Publications by authors named "Saima Muzaffar"

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Probing -substituted 4-(5-mercapto-4-ethyl-4H-1,2,4-triazol-3-yl)--phenylpiperdine-1-carboxamides as potent 15-LOX inhibitors supported with ADME, DFT calculations and molecular docking studies.
Zahid Nawaz, Naheed Riaz, Muhammad Saleem, Ambar Iqbal, Syeda Abida Ejaz, Saima Muzaffar

Heliyon· September 2024

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Molecular hybrids of substituted phenylcarbamoylpiperidine and 1,2,4-triazole methylacetamide as potent 15-LOX inhibitors: Design, synthesis, DFT calculations and molecular docking studies.
Zahid Nawaz, Naheed Riaz, Muhammad Saleem, Ambar Iqbal, Syeda Abida Ejaz, Saima Muzaffar

Bioorg Chem· February 2024

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Targeting new N-furfurylated 4-chlorophenyl-1,2,4-triazolepropionamide hybrids as potential 15-lipoxygenase inhibitors supported with and studies.
Muhammad Yasin, Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Saima Muzaffar

J Biomol Struct Dyn· July 2023

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Assessing p-tolyloxy-1,3,4-oxadiazole acetamides as lipoxygenase inhibitors assisted by in vitro and in silico studies.
Bushra Bashir, Naheed Riaz, Syeda Abida Ejaz, Muhammad Saleem, Muhammad Ashraf, Saima Muzaffar

Bioorg Chem· December 2022

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4-Chlorophenyl--furfuryl-1,2,4-triazole Methylacetamides as Significant 15-Lipoxygenase Inhibitors: an Efficient Approach for Finding Lead Anti-inflammatory Compounds.
Muhammad Yasin, Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Saima Muzaffar

ACS Omega· June 2022

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The effect of 24-week belimumab treatment withdrawal followed by treatment restart in patients with SLE: an open-label, non-randomised 52-week study.
Sang-Cheol Bae, Damon L Bass, Myron Chu, Paula Curtis, Richard Dimelow, Saima Muzaffar

Arthritis Res Ther· February 2022

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Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies.
Bushra Bashir, Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Aziz-Ur-Rehman, Saima Muzaffar

Bioorg Chem· October 2021

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Exploring phenylcarbamoylazinane-1,2,4-triazole thioethers as lipoxygenase inhibitors supported with in vitro, in silico and cytotoxic studies.
Wardah Shahid, Muhammad Ashraf, Muhammad Saleem, Bushra Bashir, Saima Muzaffar

Bioorg Chem· October 2021

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Probing phenylcarbamoylazinane-1,2,4-triazole amides derivatives as lipoxygenase inhibitors along with cytotoxic, ADME and molecular docking studies.
Saima Muzaffar, Wardah Shahid, Naheed Riaz, Muhammad Saleem, Muhammad Ashraf

Bioorg Chem· February 2021

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NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.
Saima Muzaffar, Jamie Y Jeremy, Gianni D Angelini, Nilima Shukla

J Cell Physiol· May 2012

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NADPH oxidase 1 mediates upregulation of thromboxane A2 synthase in human vascular smooth muscle cells: inhibition with iloprost.
Saima Muzaffar, Nilima Shukla, Yolanda Massey, Gianni D Angelini, Jamie Y Jeremy

Eur J Pharmacol· May 2011

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Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells.
Saima Muzaffar, Nilima Shukla, Mark Bond, Andrew C Newby, Gianni D Angelini

J Vasc Res· November 2008

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Possible mechanisms underlying the effects of inhaled nitric oxide.
Nilima Shukla, Saima Muzaffar, Gianni D Angelini, Kai Zacharowski, Jamie Y Jeremy

Anesthesiology· October 2007

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Superoxide auto-augments superoxide formation and upregulates gp91(phox) expression in porcine pulmonary artery endothelial cells: inhibition by iloprost.
Saima Muzaffar, Nilima Shukla, Gianni D Angelini, Jamie Y Jeremy

Eur J Pharmacol· May 2006

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Sexual dysfunction and cardiac risk (the second Princeton Concensus Conference).
Jamie Y Jeremy, Saima Muzaffar, Anthony J Koupparis, Gianni D Angelini, Raj Persad

Am J Cardiol· December 2005

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Nicotinamide adenine dinucleotide phosphate oxidase: a promiscuous therapeutic target for cardiovascular drugs?
Saima Muzaffar, Nilima Shukla, Jamie Y Jeremy

Trends Cardiovasc Med· November 2005

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Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells.
Saima Muzaffar, Nilima Shukla, Amit Srivastava, Gianni D Angelini, Jamie Y Jeremy

Br J Pharmacol· September 2005

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Sildenafil inhibits the formation of superoxide and the expression of gp47 NAD[P]H oxidase induced by the thromboxane A2 mimetic, U46619, in corpus cavernosal smooth muscle cells.
Anthony J Koupparis, Jamie Y Jeremy, Saima Muzaffar, Raj Persad, Nilima Shukla

BJU Int· August 2005

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Prednisolone augments superoxide formation in porcine pulmonary artery endothelial cells through differential effects on the expression of nitric oxide synthase and NADPH oxidase.
Saima Muzaffar, Nilima Shukla, Gianni D Angelini, Jamie Y Jeremy

Br J Pharmacol· July 2005

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Is the therapeutic action of sildenafil mediated partly through the inhibition of superoxide formation?
Jamie Y Jeremy, Anthony Koupparis, Saima Muzaffar, Raj Persad, Gianni D Angelini

BJU Int· May 2005

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Regarding "Serum total 8-iso-prostaglandin F2alpha: a new and independent predictor of peripheral arterial disease".
Jaime Y Jeremy, Saima Muzaffar, Gianni D Angelini, Nilima Shukla

J Vasc Surg· February 2005

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Inhaled prostacyclin is safe, effective, and affordable in patients with pulmonary hypertension, right-heart dysfunction, and refractory hypoxemia after cardiothoracic surgery.
Saima Muzaffar, Nilima Shukla, Gianni D Angelini, Jamie Y Jeremy

J Thorac Cardiovasc Surg· December 2004

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Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells.
Saima Muzaffar, Nilima Shukla, Gianni Angelini, Jamie Y Jeremy

Circulation· August 2004

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Reactive oxygen species, vascular disease and cardiovascular surgery.
Jamie Y Jeremy, Nilima Shukla, Saima Muzaffar, Alexandra Handley, Gianni D Angelini

Curr Vasc Pharmacol· July 2004

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Iloprost inhibits superoxide formation and gp91phox expression induced by the thromboxane A2 analogue U46619, 8-isoprostane F2alpha, prostaglandin F2alpha, cytokines and endotoxin in the pig pulmonary artery.
Saima Muzaffar, Nilima Shukla, Clinton Lobo, Gianni D Angelini, Jamie Y Jeremy

Br J Pharmacol· February 2004

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