PubHawk
March 2019 PMID 30564891

A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.

Kathleen M Mahoney, Sachet A Shukla, Nikolaos Patsoukis, Apoorvi Chaudhri, Edward P Browne, Arnon Arazi, Thomas M Eisenhaure, William F Pendergraft, Ping Hua, Hung C Pham, Xia Bu, Baogong Zhu, Nir Hacohen, Edward F Fritsch, Vassiliki A Boussiotis

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Mentions

7
Peak: 2 in Jun 2019
across 2 sources since May 2019

Extended reach

88,130
potential audience

Total likes

4

Video views

87

Mentions per month

May 2019 – Mar 2025

Where it's discussed

  • X / Twitter6 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions highlight the importance of the discovery, with phrases like 'game changer' and references to the variant’s ability to mediate immune suppression, illustrating high engagement and interest. Users are specifically intrigued by the covalent dimerization and potential therapeutic strategies, indicating a recognition of the research’s significant implications for cancer immunotherapy.

AgreementModerate agreement

Most discussions acknowledge the significance of the discovery, with many emphasizing its potential impact on cancer immunotherapy.

InterestHigh interest

Posts show high interest, with repeated mentions of the novel secreted PD-L1 splice variant and references to its role in immune suppression.

EngagementHigh engagement

There is deep engagement as users analyze the mechanisms, discuss implications for treatment, and reference the specific properties like covalent dimerization.

ImpactHigh impact

The discussions suggest this research could substantially influence future cancer treatments, highlighting its high potential impact.

Abstract in brief

  • The study identifies a new secreted form of PDL1, called secPDL1, which is produced through an alternative splicing process and lacks the transmembrane domain, allowing it to be released outside cells.
  • secPDL1 can form covalent homodimers thanks to a specific amino acid tail containing cysteine, making it more effective at suppressing immune responses compared to monomeric PDL1, and it can inhibit T-cell activity in laboratory experiments.
  • This variant is expressed in cancer cells and normal immune cells, especially activated myeloid cells, and may serve as a paracrine immune inhibitor within tumors, influencing immune suppression without needing direct cell-to-cell contact.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/9LtQwe7xT7

Aug 21, 2019 · 1 like · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/l0e1QbXy9j

May 26, 2019 · 1 like · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/ZE5n1Fn3wu

Jul 14, 2019 · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/t4vOqvQbf8

Jun 21, 2019 · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/pk4DP2CED5

Jun 16, 2019 · 17,062 followers View post →
Maria Robles
@RBioceutics · X

#cancer protects itself from immune attack in part by secreting soluble PD-L1. Need remove that extracorporeally by $SIGY or $AEMD devices https://t.co/IHYuRWlhda https://t.co/F9tYgx2hDZ

Mar 30, 2025 · 2,733 followers View post →

All mentions

Maria Robles
@RBioceutics · X

#cancer protects itself from immune attack in part by secreting soluble PD-L1. Need remove that extracorporeally by $SIGY or $AEMD devices https://t.co/IHYuRWlhda https://t.co/F9tYgx2hDZ

Mar 30, 2025 · 2,733 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/9LtQwe7xT7

Aug 21, 2019 · 1 like · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/ZE5n1Fn3wu

Jul 14, 2019 · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/t4vOqvQbf8

Jun 21, 2019 · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/pk4DP2CED5

Jun 16, 2019 · 17,062 followers View post →
Oncology Tube
@oncologytube · X

A Secreted PD-L1 Splice Variant that Covalently Dimerizes and Mediates Immunosuppression https://t.co/sGPB5b7uRc https://t.co/l0e1QbXy9j

May 26, 2019 · 1 like · 17,062 followers View post →