Publications by authors named "SA Freeman"

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Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?
Spencer A Freeman, Sergio Grinstein

J Cell Biol· January 2026

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Prevalence of hypogammaglobulinemia after non-anti-CD20 therapies and impact of switching to rituximab/ocrelizumab in multiple sclerosis.
Marine Perriguey, Camille Rigollet, Sean A Freeman, Lisa Graille-Avy, Jean-Christophe Lafontaine

Neurotherapeutics· October 2025

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Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and bacterial extracellular vesicles.
Ava A Kavianpour, Sina Ghasempour, Kirsten J Meyer, Trieu Le, Ruiqi Cai, Spencer A Freeman

Curr Biol· September 2025

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The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments.
Guillermo de Paz Linares, Jan Mossemann, Blayne Sayed, Spencer A Freeman

Mol Biol Cell· July 2025

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Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2.
Jing Ze Wu, Joshua G Pemberton, Shin Morioka, Junko Sasaki, Priya Bablani, Spencer A Freeman

J Cell Biol· June 2025

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Unraveling the pathophysiology of narcolepsy type 1 through hypothesis-driven and hypothesis-generating approaches.
Sean A Freeman, Ikram Ayoub, Yves Dauvilliers, Roland S Liblau

Semin Immunol· June 2025

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Extended-interval dosing of rituximab/ocrelizumab is associated with a reduced decrease in IgG levels in multiple sclerosis.
Camille Rigollet, Sean A Freeman, Marine Perriguey, Jan-Patrick Stellmann, Lisa Graille-Avy

Neurotherapeutics· April 2025

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The spectrum of lysosomal stress and damage responses: from mechanosensing to inflammation.
Ori Scott, Ekambir Saran, Spencer A Freeman

EMBO Rep· March 2025

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The neurorepellent SLIT2 inhibits LPS-induced proinflammatory signaling in macrophages.
Marko Skrtic, Bushra Yusuf, Sajedabanu Patel, Emily C Reddy, Kenneth K Y Ting, Spencer A Freeman

J Immunol· January 2025

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Anti-CD20 monoclonal antibodies in multiple sclerosis: Rethinking the current treatment strategy.
S A Freeman, H Zéphir

Rev Neurol (Paris)· December 2024

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Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.
Sina Ghasempour, Neil Warner, Rei Guan, Marco M Rodari, Danton Ivanochko, Spencer A Freeman

J Exp Med· December 2024

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Podosome Nucleation Is Facilitated by Multivalent Interactions between Syk and ITAM-containing Membrane Complexes.
Sina Ghasempour, Aleixo M Muise, Spencer A Freeman

J Immunol· October 2024

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Interleukin-1-mediated hyperinflammation in XIAP deficiency is associated with defective autophagy.
Dilan Dissanayake, Ashkan Firouzabady, Mohammad Massumi, Guillermo A de Paz Linares, Christian Marshall, Spencer A Freeman

Blood· September 2024

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Acidification of α-granules in megakaryocytes by vacuolar-type adenosine triphosphatase is essential for organelle biogenesis.
Chien-Yi Lu, Jing Ze Wu, Helen H Y Yao, Richard J Y Liu, Ling Li, Spencer A Freeman

J Thromb Haemost· August 2024

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Pressure sensing of lysosomes enables control of TFEB responses in macrophages.
Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Spencer A Freeman

Nat Cell Biol· August 2024

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Infection, vaccination and narcolepsy type 1: Evidence and potential molecular mechanisms.
Ikram Ayoub, Sean A Freeman, Abdelhadi Saoudi, Roland Liblau

J Neuroimmunol· August 2024

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Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells.
Trieu Le, Iuliia Ferling, Lanhui Qiu, Clement Nabaile, Leonardo Assunção, Spencer A Freeman

Dev Cell· April 2024

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Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes.
Dante Barreda, Sergio Grinstein, Spencer A Freeman

Eur J Cell Biol· March 2024

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Phytoplankton optical fingerprint libraries for development of phytoplankton ocean color satellite products.
Michael W Lomas, Aimee R Neeley, Ryan Vandermeulen, Antonio Mannino, Crystal Thomas, Scott A Freeman

Sci Data· February 2024

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Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes.
Sarah R Chadwick, Dante Barreda, Jing Ze Wu, Gang Ye, Bushra Yusuf, Spencer A Freeman

Proc Natl Acad Sci U S A· February 2024

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The resolution of phagosomes.
Sivakami Mylvaganam, Spencer A Freeman

Immunol Rev· October 2023

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Assessing Sustained B-Cell Depletion and Disease Activity in a French Multiple Sclerosis Cohort Treated by Long-Term IV Anti-CD20 Antibody Therapy.
Sean A Freeman, Bruno Lemarchant, Tifanie Alberto, Julie Boucher, Olivier Outteryck

Neurotherapeutics· October 2023

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ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution.
Jing Ze Wu, Mariia Zeziulia, Whijin Kwon, Thomas J Jentsch, Sergio Grinstein, Spencer A Freeman

J Cell Biol· June 2023

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Using Ion Substitution and Fluid Indicators to Monitor Macropinosome Dynamics in Live Cells.
Guillermo A de Paz Linares, Spencer A Freeman, Ruiqi Cai

Methods Mol Biol· June 2023

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Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E Steinberg, Yoshiro Saito, Spencer A Freeman

Curr Biol· April 2023

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