Publications by authors named "Ruben Agudo"

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Development of a luminescence-based method for measuring West Nile Virus MTase activity and its application to screen for antivirals.
Alejandra Álvarez-Mínguez, Natalia Del Río, Ana Belén-Blázquez, Elena Casanova, José-María Orduña, Rubén Agudo

Curr Res Microb Sci· October 2024

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Revealing antibiotic resistance's ancient roots: insights from pristine ecosystems.
Rubén Agudo, M Paloma Reche

Front Microbiol· October 2024

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Identification of West Nile virus RNA-dependent RNA polymerase non-nucleoside inhibitors by real-time high throughput fluorescence screening.
Marta García-Zarandieta, Ernesto Quesada, María I Martínez-Jiménez, Cristina V Newnes, Victor Fernández-Cabello, Rubén Agudo

Antiviral Res· April 2023

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Novel Nonnucleoside Inhibitors of Zika Virus Polymerase Identified through the Screening of an Open Library of Antikinetoplastid Compounds.
Yanira Sáez-Álvarez, Nereida Jiménez de Oya, Carmen Del Águila, Juan-Carlos Saiz, Armando Arias, Rubén Agudo

Antimicrob Agents Chemother· August 2021

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Development of a fluorescence-based method for the rapid determination of Zika virus polymerase activity and the screening of antiviral drugs.
Yanira Sáez-Álvarez, Armando Arias, Carmen Del Águila, Rubén Agudo

Sci Rep· April 2019

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Engineering human PrimPol into an efficient RNA-dependent-DNA primase/polymerase.
Rubén Agudo, Patricia A Calvo, María I Martínez-Jiménez, Luis Blanco

Nucleic Acids Res· September 2017

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Involvement of a joker mutation in a polymerase-independent lethal mutagenesis escape mechanism.
Rubén Agudo, Ignacio de la Higuera, Armando Arias, Ana Grande-Pérez, Esteban Domingo

Virology· July 2016

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Biocatalytic route to chiral acyloins: P450-catalyzed regio- and enantioselective α-hydroxylation of ketones.
Rubén Agudo, Gheorghe-Doru Roiban, Richard Lonsdale, Adriana Ilie, Manfred T Reetz

J Org Chem· January 2015

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Directed evolution of stereoselective enzymes based on genetic selection as opposed to screening systems.
Carlos G Acevedo-Rocha, Ruben Agudo, Manfred T Reetz

J Biotechnol· December 2014

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CH-activating oxidative hydroxylation of 1-tetralones and related compounds with high regio- and stereoselectivity.
Gheorghe-Doru Roiban, Rubén Agudo, Adriana Ilie, Richard Lonsdale, Manfred T Reetz

Chem Commun (Camb)· November 2014

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Cytochrome P450 catalyzed oxidative hydroxylation of achiral organic compounds with simultaneous creation of two chirality centers in a single C-H activation step.
Gheorghe-Doru Roiban, Rubén Agudo, Manfred T Reetz

Angew Chem Int Ed Engl· August 2014

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Designer cells for stereocomplementary de novo enzymatic cascade reactions based on laboratory evolution.
Rubén Agudo, Manfred T Reetz

Chem Commun (Camb)· December 2013

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Directed evolution by using iterative saturation mutagenesis based on multiresidue sites.
Loreto P Parra, Rubén Agudo, Manfred T Reetz

Chembiochem· November 2013

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Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.
Armando Arias, Ana Isabel de Ávila, Marta Sanz-Ramos, Rubén Agudo, Cristina Escarmís

J Gen Virol· April 2013

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Induced axial chirality in biocatalytic asymmetric ketone reduction.
Rubén Agudo, Gheorghe-Doru Roiban, Manfred T Reetz

J Am Chem Soc· February 2013

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Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.
Rubén Agudo, Gheorghe-Doru Roiban, Manfred T Reetz

Chembiochem· July 2012

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Influence of mutagenesis and viral load on the sustained low-level replication of an RNA virus.
Celia Perales, Rubén Agudo, Susanna C Manrubia, Esteban Domingo

J Mol Biol· March 2011

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A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
Rubén Agudo, Cristina Ferrer-Orta, Armando Arias, Ignacio de la Higuera, Celia Perales

PLoS Pathog· August 2010

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Structure of foot-and-mouth disease virus mutant polymerases with reduced sensitivity to ribavirin.
Cristina Ferrer-Orta, Macarena Sierra, Rubén Agudo, Ignacio de la Higuera, Armando Arias

J Virol· June 2010

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Structural insights into replication initiation and elongation processes by the FMDV RNA-dependent RNA polymerase.
Cristina Ferrer-Orta, Rubén Agudo, Esteban Domingo, Nuria Verdaguer

Curr Opin Struct Biol· December 2009

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Potential benefits of sequential inhibitor-mutagen treatments of RNA virus infections.
Celia Perales, Rubén Agudo, Hector Tejero, Susanna C Manrubia, Esteban Domingo

PLoS Pathog· November 2009

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Counteracting quasispecies adaptability: extinction of a ribavirin-resistant virus mutant by an alternative mutagenic treatment.
Celia Perales, Rubén Agudo, Esteban Domingo

PLoS One· August 2009

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5-fluorouracil in lethal mutagenesis of foot-and-mouth disease virus.
Rubén Agudo, Armando Arias, Esteban Domingo

Future Med Chem· June 2009

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Molecular characterization of a dual inhibitory and mutagenic activity of 5-fluorouridine triphosphate on viral RNA synthesis. Implications for lethal mutagenesis.
Rubén Agudo, Armando Arias, Nonia Pariente, Celia Perales, Cristina Escarmís

J Mol Biol· October 2008

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Topology of evolving, mutagenized viral populations: quasispecies expansion, compression, and operation of negative selection.
Samuel Ojosnegros, Rubén Agudo, Macarena Sierra, Carlos Briones, Saleta Sierra

BMC Evol Biol· July 2008

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