Publications by authors named "Sandra Minotti"

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Iridium-Bismuth-Oxide Coatings for Use in Neural Stimulating Electrodes: The Influence of Ir/Bi Ratio.
Xingge Xu, Irshad Ali, Sandra Minotti, Heather D Durham, Sasha Omanovic

J Biomed Mater Res A· July 2025

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Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Célia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Mario Fernandez Comaduran, Sandra Minotti

Nat Commun· December 2024

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Localized synthesis of molecular chaperones sustains neuronal proteostasis.
Celia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Mario Fernandez-Comaduran, Sandra Minotti

bioRxiv· October 2024

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Reversal of cognitive deficits in FUS amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.
Mari Carmen Pelaez, Frédéric Fiore, Nancy Larochelle, Afrooz Dabbaghizadeh, Mario Fernández Comaduran, Sandra Minotti

Neurotherapeutics· September 2024

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Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
Mario Fernández Comaduran, Sandra Minotti, Suleima Jacob-Tomas, Javeria Rizwan, Nancy Larochelle

Cell Stress Chaperones· June 2024

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Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Maria Vera Ugalde, Célia Alecki, Javeria Rizwan, Phuong Le, Suleima Jacob-Tomas, Sandra Minotti

Res Sq· December 2023

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The J Domain of Sacsin Disrupts Intermediate Filament Assembly.
Afrooz Dabbaghizadeh, Alexandre Paré, Zacharie Cheng-Boivin, Robin Dagher, Sandra Minotti

Int J Mol Sci· December 2022

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Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Rachel Kuta, Nancy Larochelle, Mario Fernandez, Arun Pal, Sandra Minotti

Cell Stress Chaperones· January 2020

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Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics.
Benoit J Gentil, Gia-Thanh Lai, Marie Menade, Roxanne Larivière, Sandra Minotti

FASEB J· February 2019

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Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis.
Michael Tibshirani, Beibei Zhao, Benoit J Gentil, Sandra Minotti, Christine Marques

Hum Mol Genet· November 2017

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Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay.
Roxanne Larivière, Rébecca Gaudet, Benoit J Gentil, Martine Girard, Talita Cristiane Conte, Sandra Minotti

Hum Mol Genet· February 2015

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Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1.
Michael Tibshirani, Miranda L Tradewell, Katie R Mattina, Sandra Minotti, Wencheng Yang

Hum Mol Genet· February 2015

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A novel small molecule HSP90 inhibitor, NXD30001, differentially induces heat shock proteins in nervous tissue in culture and in vivo.
Jieun R C Cha, Kyle J H St Louis, Miranda L Tradewell, Benoit J Gentil, Sandra Minotti

Cell Stress Chaperones· May 2014

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Expression of the protein chaperone, clusterin, in spinal cord cells constitutively and following cellular stress, and upregulation by treatment with Hsp90 inhibitor.
Samantha Zinkie, Benoit J Gentil, Sandra Minotti, Heather D Durham

Cell Stress Chaperones· November 2013

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Normal role of the low-molecular-weight neurofilament protein in mitochondrial dynamics and disruption in Charcot-Marie-Tooth disease.
Benoit J Gentil, Sandra Minotti, Madeleine Beange, Robert H Baloh, Jean-Pierre Julien

FASEB J· March 2012

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Calcium dysregulation, mitochondrial pathology and protein aggregation in a culture model of amyotrophic lateral sclerosis: mechanistic relationship and differential sensitivity to intervention.
Miranda L Tradewell, Laura A Cooper, Sandra Minotti, Heather D Durham

Neurobiol Dis· June 2011

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Progranulin is expressed within motor neurons and promotes neuronal cell survival.
Cara L Ryan, David C Baranowski, Babykumari P Chitramuthu, Suneil Malik, Zhi Li, Sandra Minotti

BMC Neurosci· October 2009

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Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.
Edor Kabashi, Jeffrey N Agar, Yu Hong, David M Taylor, Sandra Minotti

J Neurochem· June 2008

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Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.
David M Taylor, Miranda L Tradewell, Sandra Minotti, Heather D Durham

Cell Stress Chaperones· August 2007

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Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis.
David M Taylor, Bernard F Gibbs, Edor Kabashi, Sandra Minotti, Heather D Durham

J Biol Chem· June 2007

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Optimized protocols for isolation of primary motor neurons, astrocytes and microglia from embryonic mouse spinal cord.
Marie Gingras, Vicky Gagnon, Sandra Minotti, Heather D Durham, François Berthod

J Neurosci Methods· June 2007

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Manipulation of protein kinases reveals different mechanisms for upregulation of heat shock proteins in motor neurons and non-neuronal cells.
David M Taylor, Paul De Koninck, Sandra Minotti, Heather D Durham

Mol Cell Neurosci· January 2007

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Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis.
Zarah Batulan, David M Taylor, Rebecca J Aarons, Sandra Minotti, Mohammad M Doroudchi

Neurobiol Dis· November 2006

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Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts.
David M Taylor, Edor Kabashi, Jeffrey N Agar, Sandra Minotti, Heather D Durham

Cell Stress Chaperones· October 2005

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Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity.
David M Taylor, Sandra Minotti, Jeffrey N Agar, Heather D Durham

Neurotoxicology· September 2004

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