Publications by authors named "Sara E Howden"

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A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.
Sara E Howden, Bradley McColl, Astrid Glaser, Jim Vadolas, Steven Petrou, Melissa H Little, Andrew G Elefanty, Edouard G Stanley

Stem Cell Reports· September 2016

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Efficient Installation of Heterozygous Mutations in Human Pluripotent Stem Cells Using Prime Editing.
Annabelle Suter, Alison Graham, Jia Yi Kuah, Jason Crisologo, Chathuni Gunatilake, Sara E Howden

CRISPR J· December 2025

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Maturation of human cardiac organoids enables complex disease modeling and drug discovery.
Mark W Pocock, Janice D Reid, Harley R Robinson, Natalie Charitakis, James R Krycer, Sara E Howden

Nat Cardiovasc Res· July 2025

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Generation of an iPSC line (with isogenic control) from the PBMCs of a COL6A1 (c.1056 + 2T > A) Bethlem myopathy patient.
Vanessa G Crossman, Chrystal F Tiong, Chantal A Coles, Kiymet Bozaoglu, Robin Forbes, Sara E Howden

Stem Cell Res· April 2025

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A genetically inducible endothelial niche enables vascularization of human kidney organoids with multilineage maturation and emergence of renin expressing cells.
Joseph C Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Sara E Howden

Kidney Int· December 2024

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Generation of heterozygous (MCRIi031-A-1) and homozygous (MCRIi031-A-2) SOX9 knockout human iPSC lines.
Svenja Pachernegg, Gorjana Robevska, Lucas G A Ferreira, Jocelyn A van den Bergen, Katerina Vlahos, Sara E Howden

Stem Cell Res· September 2024

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Generation of a homozygous (MCRIi031-A-3) WT1 knockout human iPSC line.
Svenja Pachernegg, Gorjana Robevska, Lucas G A Ferreira, Jocelyn A van den Bergen, Katerina Vlahos, Sara E Howden

Stem Cell Res· September 2024

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Generation of heterozygous (MCRIi030-A-1) and homozygous (MCRIi030-A-2) NR2F2/COUP-TFII knockout human iPSC lines.
Lucas G A Ferreira, Mauricio C Cabral-da-Silva, Svenja Pachernegg, Jocelyn A van den Bergen, Gorjana Robevska, Sara E Howden

Stem Cell Res· April 2024

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Generation of a human ACTA1-tdTomato reporter iPSC line using CRISPR/Cas9 editing.
Peter J Houweling, Vanessa Crossman, Chrystal F Tiong, Chantal A Coles, Rhonda L Taylor, Sara E Howden

Stem Cell Res· March 2024

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Generation of iPSC lines from peripheral blood mononuclear cells from five healthy donors.
Katerina Vlahos, Koula Sourris, Jia Yi Kuah, Alison Graham, Annabelle Suter, Sara E Howden

Stem Cell Res· June 2023

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Genetically engineering endothelial niche in human kidney organoids enables multilineage maturation, vascularization and de novo cell types.
Joseph C Maggiore, Ryan LeGraw, Aneta Przepiorski, Jeremy Velazquez, Christopher Chaney, Sara E Howden

bioRxiv· May 2023

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Kidney Organoids Generated Using an Allelic Series of NPHS2 Point Variants Reveal Distinct Intracellular Podocin Mistrafficking.
Aude Dorison, Irene Ghobrial, Alison Graham, Thanushi Peiris, Thomas A Forbes, Sara E Howden

J Am Soc Nephrol· January 2023

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Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan, Ella Groenewegen, Rajeev Rudraraju, Sara E Howden

Nat Commun· October 2022

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Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids.
Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan, Ella Groenewegen, Rajeev Rudraraju, Sara E Howden

bioRxiv· May 2022

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DevKidCC allows for robust classification and direct comparisons of kidney organoid datasets.
Sean B Wilson, Sara E Howden, Jessica M Vanslambrouck, Aude Dorison, Jose Alquicira-Hernandez

Genome Med· February 2022

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Determining lineage relationships in kidney development and disease.
Melissa H Little, Sara E Howden, Kynan T Lawlor, Jessica M Vanslambrouck

Nat Rev Nephrol· January 2022

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Forward steps in organoid-based forward screening.
Melissa H Little, Sara E Howden

Cell Stem Cell· January 2022

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In vivo survival and differentiation of Friedreich ataxia iPSC-derived sensory neurons transplanted in the adult dorsal root ganglia.
Serena Viventi, Stefano Frausin, Sara E Howden, Shiang Y Lim, Rocio K Finol-Urdaneta

Stem Cells Transl Med· August 2021

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Generating an iPSC line (with isogenic control) from the PBMCs of an ACTA1 (p.Gly148Asp) nemaline myopathy patient.
Peter J Houweling, Chantal A Coles, Chrystal F Tiong, Bridget Nielsen, Alison Graham, Sara E Howden

Stem Cell Res· July 2021

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Plasticity of distal nephron epithelia from human kidney organoids enables the induction of ureteric tip and stalk.
Sara E Howden, Sean B Wilson, Ella Groenewegen, Lakshi Starks, Thomas A Forbes

Cell Stem Cell· April 2021

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Generating Kidney Organoids from Human Pluripotent Stem Cells Using Defined Conditions.
Sara E Howden, Melissa H Little

Methods Mol Biol· March 2021

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Cellular extrusion bioprinting improves kidney organoid reproducibility and conformation.
Kynan T Lawlor, Jessica M Vanslambrouck, J William Higgins, Alison Chambon, Kristina Bishard, Sara E Howden

Nat Mater· February 2021

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Recessive variants impair actin remodeling and cause glomerulopathy in humans and mice.
Amar J Majmundar, Florian Buerger, Thomas A Forbes, Verena Klämbt, Ronen Schneider, Sara E Howden

Sci Adv· January 2021

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Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia.
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E Howden, Simon Maksour, Amy E Hulme

Biomater Sci· May 2020

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A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids.
Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan, Joanne Y-C Soo, Michelle Scurr, Sara E Howden

J Am Soc Nephrol· October 2019

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Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.
Adam E Dolan, Zhonggang Hou, Yibei Xiao, Max J Gramelspacher, Jaewon Heo, Sara E Howden

Mol Cell· June 2019

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