Publications by authors named "Said Sebti"

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Geranylgeranyl transferase-1 inhibitor GGTI-2417 enhances the anti-tumour efficacy of histone deacetylase inhibitors in different T-cell lymphoma lines.
Xiaoyan Hu, Lin Li, Jewel Nkwocha, Hitesh Vasiyani, Aslamuzzaman Kazi, Said Sebti

Br J Haematol· December 2025

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Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.
Roberta Buono, Dennis Juarez, Madhuri Paul, Sarah J Skuli, Ian B Wong, Said M Sebti

bioRxiv· November 2025

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Chemoresistance of TP53 mutant acute myeloid leukemia requires the mevalonate byproduct, geranylgeranyl pyrophosphate, for induction of an adaptive stress response.
Sarah J Skuli, A'ishah Bakayoko, Marisa Kruidenier, Bryan Manning, Paige Pammer, Said M Sebti

Leukemia· September 2025

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Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I.
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Nanami Ogino, Yoshihisa Inoue, Said M Sebti

Chemistry· May 2025

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FGTI-2734 Inhibits ERK Reactivation to Overcome Sotorasib Resistance in KRAS G12C Lung Cancer.
Aslamuzzaman Kazi, Hitesh Vasiyani, Deblina Ghosh, Dipankar Bandyopadhyay, Rachit D Shah, Said M Sebti

J Thorac Oncol· March 2025

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Correction: CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function.
Justin C Boucher, Gongbo Li, Hiroshi Kotani, Maria L Cabral, Dylan Morrissey, Said M Sebti

Cancer Immunol Res· December 2024

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Correction: Porphyrin overdrive rewires cancer cell metabolism.
Swamy R Adapa, Gregory A Hunter, Narmin E Amin, Christopher Marinescu, Andrew Borsky, Said M Sebti

Life Sci Alliance· August 2024

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Porphyrin overdrive rewires cancer cell metabolism.
Swamy R Adapa, Gregory A Hunter, Narmin E Amin, Christopher Marinescu, Andrew Borsky, Said M Sebti

Life Sci Alliance· July 2024

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Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of Pancreatic Cancer Patient-derived Tumors.
Aslamuzzaman Kazi, Alok Ranjan, Vasantha Kumar M V, Bogos Agianian, Martin Garcia Chavez, Said M Sebti

Cancer Res Commun· December 2023

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Inhibiting Isoprenylation Suppresses FcεRI-Mediated Mast Cell Function and Allergic Inflammation.
Jordan M Dailey, Sydney A Kee, Anuj Tharakan, Aslamuzzaman Kazi, Jason R Burchett, Said M Sebti

J Immunol· August 2023

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Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers.
Katarzyna M Tyc, Aslamuzzaman Kazi, Alok Ranjan, Rui Wang, Said M Sebti

iScience· March 2023

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Apatite phosphate doped by cobalt as hight efficient catalyst of multi-component synthesis of therapeutic spiropyrimidine compound.
Abdallah Rhihil, Youness Aichi, Mohamed Zahouily, Saïd Sebti, Mohamed El Guendouzi

Nat Prod Bioprospect· September 2022

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Dual JAK2/Aurora kinase A inhibition prevents human skin graft rejection by allo-inactivation and ILC2-mediated tissue repair.
Kelly Walton, Kirsti Walker, Megan Riddle, Brent H Koehn, Jordan Reff, Said M Sebti

Am J Transplant· March 2022

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Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells.
Liang Zhou, Xinyan Pei, Yu Zhang, Yanxia Ning, Lin Li, Said M Sebti

Mol Cancer Res· March 2022

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Global Phosphoproteomics Reveal CDK Suppression as a Vulnerability to KRas Addiction in Pancreatic Cancer.
Aslamuzzaman Kazi, Liwei Chen, Shengyan Xiang, Rajanikanth Vangipurapu, Hua Yang, Saïd M Sebti

Clin Cancer Res· July 2021

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Pacritinib Combined with Sirolimus and Low-Dose Tacrolimus for GVHD Prevention after Allogeneic Hematopoietic Cell Transplantation: Preclinical and Phase I Trial Results.
Joseph Pidala, Kelly Walton, Hany Elmariah, Jongphil Kim, Asmita Mishra, Said M Sebti

Clin Cancer Res· May 2021

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CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function.
Justin C Boucher, Gongbo Li, Hiroshi Kotani, Maria L Cabral, Dylan Morrissey, Said M Sebti

Cancer Immunol Res· January 2021

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Metabolic reprogramming augments potency of human pSTAT3-inhibited iTregs to suppress alloreactivity.
Kelly Walton, Mario R Fernandez, Elizabeth M Sagatys, Jordan Reff, Jongphil Kim, Said M Sebti

JCI Insight· May 2020

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The GTPase KRAS suppresses the p53 tumor suppressor by activating the NRF2-regulated antioxidant defense system in cancer cells.
Hua Yang, Shengyan Xiang, Aslamuzzaman Kazi, Said M Sebti

J Biol Chem· March 2020

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Dual Farnesyl and Geranylgeranyl Transferase Inhibitor Thwarts Mutant KRAS-Driven Patient-Derived Pancreatic Tumors.
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Liwei Chen, Perry Kennedy, Said M Sebti

Clin Cancer Res· October 2019

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A Phase I Study of GGTI-2418 (Geranylgeranyl Transferase I Inhibitor) in Patients with Advanced Solid Tumors.
Thomas B Karasic, E Gabriela Chiorean, Said M Sebti, Peter J O'Dwyer

Target Oncol· October 2019

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Vitamin E δ-tocotrienol sensitizes human pancreatic cancer cells to TRAIL-induced apoptosis through proteasome-mediated down-regulation of c-FLIP.
Rony A Francois, Anying Zhang, Kazim Husain, Chen Wang, Sean Hutchinson, Said M Sebti

Cancer Cell Int· July 2019

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GSK3 suppression upregulates β-catenin and c-Myc to abrogate KRas-dependent tumors.
Aslamuzzaman Kazi, Shengyan Xiang, Hua Yang, Daniel Delitto, José Trevino, Saïd M Sebti

Nat Commun· December 2018

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Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.
Michele Carbone, Ivano Amelio, El Bachir Affar, James Brugarolas, Lisa A Cannon-Albright, Said M Sebti

Cell Death Differ· November 2018

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PTEN counteracts FBXL2 to promote IP3R3- and Ca-mediated apoptosis limiting tumour growth.
Shafi Kuchay, Carlotta Giorgi, Daniele Simoneschi, Julia Pagan, Sonia Missiroli, Said M Sebti

Nature· June 2017

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