Publications by authors named "Sachdev Sidhu"

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USP10/GSK3β-mediated inhibition of PTEN drives resistance to PI3K inhibitors in breast cancer.
Nishi Kumari, Sarah Ce Wright, Christopher M Witham, Laia Monserrat, Marta Palafox, Sachdev S Sidhu

J Clin Invest· November 2025

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Using phage display for rational engineering of a higher-affinity humanized 3' phosphohistidine-specific antibody.
Gregory D Martyn, Rajasree Kalagiri, Gianluca Veggiani, Robyn L Stanfield, Indrani Choudhuri, Sachdev S Sidhu

Commun Chem· November 2025

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An asymmetric tetrabody is a potent and efficacious agonist of the erythropoietin receptor in vitro and in vivo.
Jarrett J Adams, Levi L Blazer, Jacky Chung, Minoo Karimi, Taylor Davidson, Sachdev S Sidhu

Protein Sci· October 2025

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Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2.
Anju Wadhwa, Haley Johnson, Kondapa Naidu Bobba, Anil P Bidkar, Ellis Mayne, Sachdev S Sidhu

Res Sq· October 2025

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Locking CBL TKBD in its native conformation presents a novel therapeutic opportunity in mutant CBL-dependent leukemia.
Syed Feroj Ahmed, Jayanthi Anand, Wei Zhang, Lori Buetow, Loveena Rishi, Sachdev S Sidhu

Mol Ther· August 2025

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Effective imaging and treatment of Acute Myeloid Leukemia with radiotheranostics targeting the activated conformation of integrin-βeta2.
Anju Wadhwa, Haley Johnson, Kondapa Naidu Bobba, Anil P Bidkar, Ellis Mayne, Sachdev S Sidhu

bioRxiv· August 2025

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Molecular characterization of a synthetic neutralizing antibody targeting p67 of Theileria parva.
Shane Miersch, Alex U Singer, Chao Chen, Fred Fellouse, Anupriya Gopalsamy, Sachdev S Sidhu

Protein Sci· June 2025

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Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activation.
Jarrett J Adams, Heather A Bruce, Suryasree Subramania, Lynda Ploder, Julia Garcia, Sachdev S Sidhu

Protein Sci· June 2025

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Structural Survey of Antigen Recognition by Synthetic Human Antibodies.
Maryna Gorelik, Shane Miersch, Sachdev S Sidhu

Cold Spring Harb Protoc· February 2025

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Suppressing Tymovirus replication in plants using a variant of ubiquitin.
Anuradha De Silva, Kihun Kim, John Weiland, Jihyun Hwang, Jacky Chung, Sachdev S Sidhu

PLoS Pathog· January 2025

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Structural and biophysical characterisation of ubiquitin variants that inhibit the ubiquitin conjugating enzyme Ube2d2.
Jeffery M R B McAlpine, Jingyi Zhu, Nicholas Pudjihartono, Joan Teyra, Michael J Currie, Sachdev S Sidhu

FEBS J· December 2024

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Programming tissue-sensing T cells that deliver therapies to the brain.
Milos S Simic, Payal B Watchmaker, Sasha Gupta, Yuan Wang, Sharon A Sagan, Sachdev S Sidhu

Science· December 2024

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Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells.
Luiz Henrique Geraldo, Yunling Xu, Gaspard Mouthon, Jessica Furtado, Felipe Saceanu Leser, Sachdev S Sidhu

Sci Transl Med· November 2024

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Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Gregory D Martyn, Rajasree Kalagiri, Gianluca Veggiani, Robyn L Stanfield, Indrani Choudhuri, Sachdev S Sidhu

bioRxiv· November 2024

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Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones.
Heather A Bruce, Alexander U Singer, Levi L Blazer, Khanh Luu, Lynda Ploder, Sachdev S Sidhu

Protein Sci· July 2024

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Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling.
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Sachdev S Sidhu

Elife· May 2024

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Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification.
Andy Yang, Rony Chidiac, Emma Russo, Hendrik Steenland, Quinn Pauli, Sachdev S Sidhu

Development· March 2024

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Structural and functional validation of a highly specific Smurf2 inhibitor.
Tanner M Tessier, Arvid Chowdhury, Zane Stekel, Julia Fux, Maria Augusta Sartori, Sachdev S Sidhu

Protein Sci· February 2024

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Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
Heather A Bruce, Alexander U Singer, Ekaterina V Filippova, Levi L Blazer, Jarrett J Adams, Sachdev S Sidhu

Protein Sci· January 2024

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Author Correction: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
Edmond M Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Sachdev S Sidhu

Nat Commun· December 2023

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Structural surfaceomics reveals an AML-specific conformation of integrin β as a CAR T cellular therapy target.
Kamal Mandal, Gianina Wicaksono, Clinton Yu, Jarrett J Adams, Michael R Hoopmann, Sachdev S Sidhu

Nat Cancer· November 2023

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Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids.
Abdulkhaliq Alsaadi, Mara Artibani, Zhiyuan Hu, Nina Wietek, Matteo Morotti, Sachdev S Sidhu

Cell Rep· November 2023

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Cell-based passive immunization for protection against SARS-CoV-2 infection.
Evan Sawula, Shane Miersch, Eric D Jong, Chengjin Li, Fang-Yu Chou, Sachdev S Sidhu

Stem Cell Res Ther· November 2023

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Engineering SH2 Domains with Tailored Specificities and Affinities.
Gregory D Martyn, Gianluca Veggiani, Sachdev S Sidhu

Methods Mol Biol· September 2023

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Construction of Synthetic Antibody Phage Display Libraries.
Kim Anh Giang, Sachdev S Sidhu, Johan Nilvebrant

Methods Mol Biol· September 2023

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