Publications by authors named "Wenlei Peng"

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Wenlei Peng

Am J Hum Genet· December 2025

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Chromatin accessibility states affect transrenal clearance of plasma DNA: Implications for urine-based diagnostics.
Mary-Jane L Ma, Woody Z Zhang, Peiyong Jiang, Lu Ji, Dongyan Xiong, Wenlei Peng

Med· July 2025

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Wenlei Peng

Am J Hum Genet· May 2025

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Transformer-based deep learning for accurate detection of multiple base modifications using single molecule real-time sequencing.
Xi Hu, Yuwei Shi, Suk Hang Cheng, Zhaoyang Huang, Ze Zhou, Wenlei Peng

Commun Biol· April 2025

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Analysis of a cell-free DNA-based cancer screening cohort links fragmentomic profiles, nuclease levels, and plasma DNA concentrations.
Yasine Malki, Guannan Kang, W K Jacky Lam, Qing Zhou, Suk Hang Cheng, Wenlei Peng

Genome Res· January 2025

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Methylation-Associated Nucleosomal Patterns of Cell-Free DNA in Cancer Patients and Pregnant Women.
Guanhua Zhu, Peiyong Jiang, Xingqian Li, Wenlei Peng, L Y Lois Choy

Clin Chem· November 2024

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Genomic origin, fragmentomics, and transcriptional properties of long cell-free DNA molecules in human plasma.
Huiwen Che, Peiyong Jiang, L Y Lois Choy, Suk Hang Cheng, Wenlei Peng

Genome Res· March 2024

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Droplet digital PCR is a cost-effective method for analyzing long cell-free DNA in maternal plasma: Application in preeclampsia.
Wanxia Gai, Stephanie C Y Yu, W T Charlotte Chan, Wenlei Peng, So Ling Lau

Prenat Diagn· October 2023

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Effects of Capsaicin on Glucose Uptake and Consumption in Hepatocytes.
Haolong Zeng, Nian Shi, Wenlei Peng, Qing Yang, Jingnan Ren

Molecules· July 2023

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Fragmentation landscape of cell-free DNA revealed by deconvolutional analysis of end motifs.
Ze Zhou, Mary-Jane L Ma, Rebecca W Y Chan, W K Jacky Lam, Wenlei Peng

Proc Natl Acad Sci U S A· April 2023

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Comparison of Single Molecule, Real-Time Sequencing and Nanopore Sequencing for Analysis of the Size, End-Motif, and Tissue-of-Origin of Long Cell-Free DNA in Plasma.
Stephanie C Y Yu, Jiaen Deng, Rong Qiao, Suk Hang Cheng, Wenlei Peng

Clin Chem· February 2023

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Epigenetic analysis of cell-free DNA by fragmentomic profiling.
Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W K Jacky Lam, Wenlei Peng

Proc Natl Acad Sci U S A· November 2022

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Single-Molecule Sequencing Enables Long Cell-Free DNA Detection and Direct Methylation Analysis for Cancer Patients.
L Y Lois Choy, Wenlei Peng, Peiyong Jiang, Suk Hang Cheng, Stephanie C Y Yu

Clin Chem· September 2022

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Jagged Ends on Multinucleosomal Cell-Free DNA Serve as a Biomarker for Nuclease Activity and Systemic Lupus Erythematosus.
Spencer C Ding, Rebecca W Y Chan, Wenlei Peng, Liangbo Huang, Ze Zhou

Clin Chem· July 2022

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Single-molecule sequencing reveals a large population of long cell-free DNA molecules in maternal plasma.
Stephanie C Y Yu, Peiyong Jiang, Wenlei Peng, Suk Hang Cheng, Y T Tommy Cheung

Proc Natl Acad Sci U S A· December 2021

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Jagged Ends of Urinary Cell-Free DNA: Characterization and Feasibility Assessment in Bladder Cancer Detection.
Ze Zhou, Suk Hang Cheng, Spencer C Ding, Macy M S Heung, Tingting Xie, Wenlei Peng

Clin Chem· March 2021

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Genome-wide detection of cytosine methylation by single molecule real-time sequencing.
O Y Olivia Tse, Peiyong Jiang, Suk Hang Cheng, Wenlei Peng, Huimin Shang

Proc Natl Acad Sci U S A· February 2021

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Plasma DNA Profile Associated with DNASE1L3 Gene Mutations: Clinical Observations, Relationships to Nuclease Substrate Preference, and In Vivo Correction.
Rebecca W Y Chan, Lee Serpas, Meng Ni, Stefano Volpi, Linda T Hiraki, Wenlei Peng

Am J Hum Genet· November 2020

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Detection and characterization of jagged ends of double-stranded DNA in plasma.
Peiyong Jiang, Tingting Xie, Spencer C Ding, Ze Zhou, Suk Hang Cheng, Wenlei Peng

Genome Res· August 2020

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Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation.
Peiyong Jiang, Kun Sun, Wenlei Peng, Suk Hang Cheng, Meng Ni

Cancer Discov· May 2020

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Topologic Analysis of Plasma Mitochondrial DNA Reveals the Coexistence of Both Linear and Circular Molecules.
Mary-Jane L Ma, Haiqiang Zhang, Peiyong Jiang, Sarah T K Sin, Wai Kei Jacky Lam, Wenlei Peng

Clin Chem· September 2019

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Methylation analysis of plasma DNA informs etiologies of Epstein-Barr virus-associated diseases.
W K Jacky Lam, Peiyong Jiang, K C Allen Chan, Wenlei Peng, Huimin Shang

Nat Commun· July 2019

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deletion causes aberrations in length and end-motif frequencies in plasma DNA.
Lee Serpas, Rebecca W Y Chan, Peiyong Jiang, Meng Ni, Kun Sun, Wenlei Peng

Proc Natl Acad Sci U S A· January 2019

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Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma.
W K Jacky Lam, Peiyong Jiang, K C Allen Chan, Suk H Cheng, Haiqiang Zhang, Wenlei Peng

Proc Natl Acad Sci U S A· May 2018

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Regulation of plant height in rice by the Polycomb group genes OsEMF2b, OsFIE2 and OsCLF.
Jun Zhong, Zhu Peng, Qinglei Peng, Qingqing Cai, Wenlei Peng

Plant Sci· February 2018

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