Publications by authors named "Ruth Saecker"

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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.
Ruth M Saecker, Andreas U Mueller, Brandon Malone, James Chen, William C Budell

Nat Struct Mol Biol· November 2024

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Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy.
Ruth M Saecker, Andreas U Mueller, Brandon Malone, James Chen, William C Budell

bioRxiv· March 2024

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Structural origins of RNA polymerase open promoter complex stability.
Ruth M Saecker, James Chen, Courtney E Chiu, Brandon Malone, Johanna Sotiris

Proc Natl Acad Sci U S A· October 2021

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Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.
Paul Dominic B Olinares, Jin Young Kang, Eliza Llewellyn, Courtney Chiu, James Chen, Ruth M Saecker

Structure· February 2021

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Time-resolved cryo-EM using Spotiton.
Venkata P Dandey, William C Budell, Hui Wei, Daija Bobe, Kashyap Maruthi, Ruth M Saecker

Nat Methods· September 2020

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Transcription initiation in mycobacteria: a biophysical perspective.
Hande Boyaci, Ruth M Saecker, Elizabeth A Campbell

Transcription· April 2020

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Stepwise Promoter Melting by Bacterial RNA Polymerase.
James Chen, Courtney Chiu, Saumya Gopalkrishnan, Albert Y Chen, Paul Dominic B Olinares, Ruth M Saecker

Mol Cell· April 2020

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Structure and function of the mycobacterial transcription initiation complex with the essential regulator RbpA.
Elizabeth A Hubin, Allison Fay, Catherine Xu, James M Bean, Ruth M Saecker

Elife· January 2017

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Fluorescence Resonance Energy Transfer Characterization of DNA Wrapping in Closed and Open Escherichia coli RNA Polymerase-λP(R) Promoter Complexes.
Raashi Sreenivasan, Sara Heitkamp, Munish Chhabra, Ruth Saecker, Emily Lingeman

Biochemistry· April 2016

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Mechanism of bacterial transcription initiation: RNA polymerase - promoter binding, isomerization to initiation-competent open complexes, and initiation of RNA synthesis.
Ruth M Saecker, M Thomas Record, Pieter L Dehaseth

J Mol Biol· October 2011

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Nonspecific DNA binding and bending by HUαβ: interfaces of the three binding modes characterized by salt-dependent thermodynamics.
Junseock Koh, Irina Shkel, Ruth M Saecker, M Thomas Record

J Mol Biol· July 2011

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One-step DNA melting in the RNA polymerase cleft opens the initiation bubble to form an unstable open complex.
Theodore J Gries, Wayne S Kontur, Michael W Capp, Ruth M Saecker, M Thomas Record

Proc Natl Acad Sci U S A· June 2010

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Probing DNA binding, DNA opening, and assembly of a downstream clamp/jaw in Escherichia coli RNA polymerase-lambdaP(R) promoter complexes using salt and the physiological anion glutamate.
Wayne S Kontur, Michael W Capp, Theodore J Gries, Ruth M Saecker, M Thomas Record

Biochemistry· May 2010

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Interactions of the osmolyte glycine betaine with molecular surfaces in water: thermodynamics, structural interpretation, and prediction of m-values.
Michael W Capp, Laurel M Pegram, Ruth M Saecker, Megan Kratz, Demian Riccardi

Biochemistry· November 2009

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Evidence for a tyrosine-adenine stacking interaction and for a short-lived open intermediate subsequent to initial binding of Escherichia coli RNA polymerase to promoter DNA.
Lisa A Schroeder, Theodore J Gries, Ruth M Saecker, M Thomas Record, Michael E Harris

J Mol Biol· January 2009

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DNA binding mode transitions of Escherichia coli HU(alphabeta): evidence for formation of a bent DNA--protein complex on intact, linear duplex DNA.
Junseock Koh, Ruth M Saecker, M Thomas Record

J Mol Biol· November 2008

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Formation of a wrapped DNA-protein interface: experimental characterization and analysis of the large contributions of ions and water to the thermodynamics of binding IHF to H' DNA.
Kirk A Vander Meulen, Ruth M Saecker, M Thomas Record

J Mol Biol· March 2008

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Late steps in the formation of E. coli RNA polymerase-lambda P R promoter open complexes: characterization of conformational changes by rapid [perturbant] upshift experiments.
Wayne S Kontur, Ruth M Saecker, Michael W Capp, M Thomas Record

J Mol Biol· February 2008

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Real-time footprinting of DNA in the first kinetically significant intermediate in open complex formation by Escherichia coli RNA polymerase.
Caroline A Davis, Craig A Bingman, Robert Landick, M Thomas Record, Ruth M Saecker

Proc Natl Acad Sci U S A· May 2007

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Synthesis-mediated release of a small RNA inhibitor of RNA polymerase.
Karen M Wassarman, Ruth M Saecker

Science· December 2006

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Do sigma factors need help with a meltdown?
Ruth M Saecker, Caroline A Davis, M T Record

Cell· October 2006

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Solute probes of conformational changes in open complex (RPo) formation by Escherichia coli RNA polymerase at the lambdaPR promoter: evidence for unmasking of the active site in the isomerization step and for large-scale coupled folding in the subsequent conversion to RPo.
Wayne S Kontur, Ruth M Saecker, Caroline A Davis, Michael W Capp, M Thomas Record

Biochemistry· February 2006

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Use of urea and glycine betaine to quantify coupled folding and probe the burial of DNA phosphates in lac repressor-lac operator binding.
Jiang Hong, Mike W Capp, Ruth M Saecker, M Thomas Record

Biochemistry· December 2005

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The effects of upstream DNA on open complex formation by Escherichia coli RNA polymerase.
Caroline A Davis, Michael W Capp, M Thomas Record, Ruth M Saecker

Proc Natl Acad Sci U S A· January 2005

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Preferential interactions of glycine betaine and of urea with DNA: implications for DNA hydration and for effects of these solutes on DNA stability.
Jiang Hong, Michael W Capp, Charles F Anderson, Ruth M Saecker, Daniel J Felitsky

Biochemistry· November 2004

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