Publications by authors named "Ruben Doste"

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Sex-specific human electromechanical multiscale in-silico models for virtual therapy evaluation.
Maxx Holmes, Zhinuo Jenny Wang, Ruben Doste, Julia Camps, Hector Martinez-Navarro

J Mol Cell Cardiol Plus· September 2025

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Harnessing 12-lead ECG and MRI data to personalise repolarisation profiles in cardiac digital twin models for enhanced virtual drug testing.
Julia Camps, Zhinuo Jenny Wang, Ruben Doste, Lucas Arantes Berg, Maxx Holmes

Med Image Anal· February 2025

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ECG analysis of ventricular fibrillation dynamics reflects ischaemic progression subject to variability in patient anatomy and electrode location.
Hector Martinez-Navarro, Ambre Bertrand, Ruben Doste, Hannah Smith, Jakub Tomek

Front Cardiovasc Med· November 2024

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In silico evaluation of cell therapy in acute versus chronic infarction: role of automaticity, heterogeneity and Purkinje in human.
Leto Luana Riebel, Zhinuo Jenny Wang, Hector Martinez-Navarro, Cristian Trovato, Julia Camps, Ruben Doste

Sci Rep· September 2024

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Mechanisms of ischaemia-induced arrhythmias in hypertrophic cardiomyopathy: a large-scale computational study.
James A Coleman, Ruben Doste, Zakariye Ashkir, Raffaele Coppini, Rafael Sachetto

Cardiovasc Res· July 2024

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Digital twinning of the human ventricular activation sequence to Clinical 12-lead ECGs and magnetic resonance imaging using realistic Purkinje networks for in silico clinical trials.
Julia Camps, Lucas Arantes Berg, Zhinuo Jenny Wang, Rafael Sebastian, Leto Luana Riebel, Ruben Doste

Med Image Anal· May 2024

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Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy.
James A Coleman, Ruben Doste, Matteo Beltrami, Alessia Argirò, Raffaele Coppini

Front Pharmacol· April 2024

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Electrophysiological mechanisms underlying T wave pseudonormalisation on stress ECGs in hypertrophic cardiomyopathy.
James A Coleman, Ruben Doste, Matteo Beltrami, Raffaele Coppini, Iacopo Olivotto

Comput Biol Med· February 2024

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Ventricular anatomical complexity and sex differences impact predictions from electrophysiological computational models.
Pablo Gonzalez-Martin, Federica Sacco, Constantine Butakoff, Ruben Doste, Carlos Bederian

PLoS One· February 2023

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Mechanism based therapies enable personalised treatment of hypertrophic cardiomyopathy.
Francesca Margara, Yiangos Psaras, Zhinuo Jenny Wang, Manuel Schmid, Ruben Doste

Sci Rep· December 2022

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Remodelling of potassium currents underlies arrhythmic action potential prolongation under beta-adrenergic stimulation in hypertrophic cardiomyopathy.
Ruben Doste, Raffaele Coppini, Alfonso Bueno-Orovio

J Mol Cell Cardiol· November 2022

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Training machine learning models with synthetic data improves the prediction of ventricular origin in outflow tract ventricular arrhythmias.
Ruben Doste, Miguel Lozano, Guillermo Jimenez-Perez, Lluis Mont, Antonio Berruezo

Front Physiol· August 2022

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Pharmacological Management of Hypertrophic Cardiomyopathy: From Bench to Bedside.
Chiara Palandri, Lorenzo Santini, Alessia Argirò, Francesca Margara, Ruben Doste

Drugs· June 2022

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Paradoxical prolongation of QT interval during exercise in patients with hypertrophic cardiomyopathy: cellular mechanisms and implications for diastolic function.
Raffaele Coppini, Matteo Beltrami, Ruben Doste, Alfonso Bueno-Orovio, Cecilia Ferrantini

Eur Heart J Open· May 2022

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In silico pace-mapping: prediction of left vs. right outflow tract origin in idiopathic ventricular arrhythmias with patient-specific electrophysiological simulations.
Ruben Doste, Rafael Sebastian, Juan Francisco Gomez, David Soto-Iglesias, Alejandro Alcaine

Europace· September 2020

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A rule-based method to model myocardial fiber orientation in cardiac biventricular geometries with outflow tracts.
Ruben Doste, David Soto-Iglesias, Gabriel Bernardino, Alejandro Alcaine, Rafael Sebastian

Int J Numer Method Biomed Eng· April 2019

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