of porcine reproductive and respiratory syndrome virus vaccines.
Antonella Schiavone, Jane C Edwards, Easha Vigneswaran, Rory C F De Brito, Harkeerat Hothi

Vaccine· October 2025

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A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate.
Rory C F de Brito, Yashar Sadigh, Joseph Bowman, Stephanie Clive, Ben Jackson

NPJ Vaccines· June 2025

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CD4 and CD8 T-cell multi-epitope chimeric protein associated with an MPLA adjuvant induce protective efficacy and long-term immunological memory for the immunoprophylaxis of American Tegumentary Leishmaniasis.
Dênia Monteiro de Moura, Ana Maria Ravena Severino Carvalho, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt, Daniela Pagliara Lage

Vaccine· August 2024

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Ivabradine restores tonic cardiovascular autonomic control and reduces tachycardia, hypertension and left ventricular inflammation in post-weaning protein malnourished rats.
Mariana Reis Guedes, Sylvana Izaura Salyba Rendeiro de Noronha, Máira Tereza Talma Chírico, Gabriela Dias Carvalho da Costa, Thalles de Freitas Castro, Rory Cristiane Fortes de Brito

Life Sci· June 2024

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Synthetic Peptides Selected by Immunoinformatics as Potential Tools for the Specific Diagnosis of Canine Visceral Leishmaniasis.
Gabriel Moreira, Rodrigo Maia, Nathália Soares, Thais Ostolin, Wendel Coura-Vital, Rory de Brito

Microorganisms· April 2024

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An attenuated herpesvirus vectored vaccine candidate induces T-cell responses against highly conserved porcine reproductive and respiratory syndrome virus M and NSP5 proteins that are unable to control infection.
Rory C F de Brito, Kerry Holtham, Jessica Roser, Jack E Saunders, Yvonne Wezel

Front Immunol· February 2024

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Oropouche virus infection induces ROS production and oxidative stress in liver and spleen of mice.
Marília Bueno da Silva Menegatto, Ariane Coelho Ferraz, Rafaela Lameira Souza Lima, Letícia Trindade Almeida, Rory Cristiane Fortes de Brito, Cintia Lopes de Brito Magalhães

J Gen Virol· May 2023

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ASP-2/Trans-sialidase chimeric protein induces robust protective immunity in experimental models of Chagas' disease.
Julia T Castro, Rory Brito, Natalia S Hojo-Souza, Bárbara Azevedo, Natalia Salazar

NPJ Vaccines· May 2023

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The Use of an Adjuvant System Improves Innate and Adaptive Immune Response When Associated with a () Antigen in a Vaccine Candidate against () Infection.
Fernando Augusto Siqueira Mathias, Thais Lopes Valentim Di Paschoale Ostolin, Levi Eduardo Soares Reis, Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes De Brito

Vaccines (Basel)· February 2023

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CD4 T-lymphocytes from asymptomatic dogs infected with Leishmania infantum are able to activate macrophages for higher leishmanicidal ability in an in vitro co-culture experiment.
João Filipe Pereira Vieira, Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt, Cláudia Martins Carneiro

Mol Immunol· November 2022

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Immunoprophylaxis using polypeptide chimera vaccines plus adjuvant system promote Th1 response controlling the spleen parasitism in hamster model of visceral leishmaniasis.
Miriã Rodrigues Gusmão, Thaís Lopes Valentim Di Paschoali Ostolin, Lívia Mendes Carvalho, Ana Flávia Pereira Costa, Gabriel José Lucas Moreira, Rory Cristiane Fortes de Brito

Vaccine· September 2022

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Development of an immunogen containing CD4/CD8 T-cell epitopes for the prophylaxis of tegumentary leishmaniasis.
Isabela de Andrade Ferraz, Ana Maria Ravena Severino Carvalho, Rory Cristiane Fortes de Brito, Bruno Mendes Roatt, Vívian Tamietti Martins

Appl Microbiol Biotechnol· June 2022

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Immunochemotherapy for visceral leishmaniasis: combinatorial action of Miltefosine plus LBSapMPL vaccine improves adaptative Th1 immune response with control of splenic parasitism in experimental hamster model.
Lívia Mendes Carvalho, Miriã Rodrigues Gusmão, Ana Flávia Pereira Costa, Rory Cristiane Fortes de Brito, Rodrigo Dian de Oliveira Aguiar-Soares

