Publications by authors named "Sandra Castel"

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Validation and clinical application of an LC-MS/MS method designed to simultaneously measure seven second-line TB drugs and two metabolites in human lung tissue.
Katie Kriegler Foster, Anil Pooran, Marthinus van der Merwe, Sandra Castel, Anton Joubert

J Pharm Biomed Anal· December 2025

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Development and validation of a liquid chromatography-tandem mass spectrometry assay for the simultaneous analysis of isoniazid and pyrazinamide in cerebrospinal fluid.
Sydwell Poulo Maputla, Anton Joubert, Sandra Castel, Marthinus van der Merwe, Edda Zangenberg

J Pharm Biomed Anal· March 2025

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Development and validation of an LC-MS/MS method for quantifying total and unbound doravirine in human plasma.
Rizqah Bernard, Sydwell P Maputla, Phiwe Zuma, Anton Joubert, Sandra Castel

J Chromatogr B Analyt Technol Biomed Life Sci· February 2025

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Development and validation of an LC-MS/MS multiplex assay for the quantification of bedaquiline, n-desmethyl bedaquiline, linezolid, levofloxacin, and clofazimine in dried blood spots.
Gerard Aime Kenfack Teponnou, Anton Joubert, Saskia Spaltman, Marthinus van der Merwe, Edda Zangenberg, Sandra Castel

J Chromatogr B Analyt Technol Biomed Life Sci· February 2025

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Evaluation of pharmacokinetics of Tenofovir Alafenamide (TAF) and Tenofovir Disoproxil (TDF) in pregnant and postpartum women in South Africa: PrEP-PP PK study.
Dvora Joseph Davey, Sumaya Dadan, Kalisha Bheemraj, Catriona Waitt, Saye Khoo, Sandra Castel

Antiviral Res· November 2024

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Validation and application of an online extraction and liquid chromatography tandem mass spectrometry assay for the analysis of delamanid and its DM-6705 metabolite in human breast milk.
Buyisile Mkhize, Richard Court, Sandra Castel, Anton Joubert, Marthinus van der Merwe

J Pharm Biomed Anal· August 2024

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A validated liquid chromatography-tandem mass spectrometry assay for the analysis of isoniazid and its metabolite acetyl-isoniazid in urine.
Sydwell Poulo Maputla, Willem Van Dalen, Anton Joubert, Jennifer Norman, Sandra Castel

J Mass Spectrom Adv Clin Lab· April 2024

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Rifampicin and protein concentrations in paired spinal versus ventricular cerebrospinal fluid samples of children with tuberculous meningitis.
Jill Combrinck, Phophi Tshavhungwe, Ursula Rohlwink, Nico Enslin, Nqobile Thango, Sandra Castel

J Antimicrob Chemother· February 2024

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Development and validation of a liquid chromatography tandem mass spectrometry assay for the analysis of bedaquiline and M2 in breast milk.
Buyisile Mkhize, Richard Court, Sandra Castel, Anton Joubert, Marthinus van der Merwe

J Mass Spectrom Adv Clin Lab· January 2024

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Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis.
Marian Mazanhanga, Anton Joubert, Sandra Castel, Marthinus Van de Merwe, Gary Maartens

Heliyon· November 2023

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Liquid chromatography-tandem mass spectrometry analysis of delamanid and its metabolite in human cerebrospinal fluid using protein precipitation and on-line solid-phase extraction.
Marian T Mazanhanga, Anton Joubert, Sandra A Castel, Marthinus van der Merwe, Gary Maartens

J Pharm Biomed Anal· April 2023

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Population Pharmacokinetic Analysis of Rifampicin in Plasma, Cerebrospinal Fluid, and Brain Extracellular Fluid in South African Children with Tuberculous Meningitis.
Noha Abdelgawad, Mvuwo Phophi Tshavhungwe, Ursula Rohlwink, Helen McIlleron, Mahmoud T Abdelwahab, Sandra Castel

Antimicrob Agents Chemother· March 2023

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Validation of a quantitative multiplex LC-MS/MS assay of carvedilol, enalaprilat, and perindoprilat in dried blood spots from heart failure patients and its cross validation with a plasma assay.
Andre Joubert, Anton Joubert, Marthinus van der Merwe, Jennifer Norman, Sandra Castel

J Mass Spectrom Adv Clin Lab· January 2023

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Validation and application of a quantitative LC-MS/MS assay for the analysis of first-line anti-tuberculosis drugs, rifabutin and their metabolites in human breast milk.
Phiwe Zuma, Anton Joubert, Marthinus van der Merwe, Jennifer Norman, Catriona Waitt, Sandra Castel

J Chromatogr B Analyt Technol Biomed Life Sci· November 2022

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Validation and application of a quantitative liquid chromatography tandem mass spectrometry assay for the analysis of rifapentine and 25-O-desacetyl rifapentine in human milk.
Buyisile Mkhize, Tracy Kellermann, Jennifer Norman, Sandra Castel, Anton Joubert

J Pharm Biomed Anal· June 2022

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Relationship between Plasma and Intracellular Concentrations of Bedaquiline and Its M2 Metabolite in South African Patients with Rifampin-Resistant Tuberculosis.
Precious Ngwalero, James C M Brust, Stijn W van Beek, Sean Wasserman, Gary Maartens, Sandra Castel

Antimicrob Agents Chemother· October 2021

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Correction to: Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria.
Thomas A Anyorigiya, Sandra Castel, Katya Mauf, Frank Atuguba, Bernhards Ogutu

Malar J· March 2021

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A validated liquid chromatography tandem mass spectrometry assay for the analysis of pretomanid in plasma samples from pulmonary tuberculosis patients.
Andisiwe Malo, Tracy Kellermann, Elisa H Ignatius, Kelly E Dooley, Rodney Dawson, Sandra Castel

J Pharm Biomed Anal· February 2021

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Pharmacokinetic profile of amodiaquine and its active metabolite desethylamodiaquine in Ghanaian patients with uncomplicated falciparum malaria.
Thomas A Anyorigiya, Sandra Castel, Katya Mauff, Frank Atuguba, Bernhards Ogutu

Malar J· January 2021

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The determination of capreomycin in human plasma by LC-MS/MS using ion-pairing chromatography and solid-phase extraction.
Blessings Thuboy, Tracy Kellermann, Sandra Castel, Jennifer Norman, Anton Joubert

Biomed Chromatogr· May 2018

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Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children.
Retsilisitsoe R Moholisa, Michael Schomaker, Louise Kuhn, Sandra Castel, Lubbe Wiesner

Pediatr Infect Dis J· December 2016

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Pharmacokinetics of Isoniazid, Pyrazinamide, and Ethambutol in Newly Diagnosed Pulmonary TB Patients in Tanzania.
Paolo Denti, Kidola Jeremiah, Emmanuel Chigutsa, Daniel Faurholt-Jepsen, George PrayGod, Sandra Castel

PLoS One· June 2016

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Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.
Bafokeng Mpeta, Elizabeth Kampira, Sandra Castel, Keleabetswe L Mpye, Nyarai D Soko

Pharmacogenomics· May 2016

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An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.
Marelize Swart, Jonathan Evans, Michelle Skelton, Sandra Castel, Lubbe Wiesner

Front Genet· January 2016

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Population Pharmacokinetics of Rifampin in Pregnant Women with Tuberculosis and HIV Coinfection in Soweto, South Africa.
Paolo Denti, Neil Martinson, Silvia Cohn, Fildah Mashabela, Jennifer Hoffmann, Sandra Castel

Antimicrob Agents Chemother· December 2015

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