Publications by authors named "Rowan Stringer"

Claim this Profile
T
Thiazole-Based IL-17 Inhibitors Discovered by Scaffold Morphing.
Juraj Velcicky, Estelle Ngo, Matthias R Bauer, Arndt Meyer, Achim Schlapbach, Rowan Stringer

ChemMedChem· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors.
Juraj Velcicky, Matthias R Bauer, Achim Schlapbach, Guillaume Lapointe, Arndt Meyer, Rowan Stringer

J Med Chem· September 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Predicting the Intravenous Pharmacokinetics of Covalent Drugs in Animals and Humans.
Rowan Stringer, Tobias Kaster

J Med Chem· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study.
Quentin M Anstee, Kathryn J Lucas, Sven Francque, Manal F Abdelmalek, Arun J Sanyal, Rowan Stringer

Hepatology· October 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.
Rowan Stringer, Jin Chen, Bharti Shah, Jessie Gu, Yiming Zhang

Clin Pharmacol Drug Dev· February 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
J
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRAS for the Treatment of Solid Tumors.
Edwige Lorthiois, Marc Gerspacher, Kim S Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer

J Med Chem· December 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Drug-Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects.
Jin Chen, Rowan Stringer, Bharti Shah, Jessie Gu, Yiming Zhang

Clin Pharmacol Drug Dev· November 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Andreas Weiss, Edwige Lorthiois, Louise Barys, Kim S Beyer, Claudio Bomio-Confaglia, Rowan Stringer

Cancer Discov· June 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment.
Jin Chen, Jessie Gu, Bharti Shah, Rowan Stringer, Leonel Reis da Silva Torrao

J Clin Pharmacol· April 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
Juraj Velcicky, Rainer Wilcken, Simona Cotesta, Philipp Janser, Achim Schlapbach, Rowan Stringer

J Med Chem· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Based and Property-Driven Optimization of -Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
Klemens Hoegenauer, Joerg Kallen, Eloísa Jiménez-Núñez, Ross Strang, Peter Ertl, Rowan Stringer

J Med Chem· December 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice.
Rowan Stringer, Valerie Cordier, Catherine Afatsawo, Philip Arabin, Sandrine Desrayaud

Xenobiotica· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model.
David A Carcache, Anna Vulpetti, Joerg Kallen, Henri Mattes, David Orain, Rowan Stringer

J Med Chem· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to "Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP Receptor Antagonist for Treatment of Asthma".
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Rowan Stringer

ACS Med Chem Lett· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP Receptor Antagonist for Treatment of Asthma.
David A Sandham, Lucy Barker, Lyndon Brown, Zarin Brown, David Budd, Rowan Stringer

ACS Med Chem Lett· May 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.
Christine Guntermann, Alessandro Piaia, Marie-Laure Hamel, Diethilde Theil, Tina Rubic-Schneider, Rowan Stringer

JCI Insight· March 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists.
Samuel Hintermann, Christine Guntermann, Henri Mattes, David A Carcache, Juergen Wagner, Rowan Stringer

ChemMedChem· December 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of Platelet-Derived Growth Factor Receptor (PDGFR) Inhibitors for Duration of Action, as an Inhaled Therapy for Lung Remodeling in Pulmonary Arterial Hypertension.
Duncan E Shaw, Ferheen Baig, Ian Bruce, Sylvie Chamoin, Stephen P Collingwood, Rowan Stringer

J Med Chem· September 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.
Rowan A Stringer, Suzie Ferreira, Jonathan Rose, Sebastien Ronseaux

Drug Metab Dispos· August 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist.
Rowan A Stringer, Eckhard Weber, Andrew Culshaw, Jeff McKenna, Gareth Williams

Xenobiotica· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
1
1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.
Rowan A Stringer, Eckhard Weber, Bruno Tigani, Paul Lavan, Stephen Medhurst

Drug Metab Dispos· July 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists.
Lisa Rooney, Agnès Vidal, Anne-Marie D'Souza, Nick Devereux, Brian Masick, Rowan Stringer

J Med Chem· June 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.
Rowan A Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz

Drug Metab Dispos· May 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Clearance mechanism assignment and total clearance prediction in human based upon in silico models.
Franco Lombardo, R Scott Obach, Manthena V Varma, Rowan Stringer, Giuliano Berellini

J Med Chem· May 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.
David A Sandham, Nicola Arnold, Heinrich Aschauer, Kamlesh Bala, Lucy Barker, Rowan Stringer

Bioorg Med Chem· November 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis