Publications by authors named "Rossa Chiu"

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Rossa W K Chiu

Am J Hum Genet· December 2025

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Rossa W K Chiu

Am J Hum Genet· May 2025

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Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs.
Ze Zhou, Mary-Jane L Ma, Rebecca W Y Chan, W K Jacky Lam, Wenlei Peng, Rossa W K Chiu

Proc Natl Acad Sci U S A· April 2023

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Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma.
Stephanie C Y Yu, Jiaen Deng, Rong Qiao, Suk Hang Cheng, Wenlei Peng, Rossa W K Chiu

Clin Chem· February 2023

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Fragment Ends of Circulating Microbial DNA as Signatures for Pathogen Detection in Sepsis.
Guangya Wang, W K Jacky Lam, Lowell Ling, Mary-Jane L Ma, Saravanan Ramakrishnan, Rossa W K Chiu

Clin Chem· February 2023

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Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W K Jacky Lam, Rossa W K Chiu

Proc Natl Acad Sci U S A· November 2022

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Single-Molecule Sequencing Enables Long Cell-Free DNA Detection and Direct Methylation Analysis for Cancer Patients.
L Y Lois Choy, Wenlei Peng, Peiyong Jiang, Suk Hang Cheng, Stephanie C Y Yu, Rossa W K Chiu

Clin Chem· September 2022

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The Next Frontier in Noninvasive Prenatal Diagnostics: Cell-Free Fetal DNA Analysis for Monogenic Disease Assessment.
Lilian Pok Wa Zhong, Rossa W K Chiu

Annu Rev Genomics Hum Genet· August 2022

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Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus.
Spencer C Ding, Rebecca W Y Chan, Wenlei Peng, Liangbo Huang, Ze Zhou, Rossa W K Chiu

Clin Chem· July 2022

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Fragmentomics of urinary cell-free DNA in nuclease knockout mouse models.
Meihui Chen, Rebecca W Y Chan, Peter P H Cheung, Meng Ni, Danny K L Wong, Rossa W K Chiu

PLoS Genet· July 2022

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Effects of nucleases on cell-free extrachromosomal circular DNA.
Sarah Tk Sin, Jiaen Deng, Lu Ji, Masashi Yukawa, Rebecca Wy Chan, Rossa Wk Chiu

JCI Insight· April 2022

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High-resolution analysis for urinary DNA jagged ends.
Tingting Xie, Guangya Wang, Spencer C Ding, Wing-Shan Lee, Suk Hang Cheng, Rossa W K Chiu

NPJ Genom Med· February 2022

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Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.
Stephanie C Y Yu, Peiyong Jiang, Wenlei Peng, Suk Hang Cheng, Y T Tommy Cheung, Rossa W K Chiu

Proc Natl Acad Sci U S A· December 2021

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Single Cell and Plasma RNA Sequencing for RNA Liquid Biopsy for Hepatocellular Carcinoma.
Joaquim S L Vong, Lu Ji, Macy M S Heung, Suk Hang Cheng, John Wong, Rossa W K Chiu

Clin Chem· November 2021

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Nuclease deficiencies alter plasma cell-free DNA methylation profiles.
Diana S C Han, Meng Ni, Rebecca W Y Chan, Danny K L Wong, Linda T Hiraki, Rossa W K Chiu

Genome Res· November 2021

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Cell-free fetal DNA coming in all sizes and shapes.
Rossa W K Chiu, Y M Dennis Lo

Prenat Diagn· September 2021

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Dissection of Aberration for Cervical Adenocarcinoma Outcomes.
Tony K H Chung, Graeme Doran, Tak-Hong Cheung, So-Fan Yim, Mei-Yung Yu, Rossa W K Chiu

Cancers (Basel)· June 2021

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Characteristics of Fetal Extrachromosomal Circular DNA in Maternal Plasma: Methylation Status and Clearance.
Sarah T K Sin, Lu Ji, Jiaen Deng, Peiyong Jiang, Suk Hang Cheng, Rossa W K Chiu

Clin Chem· April 2021

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Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies.
Y M Dennis Lo, Diana S C Han, Peiyong Jiang, Rossa W K Chiu

Science· April 2021

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Jagged Ends of Urinary Cell-Free DNA: Characterization and Feasibility Assessment in Bladder Cancer Detection.
Ze Zhou, Suk Hang Cheng, Spencer C Ding, Macy M S Heung, Tingting Xie, Peter K F Chiu, Rossa W K Chiu

Clin Chem· March 2021

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Applications of genetic-epigenetic tissue mapping for plasma DNA in prenatal testing, transplantation and oncology.
Wanxia Gai, Ze Zhou, Sean Agbor-Enoh, Xiaodan Fan, Sheng Lian, Rossa Wk Chiu

Elife· March 2021

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Fetal mitochondrial DNA in maternal plasma in surrogate pregnancies: Detection and topology.
Mary-Jane L Ma, Sergey Yakovenko, Haiqiang Zhang, Suk Hang Cheng, Valentina Apryshko, Rossa W K Chiu

Prenat Diagn· February 2021

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Genome-wide detection of cytosine methylation by single molecule real-time sequencing.
O Y Olivia Tse, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, Huimin Shang, Rossa W K Chiu

Proc Natl Acad Sci U S A· February 2021

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Cell-Free DNA Fragmentomics: The New "Omics" on the Block.
Rossa W K Chiu, Ellen Heitzer, Y M Dennis Lo, Florent Mouliere, Dana W Y Tsui

Clin Chem· December 2020

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Rossa W K Chiu

Am J Hum Genet· November 2020

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