Publications by authors named "Sarah Huntwork-Rodriguez"

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LRRK2 as a Potential Disease-Modifying Target in Sporadic Parkinson's Disease.
Anthony E Lang, Robert A Hauser, Lorraine V Kalia, Bonnie Hersh, Zdenek Berger, Sarah Huntwork-Rodriguez

Mov Disord· December 2025

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LRRK2 kinase activity regulates Parkinson's disease-relevant lipids at the lysosome.
Michael T Maloney, Xiang Wang, Rajarshi Ghosh, Shan V Andrews, Romeo Maciuca, Sarah Huntwork-Rodriguez

Mol Neurodegener· August 2025

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A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Maurits F J M Vissers, Matthew D Troyer, Eva Thijssen, Diana R Pereira, Jules A A C Heuberger, Sarah Huntwork-Rodriguez

Clin Transl Sci· August 2023

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LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Danna Jennings, Sarah Huntwork-Rodriguez, Maurits F J M Vissers, Vinay M Daryani, Dolores Diaz

Mov Disord· March 2023

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Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Danna Jennings, Sarah Huntwork-Rodriguez, Anastasia G Henry, Jennifer C Sasaki, René Meisner

Sci Transl Med· June 2022

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Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Xiang Wang, Elvira Negrou, Michael T Maloney, Vitaliy V Bondar, Shan V Andrews, Sarah Huntwork-Rodriguez

Sci Rep· June 2021

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Association of caffeine and related analytes with resistance to Parkinson disease among mutation carriers: A metabolomic study.
Grace F Crotty, Romeo Maciuca, Eric A Macklin, Junhua Wang, Manuel Montalban, Sarah Huntwork-Rodriguez

Neurology· December 2020

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The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Hardy J Rideout, Marie-Christine Chartier-Harlin, Matthew J Fell, Warren D Hirst, Sarah Huntwork-Rodriguez

Front Neurosci· August 2020

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The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.
Martin Larhammar, Sarah Huntwork-Rodriguez, York Rudhard, Arundhati Sengupta-Ghosh, Joseph W Lewcock

J Neurosci· November 2017

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Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.
Martin Larhammar, Sarah Huntwork-Rodriguez, Zhiyu Jiang, Hilda Solanoy, Arundhati Sengupta Ghosh

Elife· April 2017

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Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase.
Olav Olsen, Dara Y Kallop, Todd McLaughlin, Sarah Huntwork-Rodriguez, Zhuhao Wu

J Neurosci· May 2014

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JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.
Sarah Huntwork-Rodriguez, Bei Wang, Trent Watkins, Arundhati Sengupta Ghosh, Christine D Pozniak

J Cell Biol· September 2013

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DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
Trent A Watkins, Bei Wang, Sarah Huntwork-Rodriguez, Jing Yang, Zhiyu Jiang

Proc Natl Acad Sci U S A· March 2013

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Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.
Lauren K Buhl, Ramon A Jorquera, Yulia Akbergenova, Sarah Huntwork-Rodriguez, Dina Volfson

Mol Cell Neurosci· January 2013

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Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.
Ramon A Jorquera, Sarah Huntwork-Rodriguez, Yulia Akbergenova, Richard W Cho, J Troy Littleton

J Neurosci· December 2012

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