Publications by authors named "Sachet A Shukla"

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A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.
Kathleen M Mahoney, Sachet A Shukla, Nikolaos Patsoukis, Apoorvi Chaudhri, Edward P Browne, Arnon Arazi, Thomas M Eisenhaure, William F Pendergraft, Ping Hua, Hung C Pham

March 2019

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PKCβ inhibitor MS-553 displays preclinical efficacy in both treatment-naïve and BTK inhibitor-resistant Chronic Lymphocytic Leukemia.
Britten K Gordon, Elizabeth M Muhowski, Jyotsana Singh, Janani Ravikrishnan, Arnau Peris-Cuesta, Sachet A Shukla

Blood Cancer Discov· November 2025

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A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.
Eryn Blass, Derin B Keskin, Chloe R Tu, Cleo Forman, Allison Vanasse, Sachet A Shukla

Cell· September 2025

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Tumor-Intrinsic and Microenvironmental Determinants of Impaired Antitumor Immunity in Chromophobe Renal Cell Carcinoma.
Chris Labaki, Eddy Saad, Katrine N Madsen, Charbel Hobeika, Kevin Bi, Sachet A Shukla

J Clin Oncol· August 2025

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Smoking habit and long-term colorectal cancer incidence by exome-wide mutational and neoantigen loads: evidence based on the prospective cohort incident-tumour biobank method.
Tsuyoshi Hamada, Tomotaka Ugai, Carino Gurjao, Satoko Ugai, Xuehong Zhang, Sachet A Shukla

BMJ Oncol· June 2025

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truncating mutations drive leukemic resistance to T cell attack.
Dustin McCurry, Zhongqi Ge, Jaehyun Lee, Rishi Pasumarthi, Xiaohong Leng, Sachet A Shukla

bioRxiv· June 2025

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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy.
Qinqin Jiang, David A Braun, Karl R Clauser, Vijyendra Ramesh, Nitin H Shirole, Sachet A Shukla

Cell· April 2025

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A neoantigen vaccine generates antitumour immunity in renal cell carcinoma.
David A Braun, Giorgia Moranzoni, Vipheaviny Chea, Bradley A McGregor, Eryn Blass, Sachet A Shukla

Nature· March 2025

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Immunogenomic determinants of exceptional response to immune checkpoint inhibition in renal cell carcinoma.
Tejas Jammihal, Renee Maria Saliby, Chris Labaki, Hanna Soulati, Juan Gallegos, Sachet A Shukla

Nat Cancer· February 2025

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Impact of renal cell carcinoma molecular subtypes on immunotherapy and targeted therapy outcomes.
Renée Maria Saliby, Chris Labaki, Tejas R Jammihal, Wanling Xie, Maxine Sun, Sachet A Shukla

Cancer Cell· May 2024

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ZNF683 marks a CD8 T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome.
Erin M Parry, Camilla K Lemvigh, Stephanie Deng, Nathan Dangle, Neil Ruthen, Sachet A Shukla

Cancer Cell· October 2023

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Germline variants associated with toxicity to immune checkpoint blockade.
Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Sachet A Shukla

Nat Med· December 2022

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Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.
Thomas Denize, Yue Hou, Jean-Christophe Pignon, Emily Walton, Destiny J West, Sachet A Shukla

Clin Cancer Res· September 2022

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Multidimensional Molecular Profiling of Metastatic Triple-Negative Breast Cancer and Immune Checkpoint Inhibitor Benefit.
Romualdo Barroso-Sousa, Juliet Forman, Katharine Collier, Zachary T Weber, Tejas R Jammihal, Sachet A Shukla

JCO Precis Oncol· July 2022

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Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche.
Pilar Baldominos, Alex Barbera-Mourelle, Olga Barreiro, Yu Huang, Andrew Wight, Sachet A Shukla

Cell· May 2022

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Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer.
Tamara Ouspenskaia, Travis Law, Karl R Clauser, Susan Klaeger, Siranush Sarkizova, Sachet A Shukla

Nat Biotechnol· February 2022

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HLA-A*03 and response to immune checkpoint blockade in cancer: an epidemiological biomarker study.
Vivek Naranbhai, Mathias Viard, Michael Dean, Stefan Groha, David A Braun, Sachet A Shukla

Lancet Oncol· January 2022

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Phenotype, specificity and avidity of antitumour CD8 T cells in melanoma.
Giacomo Oliveira, Kari Stromhaug, Susan Klaeger, Tomasz Kula, Dennie T Frederick, Sachet A Shukla

Nature· August 2021

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Alterations and Response to Immunotherapy in Solid Tumors.
Elio Adib, Amin H Nassar, Elie W Akl, Sarah Abou Alaiwi, Pier Vitale Nuzzo, Sachet A Shukla

Clin Cancer Res· July 2021

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Progressive immune dysfunction with advancing disease stage in renal cell carcinoma.
David A Braun, Kelly Street, Kelly P Burke, David L Cookmeyer, Thomas Denize, Sachet A Shukla

Cancer Cell· May 2021

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Genomic Alterations during the to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System.
Anne Trinh, Carlos R Gil Del Alcazar, Sachet A Shukla, Koei Chin, Young Hwan Chang

Mol Cancer Res· April 2021

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Expression of T-Cell Exhaustion Molecules and Human Endogenous Retroviruses as Predictive Biomarkers for Response to Nivolumab in Metastatic Clear Cell Renal Cell Carcinoma.
Miriam Ficial, Opeyemi A Jegede, Miriam Sant'Angelo, Yue Hou, Abdallah Flaifel, Sachet A Shukla

Clin Cancer Res· March 2021

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Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma.
Zhuting Hu, Donna E Leet, Rosa L Allesøe, Giacomo Oliveira, Shuqiang Li, Sachet A Shukla

Nat Med· March 2021

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Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.
Ziad Bakouny, David A Braun, Sachet A Shukla, Wenting Pan, Xin Gao

Nat Commun· February 2021

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Integrated Genomic Characterization of the Human Immunome in Cancer.
Yongsheng Li, Brandon Burgman, Daniel J McGrail, Ming Sun, Dan Qi, Sachet A Shukla

Cancer Res· November 2020

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Distinct evolutionary paths in chronic lymphocytic leukemia during resistance to the graft-versus-leukemia effect.
Pavan Bachireddy, Christina Ennis, Vinhkhang N Nguyen, Satyen H Gohil, Kendell Clement, Sachet A Shukla

Sci Transl Med· September 2020

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