Publications by authors named "Sarah C Shuck"

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Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate Cancer.
Alana Battad, Francisco Nunez, Mya S Walker, Sydney Hodge, Kelani Sun, Sarah C Shuck

bioRxiv· December 2025

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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes.
Edwin De Jesus Lopez Gonzalez, Swt Lai, Kelani Sun, Caree R Carson, Carlos Hernandez-Castillo, Sarah C Shuck

Mol Metab· August 2025

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Lack of mismatch repair enhances resistance to methylating agents for cells deficient in oxidative demethylation.
Roberto Gutierrez, Annie Yin S Chan, Seigmund Wai Tsuen Lai, Shunsuke Itoh, Dong-Hyun Lee, Sarah C Shuck

J Biol Chem· August 2024

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Methylglyoxal Adducts Are Prognostic Biomarkers for Diabetic Kidney Disease in Patients With Type 1 Diabetes.
Seigmund Wai Tsuen Lai, Carlos Hernandez-Castillo, Edwin De Jesus Lopez Gonzalez, Tala Zoukari, Min Talley, Sarah C Shuck

Diabetes· April 2024

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Methylglyoxal-Derived Nucleoside Adducts Drive Vascular Dysfunction in a RAGE-Dependent Manner.
Seigmund Wai Tsuen Lai, Supriyo Bhattacharya, Edwin De Jesus Lopez Gonzalez, Sarah C Shuck

Antioxidants (Basel)· January 2024

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Extracellular vesicles: A dive into their role in the tumor microenvironment and cancer progression.
Kassandra Lopez, Seigmund Wai Tsuen Lai, Edwin De Jesus Lopez Gonzalez, Raúl G Dávila, Sarah C Shuck

Front Cell Dev Biol· March 2023

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Methylglyoxal products in pre-symptomatic type 1 diabetes.
Sarah C Shuck, Peter Achenbach, Bart O Roep, John S Termini, Carlos Hernandez-Castillo

Front Endocrinol (Lausanne)· February 2023

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Methylglyoxal and Its Adducts: Induction, Repair, and Association with Disease.
Seigmund Wai Tsuen Lai, Edwin De Jesus Lopez Gonzalez, Tala Zoukari, Priscilla Ki, Sarah C Shuck

Chem Res Toxicol· October 2022

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DJ-1 is not a deglycase and makes a modest contribution to cellular defense against methylglyoxal damage in neurons.
Melissa Conti Mazza, Sarah C Shuck, Jiusheng Lin, Michael A Moxley, John Termini

J Neurochem· August 2022

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Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis.
Eryun Zhang, Lihua Jin, Yangmeng Wang, Jui Tu, Ruirong Zheng, Sarah C Shuck

Nat Commun· March 2022

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Diet and Obesity-Induced Methylglyoxal Production and Links to Metabolic Disease.
Carlos Hernandez-Castillo, Sarah C Shuck

Chem Res Toxicol· December 2021

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Elevated glucose increases genomic instability by inhibiting nucleotide excision repair.
Alexandra K Ciminera, Sarah C Shuck, John Termini

Life Sci Alliance· October 2021

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Metal-Assisted Protein Quantitation (MAPq): Multiplex Analysis of Protein Expression Using Lanthanide-Modified Antibodies with Detection by Inductively Coupled Plasma Mass Spectrometry.
Sarah C Shuck, Cu Nguyen, Yin Chan, Timothy O'Connor, Alexandra K Ciminera

Anal Chem· June 2020

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MLS128 antibody-induced suppression of colon cancer cell growth is mediated by a desmocollin and a 110 kDa glycoprotein.
Sarah C Shuck, Teresa Hong, Markus Kalkum, Ryo Igarashi, Kota Kajiya

Biosci Trends· July 2019

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Product Studies and Mechanistic Analysis of the Reaction of Methylglyoxal with Deoxyguanosine.
Sarah C Shuck, Gerald E Wuenschell, John S Termini

Chem Res Toxicol· February 2018

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Inhibition of GLO1 in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models.
Rahul Jandial, Josh Neman, Punnajit P Lim, Daniel Tamae, Claudia M Kowolik, Sarah C Shuck

Int J Mol Sci· January 2018

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DNA Advanced Glycation End Products (DNA-AGEs) Are Elevated in Urine and Tissue in an Animal Model of Type 2 Diabetes.
Richard Jaramillo, Sarah C Shuck, Yin S Chan, Xueli Liu, Steven E Bates

Chem Res Toxicol· February 2017

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Protein modification by adenine propenal.
Sarah C Shuck, Orrette R Wauchope, Kristie L Rose, Philip J Kingsley, Carol A Rouzer

Chem Res Toxicol· October 2014

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Mass spectrometric methods for the analysis of nucleoside-protein cross-links: application to oxopropenyl-deoxyadenosine.
Sarah C Shuck, Kristie L Rose, Lawrence J Marnett

Chem Res Toxicol· January 2014

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Replication, repair, and translesion polymerase bypass of N⁶-oxopropenyl-2'-deoxyadenosine.
Leena Maddukuri, Sarah C Shuck, Robert L Eoff, Linlin Zhao, Carmelo J Rizzo

Biochemistry· December 2013

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Selection of monoclonal antibodies against 6-oxo-M(1)dG and their use in an LC-MS/MS assay for the presence of 6-oxo-M(1)dG in vivo.
Dapo Akingbade, Philip J Kingsley, Sarah C Shuck, Tracy Cooper, Robert Carnahan

Chem Res Toxicol· February 2012

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Targeting the OB-Folds of Replication Protein A with Small Molecules.
Victor J Anciano Granadillo, Jennifer N Earley, Sarah C Shuck, Millie M Georgiadis, Richard W Fitch

J Nucleic Acids· December 2010

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Identification of novel small molecule inhibitors of the XPA protein using in silico based screening.
Tracy M Neher, Sarah C Shuck, Jing-Yuan Liu, Jian-Ting Zhang, John J Turchi

ACS Chem Biol· October 2010

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Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function.
Sarah C Shuck, John J Turchi

Cancer Res· April 2010

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Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology.
Sarah C Shuck, Emily A Short, John J Turchi

Cell Res· January 2008

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