Publications by authors named "Rosa Spinelli"

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Senotherapeutics for metabolic disease and diabetic complications.
Allyson K Palmer, Rosa Spinelli, Larissa G Langhi Prata, Selim Chaib, Masayoshi Suda

J Intern Med· January 2026

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Physical training reduces cell senescence and associated insulin resistance in skeletal muscle.
Agnieszka Podraza-Farhanieh, Rosa Spinelli, Federica Zatterale, Annika Nerstedt, Silvia Gogg

Mol Metab· May 2025

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Hypomethylation at PANDAR promoter progressively induces senescence in adipocyte precursor cells in subjects with obesity and type 2 diabetes.
Antonella Desiderio, Monica Pastorino, Michele Campitelli, Immacolata Prevenzano, Fatima Domenica Elisa De Palma, Rosa Spinelli

FASEB J· October 2024

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Altered H3K4me3 profile at the TFAM promoter causes mitochondrial alterations in preadipocytes from first-degree relatives of type 2 diabetics.
Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo

Clin Epigenetics· September 2023

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The Transcription Factor : Novel Insights into Metabolic Diseases and Adipose Tissue Dysfunction.
Luca Parrillo, Rosa Spinelli, Michele Longo, Federica Zatterale, Gianluca Santamaria

Cells· August 2023

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Increased cell senescence in human metabolic disorders.
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Blüher

J Clin Invest· June 2023

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Methylglyoxal Impairs the Pro-Angiogenic Ability of Mouse Adipose-Derived Stem Cells (mADSCs) via a Senescence-Associated Mechanism.
Alessia Leone, Antonella Nicolò, Immacolata Prevenzano, Federica Zatterale, Michele Longo, Rosa Spinelli

Cells· June 2023

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Type 2 Diabetes, Independent of Obesity and Age, Is Characterized by Senescent and Dysfunctional Mature Human Adipose Cells.
Birgit Gustafson, Annika Nerstedt, Rosa Spinelli, Francesco Beguinot, Ulf Smith

Diabetes· November 2022

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Chronic hyperinsulinemia promotes human hepatocyte senescence.
Ritesh K Baboota, Rosa Spinelli, Malin C Erlandsson, Bruna B Brandao, Marsel Lino

Mol Metab· October 2022

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ZMAT3 hypomethylation contributes to early senescence of preadipocytes from healthy first-degree relatives of type 2 diabetics.
Rosa Spinelli, Pasqualina Florese, Luca Parrillo, Federica Zatterale, Michele Longo

Aging Cell· March 2022

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Epigenetic Dysregulation of the () Gene Associates with Subcutaneous Adipocyte Hypertrophy in Human Obesity.
Luca Parrillo, Rosa Spinelli, Mattia Costanzo, Pasqualina Florese, Serena Cabaro

Cells· February 2022

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Adipocyte precursor cells from first degree relatives of type 2 diabetic patients feature changes in hsa-mir-23a-5p, -193a-5p, and -193b-5p and insulin-like growth factor 2 expression.
Paola Mirra, Antonella Desiderio, Rosa Spinelli, Cecilia Nigro, Michele Longo

FASEB J· April 2021

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Altered DNA methylation associates with restricted adipogenesis in healthy first-degree relatives of Type 2 diabetes subjects.
Luca Parrillo, Rosa Spinelli, Michele Longo, Antonella Desiderio, Paola Mirra

Epigenomics· May 2020

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KCTD1: A novel modulator of adipogenesis through the interaction with the transcription factor AP2α.
Luciano Pirone, Giovanni Smaldone, Rosa Spinelli, Manlio Barberisi, Francesco Beguinot

Biochim Biophys Acta Mol Cell Biol Lipids· December 2019

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Epigenetic silencing of the ANKRD26 gene correlates to the pro-inflammatory profile and increased cardio-metabolic risk factors in human obesity.
Antonella Desiderio, Michele Longo, Luca Parrillo, Michele Campitelli, Giuseppe Cacace, Rosa Spinelli

Clin Epigenetics· December 2019

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Nutritional Factors, DNA Methylation, and Risk of Type 2 Diabetes and Obesity: Perspectives and Challenges.
Luca Parrillo, Rosa Spinelli, Antonella Nicolò, Michele Longo, Paola Mirra

Int J Mol Sci· June 2019

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Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.
Cecilia Nigro, Alessia Leone, Michele Longo, Immacolata Prevenzano, Thomas H Fleming, Rosa Spinelli

Biochim Biophys Acta Mol Basis Dis· January 2019

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Prep1 Deficiency Affects Olfactory Perception and Feeding Behavior by Impairing BDNF-TrkB Mediated Neurotrophic Signaling.
Serena Ricci, Davide Viggiano, Ilaria Cimmino, Giuseppe Perruolo, Serena Cabaro, Rosa Spinelli

Mol Neurobiol· August 2018

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Citrus aurantium L. dry extracts promote C/ebpβ expression and improve adipocyte differentiation in 3T3-L1 cells.
Gregory Alexander Raciti, Francesca Fiory, Michele Campitelli, Antonella Desiderio, Rosa Spinelli

PLoS One· June 2018

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Prep1 deficiency improves metabolic response in white adipose tissue.
Antonietta Liotti, Serena Cabaro, Ilaria Cimmino, Serena Ricci, Claudio Procaccini, Rosa Spinelli

Biochim Biophys Acta Mol Cell Biol Lipids· May 2018

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Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity.
Michele Longo, Gregory A Raciti, Federica Zatterale, Luca Parrillo, Antonella Desiderio, Rosa Spinelli

Diabetologia· February 2018

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Targetting PED/PEA-15 for diabetes treatment.
Francesca Fiory, Rosa Spinelli, Gregory Alexander Raciti, Luca Parrillo, Vittoria D'esposito

Expert Opin Ther Targets· June 2017

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Specific CpG hyper-methylation leads to Ankrd26 gene down-regulation in white adipose tissue of a mouse model of diet-induced obesity.
Gregory A Raciti, Rosa Spinelli, Antonella Desiderio, Michele Longo, Luca Parrillo

Sci Rep· March 2017

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Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.
Michele Longo, Rosa Spinelli, Vittoria D'Esposito, Federica Zatterale, Francesca Fiory

Biochim Biophys Acta· June 2016

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Adipose microenvironment promotes triple negative breast cancer cell invasiveness and dissemination by producing CCL5.
Vittoria D'Esposito, Domenico Liguoro, Maria Rosaria Ambrosio, Francesca Collina, Monica Cantile, Rosa Spinelli

Oncotarget· April 2016

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