Publications by authors named "Sacha Howell"

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Anti-progestin therapy targets hallmarks of breast cancer risk.
Bruno M Simões, Robert Pedley, Curtis W McCloskey, Matthew Roberts, Austin D Reed, Anthony Howell, Sacha J Howell

Nature· December 2025

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Comparing percent breast density assessments of an AI-based method with expert reader estimates: inter-observer variability.
Stepan Romanov, Sacha Howell, Elaine Harkness, Dafydd Gareth Evans, Sue Astley

J Med Imaging (Bellingham)· November 2025

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Validation of the pathology-adjusted Manchester scoring system in over 10 000 assessments of cases with breast and/or ovarian cancer.
D Gareth Evans, Robert D Morgan, Claire Forde, Emma J Crosbie, George J Burghel, Anthony Howell, Sacha J Howell

J Med Genet· November 2025

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Randomised phase-2 screening trial of intermittent energy restriction plus resistance exercise versus resistance exercise alone during chemotherapy for advanced breast cancer.
Michelle Harvie, Mary Pegington, Anthony Howell, Yit Lim, Karen Livingstone, Sacha J Howell

Br J Cancer· October 2025

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Extending aromatase inhibitor treatment in early breast cancer; longer is better for many.
Sacha J Howell, Carlo Palmieri

Lancet· August 2025

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Radiation exposure of breast tissue in lymphoma radiotherapy: a systematic review of breast dose metrics published since 2000.
Hannah Chamberlin, Georgios Ntentas, David J Cutter, Richard Cowan, Sacha Howell

Acta Oncol· August 2025

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Re: Bridging Gaps in Remote Cancer Care: Commentary on the Adjuvant Abemaciclib Monitoring Model.
Nicole L Brown, Ann Tivey, Caroline Wilson, Fiona Britton, Sacha J Howell

Clin Breast Cancer· August 2025

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Development and Evaluation of a Remote Monitoring Regional Adjuvant Abemaciclib Service for Patients With High-Risk Early Breast Cancer.
Nicole L Brown, Ann Tivey, Suzanne Frank, Siow Chin Phua, Jack E Johnson, Sacha J Howell

Clin Breast Cancer· June 2025

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Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.
Maria Zanti, Denise G O'Mahony, Michael T Parsons, Leila Dorling, Joe Dennis, Sacha J Howell

Nat Commun· May 2025

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Integration of personalised ultrasensitive ctDNA monitoring of patients with metastatic breast cancer to reduce imaging requirements.
Pia Mouhanna, Anders Ståhlberg, Daniel Andersson, Ahmed Albu-Kareem, Ellinor Elinder, Sacha J Howell

Int J Cancer· April 2025

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Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib.
R C Coombes, Sacha Howell, Simon R Lord, Laura Kenny, Janine Mansi

Nat Commun· March 2025

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Capivasertib and fulvestrant for patients with HR-positive/HER2-negative advanced breast cancer: analysis of the subgroup of patients from Japan in the phase 3 CAPItello-291 trial.
Eriko Tokunaga, Hiroji Iwata, Mitsuya Itoh, Tetsuhiko Taira, Tatsuya Toyama, Sacha J Howell

Breast Cancer· January 2025

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Targeting Oestrogen Receptor Signalling in Breast Cancer Therapy.
Sacha J Howell, Anthony Howell

Adv Exp Med Biol· January 2025

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Long term follow-up of women treated for screen detected atypical ductal hyperplasia or lobular neoplasia in a large UK screening centre.
Nicole L Brown, Susan Pritchard, Elaine F Harkness, Yit Lim, Ashu Gandhi, Anthony Howell, Sacha J Howell

BJC Rep· December 2024

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Polygenic score distribution differences across European ancestry populations: implications for breast cancer risk prediction.
Kristia Yiangou, Nasim Mavaddat, Joe Dennis, Maria Zanti, Qin Wang, Sacha Howell, Anthony Howell

Breast Cancer Res· December 2024

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A plain language summary of the CAPItello-291 study: Capivasertib in hormone receptor-positive advanced breast cancer.
Nicholas C Turner, Mafalda Oliveira, Sacha J Howell, Florence Dalenc, Javier Cortés

Future Oncol· November 2024

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Experiences of a Digital Behavior Change Intervention to Prevent Weight Gain and Promote Risk-Reducing Health Behaviors for Women Aged 18 to 35 Years at Increased Risk of Breast Cancer: Qualitative Interview Study.
Rhiannon E Hawkes, Mary Pegington, Alan Davies, Julia Mueller, Anthony Howell, Sacha J Howell

JMIR Cancer· November 2024

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Can we utilise the circadian clock to target cancer stem cells?
Jia-Wen Lian, Shi-Yang Li, Robert B Clarke, Sacha J Howell, Qing-Jun Meng

Cancer Lett· November 2024

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Germline testing for breast cancer patients in England: illogical to prioritise grade 1 breast cancer aged 30-39 over grade 3 aged 40-49 years?
D Gareth Evans, Sacha J Howell, George J Burghel, Claire Forde, Fiona Lalloo, Anthony Howell

J Med Genet· September 2024

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Capivasertib and fulvestrant for patients with hormone receptor-positive, HER2-negative advanced breast cancer (CAPItello-291): patient-reported outcomes from a phase 3, randomised, double-blind, placebo-controlled trial.
Mafalda Oliveira, Hope S Rugo, Sacha J Howell, Florence Dalenc, Javier Cortes

Lancet Oncol· September 2024

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Development of a breast cancer risk assessment and primary prevention pathway for women aged 30-39 years: Views of UK primary care providers on the role of primary care.
Sarah Hindmarch, Louise Gorman, Juliet A Usher-Smith, Victoria G Woof, Sacha J Howell

PLoS One· September 2024

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Analysis of more than 400,000 women provides case-control evidence for and variant classification.
Maria Zanti, Denise G O'Mahony, Michael T Parsons, Leila Dorling, Joe Dennis, Sacha J Howell

medRxiv· September 2024

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Capability and reliability of deep learning models to make density predictions on low-dose mammograms.
Steven Squires, Alistair Mackenzie, Dafydd Gareth Evans, Sacha J Howell, Susan M Astley

J Med Imaging (Bellingham)· July 2024

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Population-based germline testing of , and in breast cancer patients in the United Kingdom: Evidence to support extended testing, and definition of groups who may not require testing.
D Gareth Evans, Emma R Woodward, George J Burghel, Sophie Allen, Beth Torr, Sacha J Howell, Anthony Howell

Genet Med Open· November 2023

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