Publications by authors named "Sameer Issaq"

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Targeting NAD+ Metabolism Vulnerability in FH-Deficient Hereditary Leiomyomatosis and Renal Cell Carcinoma with the Novel NAMPT Inhibitor OT-82.
Susana S Najera, Christopher J Ricketts, Laura S Schmidt, Julia I Medina, Keita Saito, Sameer H Issaq

Mol Cancer Ther· February 2025

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Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models.
Grace B McKay-Corkum, Victor J Collins, Choh Yeung, Takeshi Ito, Sameer H Issaq

Clin Cancer Res· November 2023

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 induces DNA damage, cell death, and suppression of tumor growth in preclinical models of Ewing sarcoma.
Anna E Gibson, Choh Yeung, Sameer H Issaq, Victor J Collins, Michael Gouzoulis

Oncogenesis· September 2020

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EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Sameer H Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I Rosales, Damien Y Duveau

Mol Cancer Ther· July 2020

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Targeting metabolic dependencies in pediatric cancer.
Sameer H Issaq, Christine M Heske

Curr Opin Pediatr· February 2020

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Choh Yeung, Anna E Gibson, Sameer H Issaq, Nobu Oshima, Joshua T Baumgart

Cancer Res· October 2019

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Glutamine synthetase is necessary for sarcoma adaptation to glutamine deprivation and tumor growth.
Sameer H Issaq, Arnulfo Mendoza, Stephen D Fox, Lee J Helman

Oncogenesis· February 2019

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Metabolomics uncovers a link between inositol metabolism and osteosarcoma metastasis.
Ling Ren, Ellen S Hong, Arnulfo Mendoza, Sameer Issaq, Christine Tran Hoang

Oncotarget· June 2017

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Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
Sameer H Issaq, Beverly A Teicher, Anne Monks

Cell Cycle· May 2016

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The in vivo role of the RP-Mdm2-p53 pathway in signaling oncogenic stress induced by pRb inactivation and Ras overexpression.
Wenqi Pan, Sameer Issaq, Yanping Zhang

PLoS One· November 2011

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Sec5 and Exo84 foster oncogenic ras-mediated tumorigenesis.
Sameer H Issaq, Kian-Huat Lim, Christopher M Counter

Mol Cancer Res· February 2010

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