Publications by authors named "Ryan Paxman"

Claim this Profile
P
Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity.
Gabriel M Kline, Lisa Boinon, Adrian Guerrero, Sergei Kutseikin, Gabrielle Cruz, Ryan J Paxman

bioRxiv· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Divergent Proteome Reactivity Influences Arm-Selective Activation of the Unfolded Protein Response by Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Leonard Yoon

ACS Chem Biol· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.
Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Julia M Grandjean

bioRxiv· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma.
Luke T Nelson, Ryan J Paxman, Jin Xu, Bill Webb, Evan T Powers

Amyloid· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion.
Bibiana Rius, Jaleh S Mesgarzadeh, Isabelle C Romine, Ryan J Paxman, Jeffery W Kelly

Blood Adv· February 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming.
Julia M D Grandjean, Aparajita Madhavan, Lauren Cech, Bryan O Seguinot, Ryan J Paxman

Nat Chem Biol· October 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
Erik A Blackwood, Khalid Azizi, Donna J Thuerauf, Ryan J Paxman, Lars Plate

Nat Commun· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins.
Ryan Paxman, Lars Plate, Erik A Blackwood, Chris Glembotski, Evan T Powers

Elife· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The unfolded protein response regulator ATF6 promotes mesodermal differentiation.
Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Lars Plate

Sci Signal· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modulating protein quality control.
Lars Plate, Ryan J Paxman, R Luke Wiseman, Jeffery W Kelly

Elife· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation.
Lars Plate, Christina B Cooley, John J Chen, Ryan J Paxman, Ciara M Gallagher

Elife· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability.
Paul B Lawrence, Yulian Gavrilov, Sam S Matthews, Minnie I Langlois, Dalit Shental-Bechor, Ryan Paxman

J Am Chem Soc· December 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Two structural scenarios for protein stabilization by PEG.
Shu-Han Chao, Sam S Matthews, Ryan Paxman, Aleksei Aksimentiev, Martin Gruebele

J Phys Chem B· July 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis