Publications by authors named "Ruizhuo Lin"

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Dihydroorotate dehydrogenase inhibition activates STING pathway and pyroptosis to enhance NK cell-dependent tumor immunotherapy.
Yongrui Hai, Ruizhuo Lin, Weike Liao, Shuo Fu, Renming Fan

Mol Biomed· October 2025

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Innovative PDK1-Degrading PROTACs Transform Cancer Aerobic Glycolysis and Induce Immunogenic Cell Death in Breast Cancer.
Aohua Deng, Renming Fan, Jiakui Gou, Ruoxi Sang, Ruizhuo Lin, Jialin Sun

Exploration (Beijing)· August 2025

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A platinum(IV)-artesunate complex triggers ferroptosis by boosting cytoplasmic and mitochondrial lipid peroxidation to enhance tumor immunotherapy.
Renming Fan, Aohua Deng, Ruizhuo Lin, Shuo Zhang, Caiyan Cheng

MedComm (2020)· June 2024

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A novel mitochondria-targeting DHODH inhibitor induces robust ferroptosis and alleviates immune suppression.
Yongrui Hai, Renming Fan, Ting Zhao, Ruizhuo Lin, Junyan Zhuang

Pharmacol Res· April 2024

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Novel Pt(IV) complex OAP2 induces STING activation and pyroptosis mitochondrial membrane remodeling for synergistic chemo-immunotherapy.
Renming Fan, Ruizhuo Lin, Shuo Zhang, Aohua Deng, Yongrui Hai

Acta Pharm Sin B· April 2024

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Degradation of Hexokinase 2 Blocks Glycolysis and Induces GSDME-Dependent Pyroptosis to Amplify Immunogenic Cell Death for Breast Cancer Therapy.
Ruoxi Sang, Renming Fan, Aohua Deng, Jiakui Gou, Ruizhuo Lin

J Med Chem· July 2023

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: A Novel Potent Platinum(IV) Prodrug Enhances Chemo-Immunotherapy by Facilitating PD-L1 Degradation in the Cytoplasm and Cytomembrane.
Renming Fan, Aohua Deng, Bing Qi, Shuo Zhang, Ruoxi Sang, Ruizhuo Lin

J Med Chem· January 2023

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