Publications by authors named "Spencer A Freeman"

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Is the Parkinson's-associated protein TMEM175 a proton channel: Yay or nay?
Spencer A Freeman, Sergio Grinstein

J Cell Biol· January 2026

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Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and bacterial extracellular vesicles.
Ava A Kavianpour, Sina Ghasempour, Kirsten J Meyer, Trieu Le, Ruiqi Cai, Spencer A Freeman

Curr Biol· September 2025

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The scaffolding and activation of NLRP3 on acidic vesicles depends on their biophysical properties and is independent of intermediate filaments.
Guillermo de Paz Linares, Jan Mossemann, Blayne Sayed, Spencer A Freeman

Mol Biol Cell· July 2025

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Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2.
Jing Ze Wu, Joshua G Pemberton, Shin Morioka, Junko Sasaki, Priya Bablani, Spencer A Freeman

J Cell Biol· June 2025

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The spectrum of lysosomal stress and damage responses: from mechanosensing to inflammation.
Ori Scott, Ekambir Saran, Spencer A Freeman

EMBO Rep· March 2025

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The neurorepellent SLIT2 inhibits LPS-induced proinflammatory signaling in macrophages.
Marko Skrtic, Bushra Yusuf, Sajedabanu Patel, Emily C Reddy, Kenneth K Y Ting, Spencer A Freeman

J Immunol· January 2025

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Human ITGAV variants are associated with immune dysregulation, brain abnormalities, and colitis.
Sina Ghasempour, Neil Warner, Rei Guan, Marco M Rodari, Danton Ivanochko, Spencer A Freeman

J Exp Med· December 2024

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Podosome Nucleation Is Facilitated by Multivalent Interactions between Syk and ITAM-containing Membrane Complexes.
Sina Ghasempour, Aleixo M Muise, Spencer A Freeman

J Immunol· October 2024

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Interleukin-1-mediated hyperinflammation in XIAP deficiency is associated with defective autophagy.
Dilan Dissanayake, Ashkan Firouzabady, Mohammad Massumi, Guillermo A de Paz Linares, Christian Marshall, Spencer A Freeman

Blood· September 2024

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Acidification of α-granules in megakaryocytes by vacuolar-type adenosine triphosphatase is essential for organelle biogenesis.
Chien-Yi Lu, Jing Ze Wu, Helen H Y Yao, Richard J Y Liu, Ling Li, Spencer A Freeman

J Thromb Haemost· August 2024

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Pressure sensing of lysosomes enables control of TFEB responses in macrophages.
Ruiqi Cai, Ori Scott, Gang Ye, Trieu Le, Ekambir Saran, Spencer A Freeman

Nat Cell Biol· August 2024

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Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells.
Trieu Le, Iuliia Ferling, Lanhui Qiu, Clement Nabaile, Leonardo Assunção, Spencer A Freeman

Dev Cell· April 2024

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Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes.
Dante Barreda, Sergio Grinstein, Spencer A Freeman

Eur J Cell Biol· March 2024

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Two-pore channels regulate endomembrane tension to enable remodeling and resolution of phagolysosomes.
Sarah R Chadwick, Dante Barreda, Jing Ze Wu, Gang Ye, Bushra Yusuf, Spencer A Freeman

Proc Natl Acad Sci U S A· February 2024

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The resolution of phagosomes.
Sivakami Mylvaganam, Spencer A Freeman

Immunol Rev· October 2023

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ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution.
Jing Ze Wu, Mariia Zeziulia, Whijin Kwon, Thomas J Jentsch, Sergio Grinstein, Spencer A Freeman

J Cell Biol· June 2023

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Using Ion Substitution and Fluid Indicators to Monitor Macropinosome Dynamics in Live Cells.
Guillermo A de Paz Linares, Spencer A Freeman, Ruiqi Cai

Methods Mol Biol· June 2023

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Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis.
Yusuke Hirata, Ruiqi Cai, Allen Volchuk, Benjamin E Steinberg, Yoshiro Saito, Spencer A Freeman

Curr Biol· April 2023

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The loss of glycocalyx integrity impairs complement factor H binding and contributes to cyclosporine-induced endothelial cell injury.
Chia Wei Teoh, Magdalena Riedl Khursigara, Carolina G Ortiz-Sandoval, Jee Woo Park, Jun Li, Spencer A Freeman

Front Med (Lausanne)· February 2023

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The glycocalyx and immune evasion in cancer.
Sina Ghasempour, Spencer A Freeman

FEBS J· January 2023

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Determinants, maintenance, and function of organellar pH.
Spencer A Freeman, Sergio Grinstein, John Orlowski

Physiol Rev· January 2023

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Dynamic glucose uptake, storage, and release by human microvascular endothelial cells.
Samaneh Yazdani, Philip J Bilan, Javier R Jaldin-Fincati, Janice Pang, Felicia Ceban, Spencer A Freeman

Mol Biol Cell· October 2022

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The spectrin cytoskeleton integrates endothelial mechanoresponses.
Sivakami Mylvaganam, Jonathan Plumb, Bushra Yusuf, Ren Li, Chien-Yi Lu, Spencer A Freeman

Nat Cell Biol· August 2022

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Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.
Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Spencer A Freeman

Nat Genet· February 2022

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ARPC1B binds WASP to control actin polymerization and curtail tonic signaling in B cells.
Gabriella Leung, Yuhuan Zhou, Philip Ostrowski, Sivakami Mylvaganam, Parastoo Boroumand, Spencer A Freeman

JCI Insight· December 2021

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