Publications by authors named "Ryan Lithgo"

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Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors.
Xiaomin Ni, R Blake Richardson, Andre Schutzer Godoy, Matteo P Ferla, Caroline Kikawa, Ryan M Lithgo

Nat Commun· October 2025

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High-throughput crystallographic fragment screening of Zika virus NS3 Helicase.
Andre Schutzer Godoy, Charline Giroud, Nathalya C M R Mesquita, Gabriela Dias Noske, Victor Oliveira Gawriljuk, Ryan M Lithgo

bioRxiv· September 2025

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Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
Xiaomin Ni, R Blake Richardson, Andre Schutzer Godoy, Matteo P Ferla, Caroline Kikawa, Ryan M Lithgo

bioRxiv· February 2025

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Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors.
Frank von Delft, Xiaomin Ni, R Richardson, Andre Godoy, Matteo Ferla, Ryan Lithgo

Res Sq· February 2025

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Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.
Jasmin C Aschenbrenner, Andre Schutzer de Godoy, Michael Fairhead, Charles W E Tomlinson, Max Winokan, Ryan M Lithgo

bioRxiv· August 2024

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Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
Jessica F Calver, Nimesh R Parmar, Gemma Harris, Ryan M Lithgo, Panayiota Stylianou

J Biol Chem· June 2024

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Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals.
Ryan M Lithgo, Charles W E Tomlinson, Michael Fairhead, Max Winokan, Warren Thompson

bioRxiv· April 2024

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The adaptability of the ion-binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF.
Ryan M Lithgo, Marko Hanževački, Gemma Harris, Jos J A G Kamps, Ellie Holden

J Biol Chem· November 2023

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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Melissa L Boby, Daren Fearon, Matteo Ferla, Mihajlo Filep, Lizbé Koekemoer, Ryan M Lithgo

Science· November 2023

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Flavour compounds affect protein structure: The effect of methyl anthranilate on bovine serum albumin conformation.
Vlad Dinu, Pallab Kumar Borah, Molly Muleya, David J Scott, Ryan Lithgo

Food Chem· September 2022

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Changes in Membrane Protein Structural Biology.
James Birch, Harish Cheruvara, Nadisha Gamage, Peter J Harrison, Ryan Lithgo

Biology (Basel)· November 2020

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The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins.
Vlad Dinu, Yudong Lu, Nicola Weston, Ryan Lithgo, Hayley Coupe

Sci Rep· January 2020

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Characterisation of insulin analogues therapeutically available to patients.
Gary G Adams, Andrew Meal, Paul S Morgan, Qushmua E Alzahrani, Hanne Zobel, Ryan Lithgo

PLoS One· July 2018

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Full hydrodynamic reversibility of the weak dimerization of vancomycin and elucidation of its interaction with VanS monomers at clinical concentration.
Mary K Phillips-Jones, Ryan Lithgo, Vlad Dinu, Richard B Gillis, John E Harding

Sci Rep· October 2017

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