Publications by authors named "Ruben Boado"

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Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme.
Andreas Hahn, Yuji Sato, Toshiaki Ikeda, Hiroyuki Sonoda, Mathias Schmidt, Ruben J Boado

Mol Genet Metab Rep· December 2022

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IgG Fusion Proteins for Brain Delivery of Biologics via Blood-Brain Barrier Receptor-Mediated Transport.
Ruben J Boado

Pharmaceutics· July 2022

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A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease.
Rudy Chang, Abrar Al Maghribi, Victoria Vanderpoel, Vitaly Vasilevko, David H Cribbs, Ruben Boado

Mol Pharm· January 2020

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Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery.
Ruben J Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui, Huilan Lin, William M Pardridge

Sci Rep· December 2019

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Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice.
Jiahong Sun, Joshua Yang, Kathrine Whitman, Charlene Zhu, David H Cribbs, Ruben J Boado

Alzheimers Dement (N Y)· October 2019

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Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice.
Jiahong Sun, Ruben J Boado, William M Pardridge, Rachita K Sumbria

Mol Pharm· August 2019

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Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor.
William M Pardridge, Ruben J Boado, Daniel J Patrick, Eric Ka-Wai Hui, Jeff Zhiqiang Lu

Mol Pharm· November 2018

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Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease.
Rudy Chang, Abrar Al Maghribi, Victoria Vanderpoel, Vitaly Vasilevko, David H Cribbs, Ruben Boado

Mol Pharm· November 2018

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Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial.
Roberto Giugliani, Luciana Giugliani, Fabiano de Oliveira Poswar, Karina Carvalho Donis, Amauri Dalla Corte, Ruben J Boado

Orphanet J Rare Dis· July 2018

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Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I.
William M Pardridge, Ruben J Boado, Roberto Giugliani, Mathias Schmidt

BioDrugs· April 2018

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Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse-Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse.
Ruben J Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui, William M Pardridge

Mol Pharm· February 2018

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Blood-Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer's Disease.
Rudy Chang, Jillian Knox, Jae Chang, Aram Derbedrossian, Vitaly Vasilevko, Ruben J Boado

Mol Pharm· July 2017

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A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment.
Mitra Azadeh, Luying Pan, Yongchang Qiu, Ruben Boado

JIMD Rep· June 2017

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Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein.
Ruben J Boado, William M Pardridge

Mol Pharm· April 2017

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Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey.
Ruben J Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, William M Pardridge

Mol Pharm· September 2016

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Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts.
Ruben J Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui, Huilan Lin, William M Pardridge

Mol Pharm· April 2016

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Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys.
Ruben J Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, William M Pardridge

Biotechnol Bioeng· November 2014

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Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells.
Ruben J Boado, Jeff Zhiqiang Lu, Eric Ka-Wai Hui, William M Pardridge

Mol Pharm· August 2014

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Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey.
Ruben J Boado, Eric K-W Hui, Jeff Zhiqiang Lu, Rachita K Sumbria, William M Pardridge

Bioconjug Chem· October 2013

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Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide.
Rachita K Sumbria, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J Boado, William M Pardridge

Mol Pharm· September 2013

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Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor.
Ruben J Boado, Jeff Zhiqiang Lu, Eric K-W Hui, Rachita K Sumbria, William M Pardridge

Biotechnol Bioeng· May 2013

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Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice.
Rachita K Sumbria, Qing-Hui Zhou, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, Ruben J Boado

Mol Pharm· April 2013

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Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins.
Rachita K Sumbria, Ruben J Boado, William M Pardridge

Brain Res· April 2013

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Immunologic privilege in the central nervous system and the blood-brain barrier.
Leslie L Muldoon, Jorge I Alvarez, David J Begley, Ruben J Boado, Gregory J Del Zoppo

J Cereb Blood Flow Metab· January 2013

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IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys.
Ruben J Boado, Eric Ka-Wai Hui, Jeff Zhiqiang Lu, William M Pardridge

Bioconjug Chem· January 2013

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