Publications by authors named "Sachin A Gupte"

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Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency.
Christina Signoretti, Samuel Fatehi, Rhonda Drewes, Francesca Cendali, Monika Dzieciatkowska, Sachin A Gupte

Am J Physiol Lung Cell Mol Physiol· December 2025

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Variant Increases the Risk of Developing VEGFR (Vascular Endothelial Growth Factor Receptor) Blocker-Induced Pulmonary Vascular Disease.
Christina Signoretti, Shun Matsumura, Samuel Fatehi, Melinee D'Silva, Rajamma Mathew, Sachin A Gupte

J Am Heart Assoc· October 2024

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Loss-of-function G6PD variant moderated high-fat diet-induced obesity, adipocyte hypertrophy, and fatty liver in male rats.
Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Sachin A Gupte

J Biol Chem· July 2024

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Global and endothelial G-protein coupled receptor 75 (GPR75) knockout relaxes pulmonary artery and mitigates hypoxia-induced pulmonary hypertension.
Catherine A D'Addario, Shun Matsumura, Atsushi Kitagawa, Gregg M Lainer, Frank Zhang, Sachin A Gupte

Vascul Pharmacol· December 2023

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Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells.
Amanda Krajnik, Erik Nimmer, Joseph A Brazzo, John C Biber, Rhonda Drewes, Sachin A Gupte

APL Bioeng· December 2023

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G6PD Orchestrates Genome-Wide DNA Methylation and Gene Expression in the Vascular Wall.
Christina Signoretti, Sachin A Gupte

Int J Mol Sci· November 2023

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The severity of SARS-CoV-2 infection in K18-hACE2 mice is attenuated by a novel steroid-derivative in a gender-specific manner.
Sachin A Gupte, Chandra Shekhar Bakshi, Emma Blackham, Gerald E Duhamel, Allan Jordan, Rakhee Gupte

Br J Pharmacol· October 2023

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Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall.
Christina Signoretti, Sachin A Gupte

bioRxiv· March 2023

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Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension.
Christina Jacob, Atsushi Kitagawa, Christina Signoretti, Monika Dzieciatkowska, Angelo D'Alessandro, Aaditya Gupte, Rakhee Gupte, Sachin A Gupte

J Biol Chem· December 2022

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Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness.
Shun Matsumura, Catherine D'Addiaro, Orazio J Slivano, Carmen De Miguel, Charles Stier, Rakhee Gupte, Sachin A Gupte

Vascul Pharmacol· August 2022

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G6PD is a critical enabler of hypoxia-induced accumulation of macrophages and platelets in mice lungs and contributor to lung inflammation.
Ryota Hashimoto, Sachin A Gupte

Vascul Pharmacol· June 2022

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Glucose-6-phosphate dehydrogenase and MEG3 controls hypoxia-induced expression of serum response factor (SRF) and SRF-dependent genes in pulmonary smooth muscle cell.
Atsushi Kitagawa, Christina Jacob, Sachin A Gupte

J Smooth Muscle Res· May 2022

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Differences in the expression of DNA methyltransferases and demethylases in leukocytes and the severity of pulmonary arterial hypertension between ethnic groups.
Catherine A D'Addario, Gregg M Lanier, Christina Jacob, Natalie Bauer, Jenny L Hewes, Sachin A Gupte

Physiol Rep· May 2022

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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia.
Atsushi Kitagawa, Christina Jacob, Allan Jordan, Ian Waddell, Ivan F McMurtry, Sachin A Gupte

J Pharmacol Exp Ther· May 2021

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G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases.
Vidhi Dhagia, Atsushi Kitagawa, Christina Jacob, Connie Zheng, Angelo D'Alessandro, Rakhee Gupte, Sachin A Gupte

Am J Physiol Heart Circ Physiol· March 2021

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CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean Variant.
Atsushi Kitagawa, Igor Kizub, Christina Jacob, Kevin Michael, Angelo D'Alessandro, Rakhee Gupte, Sachin A Gupte

Hypertension· August 2020

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Glucose-6-phosphate dehydrogenase increases Ca currents by interacting with Ca1.2 and reducing intrinsic inactivation of the L-type calcium channel.
Rakhee Gupte, Vidhi Dhagia, Petra Rocic, Rikuo Ochi, Sachin A Gupte

Am J Physiol Heart Circ Physiol· July 2020

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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation.
Sachindra Raj Joshi, Atsushi Kitagawa, Christina Jacob, Ryota Hashimoto, Vidhi Dhagia, Sachin A Gupte

Am J Physiol Lung Cell Mol Physiol· April 2020

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Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension.
Ryota Hashimoto, Gregg M Lanier, Vidhi Dhagia, Sachindra R Joshi, Allan Jordan, Sachin A Gupte

Am J Physiol Lung Cell Mol Physiol· February 2020

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Dehydroepiandrosterone inhibits I and its window current in voltage-dependent and -independent mechanisms in arterial smooth muscle cells.
Rikuo Ochi, Sukrutha Chettimada, Igor Kizub, Sachin A Gupte

Am J Physiol Heart Circ Physiol· December 2018

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CRISPR-Cas9-Mediated Epitope Tagging Provides Accurate and Versatile Assessment of Myocardin-Brief Report.
Qing Lyu, Vidhi Dhagia, Yu Han, Bing Guo, Mary E Wines-Samuelson, Sachin A Gupte

Arterioscler Thromb Vasc Biol· September 2018

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Corrigendum to "Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation" [J. Mol. Cell. Cardiol. 117 (2018) 88-99].
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Sachin A Gupte

J Mol Cell Cardiol· August 2018

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Elevated 20-HETE in metabolic syndrome regulates arterial stiffness and systolic hypertension via MMP12 activation.
Amanda Soler, Ian Hunter, Gregory Joseph, Rebecca Hutcheson, Brenda Hutcheson, Sachin A Gupte

J Mol Cell Cardiol· April 2018

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Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming.
Angelo D'Alessandro, Karim C El Kasmi, Lydie Plecitá-Hlavatá, Petr Ježek, Min Li, Sachin A Gupte

Antioxid Redox Signal· January 2018

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gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.
Ryota Hashimoto, Sachindra Raj Joshi, Houli Jiang, Jorge H Capdevila, Ivan F McMurtry, Sachin A Gupte

Am J Physiol Heart Circ Physiol· August 2017

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