Publications by authors named "Samia M Mostafa"

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Exploitation of novel pyrazolo[3,4-d]pyrimidine scaffold tethered to thiazole as potential EGFR/HER2 dual kinase inhibitor to overcome lapatinib resistant breast cancer: Design, synthesis, in silico docking and molecular dynamic simulation.
Ibrahim M Salem, Osama I El-Sabbagh, Samia M Mostafa, Ismail Salama, Mohammed A Al-Awadh

Bioorg Chem· August 2025

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Revealing Pharmacokinetic Interactions of Tramadol, Tapentadol, and Venlafaxine: A Cutting-Edge Liquid Chromatography-Tandem Mass Spectrometry Analytical Approach in Rat Plasma.
Hala M Heneedak, Khaled M Darwish, Samia M Mostafa, Mohamed Saleh Elgawish

ACS Pharmacol Transl Sci· April 2025

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Green innovation in analytical chemistry: A sustainable densitometric HPTLC approach for the distinctive separation and quantification of structurally related abused drugs - tramadol, tapentadol, and venlafaxine - in seized pharmaceutical dosage forms.
Hala M Heneedak, Mohamed A Abdelshakour, Khaled M Darwish, Samia M Mostafa, Mohamed Saleh Elgawish

J Pharm Biomed Anal· June 2024

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Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors.
Ibrahim M Salem, Samia M Mostafa, Ismail Salama, Osama I El-Sabbagh, Wael A H Hegazy

J Enzyme Inhib Med Chem· December 2023

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Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo[3,4-d]pyrimidines: Synthesis, antitumor evaluation and molecular modeling study.
Ibrahim M Salem, Samia M Mostafa, Ismail Salama, Osama I El-Sabbagh, Wael A H Hegazy

Bioorg Chem· December 2022

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Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein.
Manar I Nagy, Khaled M Darwish, Safaa M Kishk, Mohamed A Tantawy, Ali M Nasr, Samia M Mostafa

Pharmaceuticals (Basel)· February 2021

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The Anticancer Activity for the Bumetanide-Based Analogs via Targeting the Tumor-Associated Membrane-Bound Human Carbonic Anhydrase-IX Enzyme.
Azizah M Malebari, Tarek S Ibrahim, Ibrahim M Salem, Ismail Salama, Ahdab N Khayyat, Samia M Mostafa

Pharmaceuticals (Basel)· September 2020

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Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold.
Tarek S Ibrahim, Ibrahim M Salem, Samia M Mostafa, Osama I El-Sabbagh, Mohamed K M ElKhamisi

Bioorg Chem· July 2020

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Liquid chromatography tandem mass spectrometry for the simultaneous determination of metformin and pioglitazone in rat plasma: Application to pharmacokinetic and drug-drug interaction studies.
Mohamed Saleh Elgawish, Sally Nasser, Ismail Salama, Abbas Mamdoh Abbas, Samia M Mostafa

J Chromatogr B Analyt Technol Biomed Life Sci· August 2019

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Design and Synthesis of Imidazole and Triazole Pyrazoles as CYP121A1 Inhibitors.
Safaa M Kishk, Kirsty J McLean, Sakshi Sood, Darren Smith, Jack W D Evans, Samia M Mostafa

ChemistryOpen· July 2019

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Development and validation of an HPLC-UV method for simultaneous determination of sildenafil and tramadol in biological fluids: Application to drug-drug interaction study.
Hosam Eldin Dahshan, Mohamed A Helal, Samia M Mostafa, Mohamed Saleh Elgawish

J Pharm Biomed Anal· May 2019

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Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1.
Safaa M Kishk, Kirsty J McLean, Sakshi Sood, Mohamed A Helal, Mohamed S Gomaa, Samia M Mostafa

Bioorg Med Chem· April 2019

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Simple and rapid HPLC method for simultaneous determination of atenolol and chlorthalidone in spiked human plasma.
Mohamed S Elgawish, Samia M Mostafa, Abdalla A Elshanawane

Saudi Pharm J· January 2011

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Development and validation of an LC method for simultaneous determination of amiloride hydrochloride and hydrochlorothiazide in human urine.
Abdalla A Elshanawane, Samia M Mostafa, Mohamed S Elgawish

J AOAC Int· August 2009

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Development and validation of a reversed-phase high-performance liquid chromatographic method for the simultaneous determination of amiloride hydrochloride, atenolol, hydrochlorothiazide, and chlorthalidone in their combined mixtures.
Abdalla A Elshanawane, Samia M Mostafa, Mohamed S Elgawish

J AOAC Int· July 2009

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