Publications by authors named "Ruud Ubink"

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Preclinical Profile of BYON3521 Predicts an Effective and Safe MET Antibody-Drug Conjugate.
Patrick G Groothuis, Daniëlle C H Jacobs, Inge A T Hermens, Désirée Damming, Kim Berentsen, Ruud Ubink

Mol Cancer Ther· June 2023

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Discovery of SYD5115, a novel orally active small molecule TSH-R antagonist.
Willem F J Karstens, Wiro M B P Menge, Gijs Martens, Sanne J N Op Het Veld, Jacobus Th H van Eupen, Ruud Ubink

Bioorg Med Chem· April 2023

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BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells.
Mary J van Helden, Seline A Zwarthoff, Roel J Arends, Inge M J Reinieren-Beeren, Marc C B C Paradé, Ruud Ubink

J Immunother Cancer· April 2023

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A Platform for the Generation of Site-Specific Antibody-Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines.
Ruud G E Coumans, Gerry J A Ariaans, Henri J Spijker, Pascal Renart Verkerk, Patrick H Beusker, Ruud Ubink

Bioconjug Chem· September 2020

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Unraveling the Interaction between Carboxylesterase 1c and the Antibody-Drug Conjugate SYD985: Improved Translational PK/PD by Using Ces1c Knockout Mice.
Ruud Ubink, Eef H C Dirksen, Myrthe Rouwette, Ebo S Bos, Ingrid Janssen

Mol Cancer Ther· November 2018

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A comparison of anti-HER2 IgA and IgG1 in vivo efficacy is facilitated by high N-glycan sialylation of the IgA.
Gerard Ja Rouwendal, Miranda M van der Lee, Saskia Meyer, Karli R Reiding, Jan Schouten, Ruud Ubink

MAbs· September 2016

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Improved in vivo anti-tumor effects of IgA-Her2 antibodies through half-life extension and serum exposure enhancement by FcRn targeting.
Saskia Meyer, Maaike Nederend, J H Marco Jansen, Karli R Reiding, Shamir R Jacobino, Ruud Ubink

MAbs· September 2016

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Simultaneous Targeting of FcγRs and FcαRI Enhances Tumor Cell Killing.
Arianne M Brandsma, Toine Ten Broeke, Maaike Nederend, Laura A P M Meulenbroek, Geert van Tetering, Ruud Ubink

Cancer Immunol Res· December 2015

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Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody-Drug Conjugate SYD985.
Ronald C Elgersma, Ruud G E Coumans, Tijl Huijbregts, Wiro M P B Menge, John A F Joosten, Ruud Ubink

Mol Pharm· June 2015

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The Preclinical Profile of the Duocarmycin-Based HER2-Targeting ADC SYD985 Predicts for Clinical Benefit in Low HER2-Expressing Breast Cancers.
Miranda M C van der Lee, Patrick G Groothuis, Ruud Ubink, Monique A J van der Vleuten, Tanja A van Achterberg

Mol Cancer Ther· March 2015

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Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform.
Wim Dokter, Ruud Ubink, Miranda van der Lee, Monique van der Vleuten, Tanja van Achterberg

Mol Cancer Ther· November 2014

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NPY and its involvement in axon guidance, neurogenesis, and feeding.
Tomas Hökfelt, Davor Stanic, Staci D Sanford, Jesse C Gatlin, Ida Nilsson, Ruud Ubink

Nutrition· September 2008

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'Neuro'-peptides in glia: focus on NPY and galanin.
Ruud Ubink, Laura Calza, Tomas Hökfelt

Trends Neurosci· November 2003

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