Publications by authors named "Rosa Luo"

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Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants.
Rosa Luo, Ajay Madan, Christine T Ferrara-Cook, Deepak Dalvie, Lance Goulet

Br J Clin Pharmacol· July 2025

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A hybrid IA-LC-MS/MS method for adrenocorticotropic hormone(1-24) to support interpretation of low-dose cosyntropin-stimulation test.
Barry R Jones, Junlong Shao, Mitesh Sanghvi, Alejandro Ayala, Rosa Luo

Bioanalysis· September 2024

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Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.
Sun Hee Kim, Sangdon Han, Jian Zhao, Shimiao Wang, Ana Karin Kusnetzow, Rosa Luo

ACS Med Chem Lett· April 2024

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2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in Rare Matrices, Complex NAb Assays, Spectral Cytometry, Endogenous Analytes, Extracellular Vesicles - Recommendations on Biomarkers/CDx, Flow Cytometry, Ligand-Binding Assays Development & Validation; Emerging Technologies; Critical Reagents Deep Characterization.
Giane Sumner, Steve Keller, James Huleatt, Roland F Staack, Leslie Wagner, Rosa Luo, Linlin Luo

Bioanalysis· August 2023

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ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly.
Monica R Gadelha, Murray B Gordon, Mirjana Doknic, Emese Mezősi, Miklós Tóth, Rosa Luo

J Clin Endocrinol Metab· April 2023

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Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.
Jian Zhao, Shimiao Wang, Stacy Markison, Sun Hee Kim, Sangdon Han, Rosa Luo

ACS Med Chem Lett· January 2023

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Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism.
Jian Zhao, Shimiao Wang, Sun Hee Kim, Sangdon Han, Elizabeth Rico-Bautista, Rosa Luo

Bioorg Med Chem Lett· September 2022

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Efficacy of Vesicular Monoamine Transporter 2 Inhibition and Synergy with Antipsychotics in Animal Models of Schizophrenia.
Samuel R J Hoare, Andrea E Kudwa, Rosa Luo, Dimitri E Grigoriadis

J Pharmacol Exp Ther· May 2022

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Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers.
Ajay Madan, Stacy Markison, Stephen F Betz, Alan Krasner, Rosa Luo

Pituitary· April 2022

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Single Dose and Repeat Once-Daily Dose Safety, Tolerability and Pharmacokinetics of Valbenazine in Healthy Male Subjects.
Rosa Luo, Haig Bozigian, Roland Jimenez, Gordon Loewen, Christopher F O'Brien

Psychopharmacol Bull· August 2017

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Single-Dose Study of a Corticotropin-Releasing Factor Receptor-1 Antagonist in Women With 21-Hydroxylase Deficiency.
Adina F Turcu, Joanna L Spencer-Segal, Robert H Farber, Rosa Luo, Dimitri E Grigoriadis

J Clin Endocrinol Metab· March 2016

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Vascular effects of urocortins 2 and 3 in healthy volunteers.
Sowmya Venkatasubramanian, Megan E Griffiths, Steven G McLean, Mark R Miller, Rosa Luo

J Am Heart Assoc· January 2013

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Validation and application of a liquid chromatography-tandem mass spectrometric method for the simultaneous determination of testosterone and dihydrotestosterone in rat prostatic tissue using a 96-well format.
Zhihong O'Brien, Noah Post, Michael Brown, Ajay Madan, Timothy Coon, Rosa Luo

J Chromatogr B Analyt Technol Biomed Life Sci· November 2009

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A novel on-line solid-phase extraction approach integrated with a monolithic column and tandem mass spectrometry for direct plasma analysis of multiple drugs and metabolites.
Xu Zang, Rosa Luo, Ning Song, Ta Kung Chen, Haig Bozigian

Rapid Commun Mass Spectrom· March 2006

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