Publications by authors named "Ryan Yoshimura"

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Plants vs. GPCRs: A workflow for ligand discovery from an extract library illustrated by dopamine receptors.
Travis Dabbous, Vivian DoanVo, Allyssa Ha, Ryan F Yoshimura, Geoffrey W Abbott

Biochem Pharmacol· January 2026

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A conifer metabolite corrects episodic ataxia type 1 by voltage sensor-mediated ligand activation of Kv1.1.
Rían W Manville, Lorenzo Foglia, Ryan F Yoshimura, Derk J Hogenkamp, Amy Nguyen

Proc Natl Acad Sci U S A· January 2025

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Polymodal K channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.
Rían W Manville, Ryan F Yoshimura, Andriy V Yeromin, Derk Hogenkamp, Jennifer van der Horst

Commun Biol· August 2024

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Behavioral and neuro-functional consequences of eliminating the KCNQ3 GABA binding site in mice.
Kiki J Chen, Ryan Yoshimura, Clarissa Adriana Edmundo, Tri Minh Truong, Olivier Civelli

Front Mol Neurosci· May 2023

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Alzheimer's disease is associated with disruption in thiamin transport physiology: A potential role for neuroinflammation.
Kalidas Ramamoorthy, Ryan Yoshimura, Saleh Al-Juburi, Kasin Y Anandam, Rubina Kapadia

Neurobiol Dis· September 2022

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KCNQ and KCNE Isoform-Dependent Pharmacology Rationalizes Native American Dual Use of Specific Plants as Both Analgesics and Gastrointestinal Therapeutics.
Geoffrey W Abbott, Kaitlyn E Redford, Ryan F Yoshimura, Rían W Manville, Luiz Moreira

Front Physiol· November 2021

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Metabolomic and transcriptomic signatures of prenatal excessive methionine support nature rather than nurture in schizophrenia pathogenesis.
Siwei Chen, Wedad Alhassen, Ryan Yoshimura, Angele De Silva, Geoffrey W Abbott

Commun Biol· July 2020

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Melanin Concentrating Hormone Signaling Deficits in Schizophrenia: Association With Memory and Social Impairments and Abnormal Sensorimotor Gating.
Marquis P Vawter, Anton Schulmann, Lamees Alhassen, Wedad Alhassen, Abdul Rezzak Hamzeh, Ryan Yoshimura

Int J Neuropsychopharmacol· March 2020

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Role of β-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis.
Doodipala Samba Reddy, Ryan F Yoshimura, Gunasekaran Ramanathan, Chase Carver, Timothy B Johnstone

Epilepsy Behav· May 2018

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Allosteric modulation of nicotinic and GABA receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model.
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Narielle L Ayala, Timothy Johnstone

Neuropharmacology· November 2017

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First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288.
Kelvin W Gee, Ann Olincy, Richard Kanner, Lynn Johnson, Derk Hogenkamp, Ryan Yoshimura

J Psychopharmacol· April 2017

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Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid.
Derk J Hogenkamp, Minhtam B Tran, Ryan F Yoshimura, Timothy B Johnstone, Richard Kanner

Psychopharmacology (Berl)· September 2014

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Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator.
Ryan F Yoshimura, Minhtam B Tran, Derk J Hogenkamp, Timothy B Johnstone, Jennifer Y Xie

J Psychopharmacol· May 2014

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Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors.
Derk J Hogenkamp, Thomas A Ford-Hutchinson, Wen-Yen Li, Edward R Whittemore, Ryan F Yoshimura

J Med Chem· November 2013

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Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition.
Timothy B Johnstone, Zhenglin Gu, Ryan F Yoshimura, Anne-Sophie Villegier, Derk J Hogenkamp

J Pharmacol Exp Ther· March 2011

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Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia.
Kelvin W Gee, Minhtam B Tran, Derk J Hogenkamp, Timothy B Johnstone, Rudy E Bagnera, Ryan F Yoshimura

J Pharmacol Exp Ther· March 2010

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Negative allosteric modulation of nicotinic acetylcholine receptors blocks nicotine self-administration in rats.
Ryan F Yoshimura, Derk J Hogenkamp, Wen Y Li, Minhtam B Tran, James D Belluzzi

J Pharmacol Exp Ther· December 2007

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Reversible lipidization for the oral delivery of leu-enkephalin.
Jeffrey Wang, Derk J Hogenkamp, Minhtam Tran, Wen-Yen Li, Ryan F Yoshimura

J Drug Target· April 2006

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Modifying quinolone antibiotics yields new anxiolytics.
Timothy B C Johnstone, Derk J Hogenkamp, Leanne Coyne, Jiping Su, Robert F Halliwell, Ryan F Yoshimura

Nat Med· January 2004

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