Publications by authors named "Sam Lear"

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De novo discovery of cyclic peptide inhibitors of IL-11 signaling.
Sam Lear, Rosalba Tafi, Valentina A Di Biasio, Petro Halkowycz, Ruhi Kamran

Bioorg Med Chem· March 2025

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Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity.
Sam Lear, Elsa Pflimlin, Zhihong Zhou, David Huang, Sharon Weng

J Med Chem· September 2020

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Recombinant Expression and Stapling of a Novel Long-Acting GLP-1R Peptide Agonist.
Sam Lear, Hyosuk Seo, Candy Lee, Lei Lei, Zaid Amso

Molecules· May 2020

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Engineering PEG-fatty acid stapled, long-acting peptide agonists for G protein-coupled receptors.
Sam Lear, Zaid Amso, Weijun Shen

Methods Enzymol· February 2020

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Molecular interaction site on procoagulant myosin for factor Xa-dependent prothrombin activation.
Hiroshi Deguchi, Zihan Guo, Mohammed Hayat, Elsa Pflimlin, Sam Lear

J Biol Chem· October 2019

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Design of a Long-Acting and Selective MEG-Fatty Acid Stapled Prolactin-Releasing Peptide Analog.
Elsa Pflimlin, Sam Lear, Candy Lee, Shan Yu, Huafei Zou

ACS Med Chem Lett· August 2019

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Pep-Calc.com: a set of web utilities for the calculation of peptide and peptoid properties and automatic mass spectral peak assignment.
Sam Lear, Steven L Cobb

J Comput Aided Mol Des· March 2016

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Directional Plk1 inhibition-driven cell cycle interruption using amphiphilic thin-coated peptide-lanthanide upconversion nanomaterials as in vivo tumor suppressors.
Chi-Fai Chan, Rongfeng Lan, Ming-Kiu Tsang, Di Zhou, Sam Lear

J Mater Chem B· April 2015

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Monitoring and inhibition of Plk1: amphiphilic porphyrin conjugated Plk1 specific peptides for its imaging and anti-tumor function.
Hongguang Li, Chi-Fai Chan, Wai-Lun Chan, Sam Lear, Steven L Cobb

Org Biomol Chem· August 2014

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