Publications by authors named "Ross Fredenburg"

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Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies.
Ruth D Azaria, Adele B Correia, Kylie J Schache, Manuela Zapata, Koralege C Pathmasiri, Ross A Fredenburg

JCI Insight· August 2024

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Correction to "Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD)".
Bharat Lagu, Arthur F Kluge, Effie Tozzo, Ross Fredenburg, Eric L Bell

ACS Med Chem Lett· June 2019

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PPARδ modulation rescues mitochondrial fatty acid oxidation defects in the mdx model of muscular dystrophy.
Eric L Bell, Robert W Shine, Peter Dwyer, Lyndsay Olson, Jennifer Truong, Ross Fredenburg

Mitochondrion· May 2019

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Selective PPARδ Modulators Improve Mitochondrial Function: Potential Treatment for Duchenne Muscular Dystrophy (DMD).
Bharat Lagu, Arthur F Kluge, Effie Tozzo, Ross Fredenburg, Eric L Bell

ACS Med Chem Lett· September 2018

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Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Bharat Lagu, Arthur F Kluge, Matthew M Goddeeris, Effie Tozzo, Ross A Fredenburg

Bioorg Med Chem Lett· February 2018

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Novel highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulators with pharmacokinetic properties suitable for once-daily oral dosing.
Bharat Lagu, Arthur F Kluge, Ross A Fredenburg, Effie Tozzo, Ramesh S Senaiar

Bioorg Med Chem Lett· December 2017

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Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
Alan R Jacobson, Michael Adler, Nicholas R Silvaggi, Karen N Allen, Genessa M Smith, Ross A Fredenburg

Toxicon· October 2017

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Development and advanced validation of an optimized method for the quantitation of Aβ42 in human cerebrospinal fluid.
Valerie C Cullen, Ross A Fredenburg, Cindy Evans, Phyllis R Conliffe, Michael E Solomon

AAPS J· September 2012

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Botulinum neurotoxin serotype A inhibitors: small-molecule mercaptoacetamide analogs.
Scott T Moe, Andrew B Thompson, Genessa M Smith, Ross A Fredenburg, Ross L Stein

Bioorg Med Chem· April 2009

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Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease.
Zhihua Liu, Robin K Meray, Tom N Grammatopoulos, Ross A Fredenburg, Mark R Cookson

Proc Natl Acad Sci U S A· March 2009

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.
Katerina E Paleologou, Adrian W Schmid, Carla C Rospigliosi, Hai-Young Kim, Gonzalo R Lamberto, Ross A Fredenburg

J Biol Chem· June 2008

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Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.
Marta Martinez-Vicente, Zsolt Talloczy, Susmita Kaushik, Ashish C Massey, Joseph Mazzulli, Ross Fredenburg

J Clin Invest· February 2008

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The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.
Ross A Fredenburg, Carla Rospigliosi, Robin K Meray, Jeffrey C Kessler, Hilal A Lashuel

Biochemistry· June 2007

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy.
Ana Maria Cuervo, Leonidas Stefanis, Ross Fredenburg, Peter T Lansbury, David Sulzer

Science· August 2004

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