Publications by authors named "Ruby L-C Hoo"

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Adipocyte-derived FABP4 promotes metabolism-associated steatotic liver-induced hepatocellular carcinoma by driving ITGB1-mediated β-catenin activation.
Carmen Oi Ning Leung, Shilpa Gurung, Katherine Po Sin Chung, Rainbow Wing Hei Leung, Martina Mang Leng Lei, Ruby Lai Chong Hoo

J Clin Invest· December 2025

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Prevalence and incidence of chronic kidney diseases in Hong Kong: a 12-year territory-wide retrospective cohort study.
Noel C Yue, Shun-Cheong Ho, Jonathan K L Mak, Franco W T Cheng, Edward Y W Tam, Ruby L C Hoo

Lancet Reg Health West Pac· November 2025

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Adipocyte-derived shed Syndecan-4 suppresses lipolysis contributing to impaired adipose tissue browning and adaptive thermogenesis.
Jiuyu Zong, Xiaoping Wu, Xiaowen Huang, Lufengzi Yuan, Kai Yuan, Ruby Lai Chong Hoo

Mol Metab· June 2025

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Plasma Proteome-Wide Mendelian Randomization Analysis Reveals Biomarkers and Therapeutic Targets for Different Stages of COVID-19.
Suhas Krishnamoorthy, Ruby Lai Chong Hoo, Ching Lung Cheung

Transbound Emerg Dis· April 2025

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Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis.
Xiaoping Wu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lufengzi Yuan, Ruby L C Hoo

Adv Sci (Weinh)· April 2025

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Neutrophil serine proteases NE and PR3 controlled by the miR-223/STAT3 axis potentiate MASH and liver fibrosis.
Pengfei Zhang, Dongyang Liu, Lihong Wu, Xiaoqin Wu, Kaixuan Yan, Ruby Lai Chong Hoo

Hepatology· March 2025

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Compromised endothelial Wnt/β-catenin signaling mediates the blood-brain barrier disruption and leads to neuroinflammation in endotoxemia.
Xiaowen Huang, Pengju Wei, Cheng Fang, Min Yu, Shilun Yang, Ruby Lai Chong Hoo

J Neuroinflammation· October 2024

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Development of a therapeutic monoclonal antibody against circulating adipocyte fatty acid binding protein to treat ischaemic stroke.
Boya Liao, Shilun Yang, Leiluo Geng, Jiuyu Zong, Zixuan Zhang, Ruby Lai Chong Hoo

Br J Pharmacol· April 2024

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Levofloxacin alleviates blood-brain barrier disruption following cerebral ischemia and reperfusion via directly inhibiting A-FABP.
Shilun Yang, Dingkang Xu, Dianhui Zhang, Xiaowen Huang, Simeng Li, Ruby Lai Chong Hoo

Eur J Pharmacol· January 2024

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An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activity.
Yabin Ji, Qiang Gao, Yinzhong Ma, Fang Wang, Xixi Tan, Ruby L C Hoo

Pharmacol Res· April 2023

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Fibroblastic reticular cells in lymph node potentiate white adipose tissue beiging through neuro-immune crosstalk in male mice.
Lai Yee Cheong, Baile Wang, Qin Wang, Leigang Jin, Kelvin H M Kwok, Ruby L C Hoo

Nat Commun· March 2023

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Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis.
Han Qiu, Erfei Song, Yue Hu, Tengfei Li, Kam Ching Ku, Ruby L C Hoo

Cell Mol Gastroenterol Hepatol· October 2022

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The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages.
Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo

Nat Commun· November 2021

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Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells.
Xiaoping Wu, Lingling Shu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Ruby L C Hoo

Adv Sci (Weinh)· June 2021

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Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier.
Boya Liao, Leiluo Geng, Fang Zhang, Lingling Shu, Ling Wei, Ruby L C Hoo

Eur Heart J· September 2020

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CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis-Driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear Relocalization and Activation.
Tin-Lok Wong, Kai-Yu Ng, Kel Vin Tan, Lok-Hei Chan, Lei Zhou, Ruby L C Hoo

Hepatology· April 2020

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Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation.
Yong Pan, Xiaoyan Hui, Ruby Lai Chong Hoo, Dewei Ye, Cyrus Yuk Cheung Chan

J Clin Invest· February 2019

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Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy.
Ruby L C Hoo, Lingling Shu, Kenneth K Y Cheng, Xiaoping Wu, Boya Liao

Sci Rep· January 2017

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A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.
Lingling Shu, Ruby L C Hoo, Xiaoping Wu, Yong Pan, Ida P C Lee

Nat Commun· January 2017

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Adipose-specific inactivation of JNK alleviates atherosclerosis in apoE-deficient mice.
Kelvin H M Kwok, Kenneth K Y Cheng, Ruby L C Hoo, Dewei Ye, Aimin Xu

Clin Sci (Lond)· November 2016

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Erratum. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4A Signaling Pathway. Diabetes 2010;59:2949-2959.
Junlei Chang, Yiming Li, Yu Huang, Karen S L Lam, Ruby L C Hoo

Diabetes· October 2016

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The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells.
Xiaomu Li, Kenneth K Y Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Ruby L C Hoo

Nat Commun· June 2016

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Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction.
Mi Zhou, Yuqian Bao, Haobo Li, Yong Pan, Lingling Shu, Ruby L-C Hoo

Clin Sci (Lond)· October 2015

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Metabolomic profiling in liver of adiponectin-knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action.
Ying Liu, Sanjana Sen, Sivaporn Wannaiampikul, Rengasamy Palanivel, Ruby L C Hoo

Biochem J· July 2015

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Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin.
Suk Yu Yau, Ang Li, Ruby L C Hoo, Yick Pang Ching, Brian R Christie

Proc Natl Acad Sci U S A· November 2014

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