Parasitology· March 2022

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Comparative evaluation of meglumine antimoniate encapsulated in a mixture of conventional and PEGylated liposomes and immunotherapy using an anti-canine IL-10 receptor-blocking monoclonal antibody on canine visceral leishmaniasis.
Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, João Filipe Pereira Vieira

Mol Immunol· January 2022

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Heterologous vaccine therapy associated with half course of Miltefosine promote activation of the proinflammatory response with control of splenic parasitism in a hamster model of visceral leishmaniasis.
Lívia Mendes Carvalho, Francielle Carvalho Ferreira, Miriã Rodrigues Gusmão, Ana Flávia Pereira Costa, Rory Cristiane Fortes de Brito

Curr Res Immunol· November 2021

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IL-10 receptor blockade controls the in vitro infectivity of Leishmania infantum and promotes a Th1 activation in PBMC of dogs with visceral leishmaniasis.
Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito, Ana Flávia Pereira Costa, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis

Mol Immunol· September 2021

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Acarbose presents in vitro and in vivo antileishmanial activity against Leishmania infantum and is a promising therapeutic candidate against visceral leishmaniasis.
Rafaella R Costa, João A Oliveira-da-Silva, Thiago A R Reis, Grasiele S V Tavares, Débora V C Mendonça, Rory C F Brito

Med Microbiol Immunol· June 2021

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A chimeric vaccine combined with adjuvant system induces immunogenicity and protection against visceral leishmaniasis in BALB/c mice.
Thais Lopes Valentim Di Paschoale Ostolin, Miriã Rodrigues Gusmão, Fernando Augusto Siqueira Mathias, Jamille Mirelle de Oliveira Cardoso, Bruno Mendes Roatt, Rory Cristiane Fortes de Brito

Vaccine· May 2021

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Establishment of monoclonal antibodies to evaluate the cellular immunity in a hamster model of L infantum infection.
Lívia Mendes Carvalho, Rory Cristiane Fortes de Brito, Miriã Rodrigues Gusmão, Rodrigo Dian de Oliveira Aguiar-Soares, Alexandre Barbosa Reis

Parasite Immunol· April 2021

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In vitro and in vivo antileishmanial activity of β-acetyl-digitoxin, a cardenolide of Digitalis lanata potentially useful to treat visceral leishmaniasis.
Camila S Freitas, Daniela P Lage, João A Oliveira-da-Silva, Rafaella R Costa, Débora V C Mendonça, Rory C F Brito

Parasite· April 2021

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Ivermectin presents effective and selective antileishmanial activity in vitro and in vivo against Leishmania infantum and is therapeutic against visceral leishmaniasis.
Thiago A R Reis, João A Oliveira-da-Silva, Grasiele S V Tavares, Débora V C Mendonça, Camila S Freitas, Rory C F Brito

Exp Parasitol· February 2021

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Digitoxigenin presents an effective and selective antileishmanial action against Leishmania infantum and is a potential therapeutic agent for visceral leishmaniasis.
Camila S Freitas, João A Oliveira-da-Silva, Daniela P Lage, Rafaella R Costa, Débora V C Mendonça, Rory C F Brito

Parasitol Res· January 2021

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Liver infusion tryptose (LIT): the best choice for growth, viability, and infectivity of Leishmania infantum parasites.
Ana Flávia Pereira Costa, Rory Cristiane Fortes de Brito, Lívia Mendes Carvalho, Jamille Mirelle de Oliveira Cardoso, Paula Melo de Abreu Vieira

Parasitol Res· December 2020

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Recent advances and new strategies on leishmaniasis treatment.
Bruno Mendes Roatt, Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes De Brito, Wendel Coura-Vital, Rodrigo Dian de Oliveira Aguiar-Soares

Appl Microbiol Biotechnol· November 2020

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Phase I and II Clinical Trial Comparing the LBSap, Leishmune, and Leish-Tec Vaccines against Canine Visceral Leishmaniasis.
Rodrigo Dian de Oliveira Aguiar-Soares, Bruno Mendes Roatt, Fernando Augusto Siqueira Mathias, Levi Eduardo Soares Reis, Jamille Mirelle de Oliveira Cardoso, Rory Cristiane Fortes de Brito

Vaccines (Basel)· November 2020

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