Publications by authors named "Roy Pettipher"

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Prostaglandin D2 and leukotriene E4 synergize to stimulate diverse TH2 functions and TH2 cell/neutrophil crosstalk.
Luzheng Xue, Joannah Fergusson, Maryam Salimi, Isabel Panse, James E Ussher, Roy Pettipher

J Allergy Clin Immunol· May 2015

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Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459.
Dave Singh, Paul Cadden, Michael Hunter, Lisa Pearce Collins, Mike Perkins, Roy Pettipher

Eur Respir J· January 2013

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PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
Ralf Schröder, Luzheng Xue, Viktoria Konya, Lene Martini, Nora Kampitsch, Roy Pettipher

PLoS One· July 2012

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Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis.
Roy Pettipher, Mark Whittaker

J Med Chem· April 2012

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Pharmacologic profile of OC000459, a potent, selective, and orally active D prostanoid receptor 2 antagonist that inhibits mast cell-dependent activation of T helper 2 lymphocytes and eosinophils.
Roy Pettipher, Shân L Vinall, Luzheng Xue, Graham Speight, Elizabeth R Townsend

J Pharmacol Exp Ther· February 2012

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Leukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.
Luzheng Xue, Anna Barrow, Vicki M Fleming, Michael G Hunter, Graham Ogg, Roy Pettipher

J Immunol· January 2012

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Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway.
Luzheng Xue, Anna Barrow, Roy Pettipher

J Immunol· June 2009

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Antagonists of the prostaglandin D2 receptor CRTH2.
Roy Pettipher, Trevor T Hansel

Drug News Perspect· January 2009

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A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.
Shân L Vinall, Elizabeth R Townsend, Roy Pettipher

Immunology· August 2007

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Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases.
Roy Pettipher, Trevor T Hansel, Richard Armer

Nat Rev Drug Discov· April 2007

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Inhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).
Luzheng Xue, Shân L Gyles, Anna Barrow, Roy Pettipher

Biochem Pharmacol· March 2007

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A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
Shân L Gyles, Luzheng Xue, Elizabeth R Townsend, Frank Wettey, Roy Pettipher

Immunology· November 2006

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Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes.
Frank R Wettey, Luzheng Xue, Roy Pettipher

Cytokine· October 2006

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Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.
Luzheng Xue, Shân L Gyles, Frank R Wettey, Lucien Gazi, Elizabeth Townsend, Roy Pettipher

J Immunol· November 2005

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Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
Richard E Armer, Mark R Ashton, Edward A Boyd, Chris J Brennan, Frederick A Brookfield, Roy Pettipher

J Med Chem· October 2005

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Identification of G-protein-coupled receptors involved in inflammatory disease by genetic association studies.
Roy Pettipher, Jon Mangion, Michael G Hunter, Ian Mackay

Curr Opin Pharmacol· August 2005

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Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.
Lucien Gazi, Shân Gyles, Jennifer Rose, Sally Lees, Chris Allan, Roy Pettipher

Prostaglandins Other Lipid Mediat· January 2005

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The application of genetics to the discovery of better medicines.
Roy Pettipher, Lon R Cardon

Pharmacogenomics· March 2002

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