Publications by authors named "Samuel Lessard"

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Genetic liability to psoriasis predicts severe disease outcomes.
Jake R Saklatvala, Samuel Lessard, Maris Teder-Laving, Laurent F Thomas, Ravi Ramessur

Genome Med· December 2025

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Selective AMPKβ1 activation induces fetal hemoglobin in human erythroid cells and sickle cell mice via the noncanonical NRF2 pathway.
Yannis Hara, Viktor T Lemgart, Samuel Lessard, Courtney J Mercadante, Jean-Antoine Ribeil

Sci Adv· November 2025

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Building a human genetic data lake to scale up insights for drug discovery.
Clement Chatelain, Samuel Lessard, Katherine Klinger, Shameer Khader, Emanuele de Rinaldis

Drug Discov Today· June 2025

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Leveraging large-scale multi-omics evidences to identify therapeutic targets from genome-wide association studies.
Samuel Lessard, Michael Chao, Kadri Reis, ,

BMC Genomics· November 2024

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Zinc finger nuclease-mediated gene editing in hematopoietic stem cells results in reactivation of fetal hemoglobin in sickle cell disease.
Samuel Lessard, Pauline Rimmelé, Hui Ling, Kevin Moran, Benjamin Vieira

Sci Rep· October 2024

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Genetic analyses of inflammatory polyneuropathy and chronic inflammatory demyelinating polyradiculoneuropathy identified candidate genes.
Zhaohui Du, Samuel Lessard, Tejaswi Iyyanki, Michael Chao, Timothy Hammond

HGG Adv· July 2024

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Genome-wide association study analysis of disease severity in Acne reveals novel biological insights.
Zhaohui Du, Tejaswi Iyyanki, Samuel Lessard, Michael Chao,

medRxiv· November 2023

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SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells.
Yannis Hara, Viktor T Lemgart, Nis Halland, Kiana Mahdaviani, Jean-Antoine Ribeil, Samuel Lessard

Blood Adv· June 2023

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Genome-Wide Association Study and Gene-Based Analysis of Participants With Hemophilia A and Inhibitors in the My Life, Our Future Research Repository.
Samuel Lessard, Chunla He, Deepak K Rajpal, Katherine Klinger, Christine Loh

Front Med (Lausanne)· June 2022

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A saturating mutagenesis CRISPR-Cas9-mediated functional genomic screen identifies and regulatory elements of in murine ESCs.
Matthew C Canver, Pratibha Tripathi, Michael J Bullen, Moshe Olshansky, Yogesh Kumar, Samuel Lessard

J Biol Chem· November 2020

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14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.
Samuel Lessard, Mélissa Beaudoin, Stuart H Orkin, Daniel E Bauer, Guillaume Lettre

Hum Mol Genet· April 2018

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Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.
Laura M Raffield, Jacob C Ulirsch, Rakhi P Naik, Samuel Lessard, Robert E Handsaker

PLoS Genet· March 2018

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Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.
Samuel Lessard, Laurent Francioli, Jessica Alfoldi, Jean-Claude Tardif, Patrick T Ellinor

Proc Natl Acad Sci U S A· December 2017

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Frameshift indels introduced by genome editing can lead to in-frame exon skipping.
Simon Lalonde, Oliver A Stone, Samuel Lessard, Adam Lavertu, Jessica Desjardins

PLoS One· September 2017

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An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.
Samuel Lessard, Emily Stern Gatof, Mélissa Beaudoin, Patrick G Schupp, Falak Sher

J Clin Invest· August 2017

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Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.
Matthew C Canver, Samuel Lessard, Luca Pinello, Yuxuan Wu, Yann Ilboudo

Nat Genet· April 2017

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Lower Methylation of the ANGPTL2 Gene in Leukocytes from Post-Acute Coronary Syndrome Patients.
Albert Nguyen, Maya Mamarbachi, Valérie Turcot, Samuel Lessard, Carol Yu

PLoS One· March 2017

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Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits.
Nathalie Chami, Ming-Huei Chen, Andrew J Slater, John D Eicher, Evangelos Evangelou, Samuel Lessard

Am J Hum Genet· July 2016

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Testing the role of predicted gene knockouts in human anthropometric trait variation.
Samuel Lessard, Alisa K Manning, Cécile Low-Kam, Paul L Auer, Ayush Giri

Hum Mol Genet· May 2016

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Comparison of DNA methylation profiles in human fetal and adult red blood cell progenitors.
Samuel Lessard, Mélissa Beaudoin, Karim Benkirane, Guillaume Lettre

Genome Med· January 2015

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An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.
Daniel E Bauer, Sophia C Kamran, Samuel Lessard, Jian Xu, Yuko Fujiwara

Science· October 2013

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