Publications by authors named "Rudolf Andrys"

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Transforming ureas into carbamates: From allosteric p38α MAPK ligands to dual BChE/p38α MAPK inhibitors.
Svit Ferjančič Benetik, Anže Meden, Damijan Knez, Peter Mastnak-Sokolov, Urban Košak, Rudolf Andrys

Bioorg Chem· October 2025

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Chitosan-based film-forming systems with cannabidiol: a novel topical strategy for antimicrobial therapy.
Andrea Veris, Jan Loskot, Rudolf Andrys, Klara Konecna, Ondrej Jandourek

Int J Pharm· September 2025

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Degradation behavior and environmental impacts of a hemp-containing "eco-friendly" compostable plastic in natural environments.
Jan Loskot, Klára Katonová, Daniel Jezbera, Rudolf Andrýs, Roman Svoboda

Waste Manag· September 2025

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Immobilized animal liver microsomes: A versatile tool for efficient ester hydrolysis in chemo-enzymatic synthesis.
Charline Monnier, Rudolf Andrys, Irene Castellino, Veronika Mickova, Annamaria Haleckova

Methods· August 2025

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N-4-aminobenzyl-N'-(2-(2-phenylpyrrolidin)-2-oxoethyl)urea-based inhibitors of cyclophilin D - Preparation of distinct stereoisomers and comparative analysis of their in vitro bioactivity.
Annamaria Haleckova, Katarina Jurkova, Jan Hurdalek, Katarina Chalupova, Veronika Syrova, Rudolf Andrys

Bioorg Chem· August 2025

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Targeting Neuroinflammation and Cognitive Decline: First-in-Class Dual Butyrylcholinesterase and p38α Mitogen-Activated Protein Kinase Inhibitors.
Svit Ferjančič Benetik, Matic Proj, Damijan Knez, Urban Košak, Anže Meden, Rudolf Andrys

J Med Chem· August 2025

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New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer's disease.
Aneta Houfková, Monika Schmidt, Ondřej Benek, Ivo Fabrik, Rudolf Andrýs

Alzheimers Res Ther· July 2025

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Erratum to "Frentizole derivatives with mTOR inhibiting and senomorphic properties" [Biomed. Pharmacother. 167 (2023) 115600].
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys

Biomed Pharmacother· March 2025

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Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes.
Zuzana Kohoutova, Eliska Prchalova, Rudolf Andrys, Karolina Knittelova, Marketa Formanova

Bioorg Chem· December 2024

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Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases.
Karolina Knittelova, Eliska Prchalova, Adela Fuchsova, Rudolf Andrys, Zuzana Kohoutova

ACS Med Chem Lett· December 2024

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Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents.
Eliska Prchalova, Rudolf Andrys, Jaroslav Pejchal, Zuzana Kohoutova, Karolina Knittelova

Arch Toxicol· September 2024

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Discovery of a 6-Aminobenzo[]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities.
Patrik Oleksak, David Rysanek, Marketa Vancurova, Pavla Vasicova, Alexandra Urbancokova, Rudolf Andrys

ACS Pharmacol Transl Sci· September 2024

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Towards cost-effective drug discovery: Reusable immobilized enzymes for neurological disease research.
Rudolf Andrys, Charline Monnier, Evica Antonijević Miljaković, Veronika Mickova, Kamil Musilek

Talanta· August 2024

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Formulation study of PLGA in situ films for topical delivery of salicylates.
Eva Snejdrova, Jan Loskot, Andrea Veris, Petr Kastner, Rudolf Andrys

Eur J Pharm Biopharm· June 2024

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Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity.
Michaela Hanzlova, Marketa Sedlacek Miskerikova, Aneta Rotterova, Katarina Chalupova, Katarina Jurkova, Rudolf Andrys

ACS Med Chem Lett· December 2023

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BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS.
Eliska Prchalova, Martina Sukupova, David Malinak, Rudolf Andrys, Ladislav Sivak

Biomed Pharmacother· November 2023

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Frentizole derivatives with mTOR inhibiting and senomorphic properties.
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys

Biomed Pharmacother· November 2023

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Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation.
Ondrej Benek, Michaela Vaskova, Marketa Miskerikova, Monika Schmidt, Rudolf Andrys

Eur J Med Chem· October 2023

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Structure-Guided Design of -Methylpropargylamino-Quinazoline Derivatives as Multipotent Agents for the Treatment of Alzheimer's Disease.
Barbora Svobodova, Lenka Pulkrabkova, Dawid Panek, Anna Misiachna, Marharyta Kolcheva, Rudolf Andrys

Int J Mol Sci· May 2023

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STAT3 inhibitor Stattic and its analogues inhibit STAT3 phosphorylation and modulate cytokine secretion in senescent tumour cells.
Romana Mikyskova, Olena Sapega, Miroslav Psotka, Ondrej Novotny, Zdeněk Hodny, Rudolf Andrys

Mol Med Rep· April 2023

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Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols.
Oleksandr Kozlov, Eliška Horáková, Sára Rademacherová, Dávid Maliňák, Rudolf Andrýs

Anal Chem· March 2023

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Privileged multi-target directed propargyl-tacrines combining cholinesterase and monoamine oxidase inhibition activities.
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova

J Enzyme Inhib Med Chem· December 2022

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Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics.
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Marek Bajda, Rudolf Andrys

Front Aging Neurosci· December 2022

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Allogeneic Bone Impregnated with Biodegradable Depot Delivery Systems for the Local Treatment of Joint Replacement Infections: An In Vitro Study.
Libor Prokes, Eva Snejdrova, Tomas Soukup, Jana Malakova, Vladislav Frolov, Rudolf Andrys

Molecules· October 2022

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Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870.
Jana Zdarova Karasova, Jiri Kassa, Vendula Hepnarova, Jaroslav Pejchal, Lucie Junova, Rudolf Andrys

Food Chem Toxicol· September 2022

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