Publications by authors named "Samuel B Stephens"

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Proinflammatory Cytokines Mediate Pancreatic β-Cell-Specific Alterations to Golgi Integrity via iNOS-Dependent Mitochondrial Inhibition.
Sandra E Blom, Palin R Narsian, Riley M Behan-Bush, James A Ankrum, Ling Yang, Samuel B Stephens

Diabetes· November 2025

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IER3IP1 Mutations Cause Neonatal Diabetes Due to Impaired Proinsulin Trafficking.
Hossam Montaser, Sonja Leppänen, Eliisa Vähäkangas, Nils Bäck, Alicia Grace, Samuel B Stephens

Diabetes· April 2025

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Breaking the Feedback Loop of β-Cell Failure: Insight into the Pancreatic β-Cell's ER-Mitochondria Redox Balance.
Amira Zaher, Samuel B Stephens

Cells· March 2025

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Proinflammatory cytokines mediate pancreatic β-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition.
Sandra E Blom, Riley M Behan-Bush, James A Ankrum, Ling Yang, Samuel B Stephens

bioRxiv· January 2025

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Defining Cytokine Responsive and Non-responsive Human β-cells.
Samuel B Stephens

Function (Oxf)· September 2024

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A metabolic redox relay supports ER proinsulin export in pancreatic islet β cells.
Kristen E Rohli, Nicole J Stubbe, Emily M Walker, Gemma L Pearson, Scott A Soleimanpour, Samuel B Stephens

JCI Insight· June 2024

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The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis.
Marcel S Woo, Lukas C Bal, Ingo Winschel, Elias Manca, Mark Walkenhorst, Samuel B Stephens

J Clin Invest· June 2024

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Loss of the Golgi-localized v-ATPase subunit does not alter insulin granule formation or pancreatic islet β-cell function.
Cierra K Boyer, Sandra E Blom, Ashleigh E Machado, Kristen E Rohli, Michelle E Maxson, Samuel B Stephens

Am J Physiol Endocrinol Metab· March 2024

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Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation.
Nancy Sue, Le May Thai, Atsushi Saito, Cierra K Boyer, Ashleigh M Fordham, Samuel B Stephens

Mol Metab· January 2024

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Utilization of commercial collagens for preparing well-differentiated human beta cells for confocal microscopy.
Brianna R Brennecke, USeong Yang, Siming Liu, Fatma S Ilerisoy, Beyza N Ilerisoy, Samuel B Stephens

Front Endocrinol (Lausanne)· June 2023

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Synchronized proinsulin trafficking reveals delayed Golgi export accompanies β-cell secretory dysfunction in rodent models of hyperglycemia.
Cierra K Boyer, Casey J Bauchle, Jianchao Zhang, Yanzhuang Wang, Samuel B Stephens

Sci Rep· March 2023

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ER Redox Homeostasis Regulates Proinsulin Trafficking and Insulin Granule Formation in the Pancreatic Islet β-Cell.
Kristen E Rohli, Cierra K Boyer, Shelby C Bearrows, Marshall R Moyer, Weston S Elison, Samuel B Stephens

Function (Oxf)· January 2023

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Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules.
Anup Parchure, Meng Tian, Danièle Stalder, Cierra K Boyer, Shelby C Bearrows, Samuel B Stephens

J Cell Biol· December 2022

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Nutrient Regulation of Pancreatic Islet β-Cell Secretory Capacity and Insulin Production.
Kristen E Rohli, Cierra K Boyer, Sandra E Blom, Samuel B Stephens

Biomolecules· February 2022

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A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.
Mark Li, Fan Shao, Qingwen Qian, Wenjie Yu, Zeyuan Zhang, Samuel B Stephens

Mol Ther Nucleic Acids· December 2021

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Mitochondrial Efflux of Citrate and Isocitrate Is Fully Dispensable for Glucose-Stimulated Insulin Secretion and Pancreatic Islet β-Cell Function.
Casey J Bauchle, Kristen E Rohli, Cierra K Boyer, Vidhant Pal, Jonathan V Rocheleau, Samuel B Stephens

Diabetes· August 2021

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RABL6A Promotes Pancreatic Neuroendocrine Tumor Angiogenesis and Progression In Vivo.
Chandra K Maharjan, Shaikamjad Umesalma, Courtney A Kaemmer, Viviane P Muniz, Casey Bauchle, Samuel B Stephens

Biomedicines· June 2021

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β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
Frank K Huynh, Brett S Peterson, Kristin A Anderson, Zhihong Lin, Aeowynn J Coakley, Samuel B Stephens

Am J Physiol Endocrinol Metab· October 2020

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Adipose Triglyceride Lipase Is a Key Lipase for the Mobilization of Lipid Droplets in Human β-Cells and Critical for the Maintenance of Syntaxin 1a Levels in β-Cells.
Siming Liu, Joseph A Promes, Mikako Harata, Akansha Mishra, Samuel B Stephens

Diabetes· June 2020

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The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells.
Terry C Yin, Casey J Bauchle, Alix A J Rouault, Samuel B Stephens, Julien A Sebag

iScience· June 2020

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Adipose Triglyceride Lipase is a Key Lipase for the Mobilization of Lipid Droplets in Human Beta Cells and Critical for the Maintenance of Syntaxin1a Level in Beta Cells.
Siming Liu, Joseph A Promes, Mikako Harata, Akansha Mishra, Samuel B Stephens

Diabetes· March 2020

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Chromogranin B regulates early-stage insulin granule trafficking from the Golgi in pancreatic islet β-cells.
Shelby C Bearrows, Casey J Bauchle, McKenzie Becker, Jonathan M Haldeman, Svetha Swaminathan, Samuel B Stephens

J Cell Sci· July 2019

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SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.
Chen Kang, Litao Xie, Susheel K Gunasekar, Anil Mishra, Yanhui Zhang, Samuel B Stephens

Nat Commun· January 2018

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The Prohormone VGF Regulates β Cell Function via Insulin Secretory Granule Biogenesis.
Samuel B Stephens, Robert J Edwards, Masato Sadahiro, Wei-Jye Lin, Cheng Jiang

Cell Rep· September 2017

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Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival.
Heather L Hayes, Brett S Peterson, Jonathan M Haldeman, Christopher B Newgard, Hans E Hohmeier, Samuel B Stephens

PLoS One· August 2017

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