Publications by authors named "Sakthi D Moorthy"

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A Sox2 enhancer cluster regulates region-specific neural fates from mouse embryonic stem cells.
Ian C Tobias, Sakthi D Moorthy, Virlana M Shchuka, Lida Langroudi, Mariia Cherednychenko

G3 (Bethesda)· April 2025

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The cells are all-right: Regulation of the Lefty genes by separate enhancers in mouse embryonic stem cells.
Tiegh Taylor, Hongyu Vicky Zhu, Sakthi D Moorthy, Nawrah Khader, Jennifer A Mitchell

PLoS Genet· December 2024

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Enhancer-promoter interactions can bypass CTCF-mediated boundaries and contribute to phenotypic robustness.
Shreeta Chakraborty, Nina Kopitchinski, Zhenyu Zuo, Ariel Eraso, Parirokh Awasthi, Sakthi D Moorthy

Nat Genet· February 2023

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Transcriptional regulation and chromatin architecture maintenance are decoupled functions at the locus.
Tiegh Taylor, Natalia Sikorska, Virlana M Shchuka, Sanjay Chahar, Chenfan Ji, Sakthi D Moorthy

Genes Dev· June 2022

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Transcriptional enhancers: from prediction to functional assessment on a genome-wide scale.
Ian C Tobias, Luis E Abatti, Sakthi D Moorthy, Shanelle Mullany, Tiegh Taylor

Genome· April 2021

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A flexible repertoire of transcription factor binding sites and a diversity threshold determines enhancer activity in embryonic stem cells.
Gurdeep Singh, Shanelle Mullany, Sakthi D Moorthy, Richard Zhang, Tahmid Mehdi

Genome Res· April 2021

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Wucherria bancrofti glutathione S-Transferase: Insights into the 2.3 Å resolution X-ray structure and function, a therapeutic target for human lymphatic filariasis.
Prince Rajaiah Prabhu, Sakthi Devi Moorthy, Jayaprakasam Madhumathi, Satya Narayan Pradhan, Markus Perbandt

Biochem Biophys Res Commun· November 2018

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Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes.
Sakthi D Moorthy, Scott Davidson, Virlana M Shchuka, Gurdeep Singh, Nakisa Malek-Gilani

Genome Res· February 2017

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Generating CRISPR/Cas9 Mediated Monoallelic Deletions to Study Enhancer Function in Mouse Embryonic Stem Cells.
Sakthi D Moorthy, Jennifer A Mitchell

J Vis Exp· April 2016

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Chromatin Dynamics in Lineage Commitment and Cellular Reprogramming.
Virlana M Shchuka, Nakisa Malek-Gilani, Gurdeep Singh, Lida Langroudi, Navroop K Dhaliwal, Sakthi D Moorthy

Genes (Basel)· July 2015

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