Publications by authors named "Sarah Needham"

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Tuneable gelatin methacryloyl (GelMA) hydrogels for the directed specification of renal cell types for hiPSC-derived kidney organoid maturation.
Shane Clerkin, Krutika Singh, Jessica L Davis, Niall J Treacy, Ivan Krupa, Sarah R Needham

Biomaterials· November 2025

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Profiling Protein Citrullination in Extracellular Vesicles by Single-Molecule Detection Using Direct Stochastic Optical Reconstruction Microscopy.
Sarah R Needham, Benjamin M Davis, Pinar Uysal-Onganer, Daniel J Rolfe, Mariya Hristova

J Biophotonics· November 2025

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Urinary Extracellular Vesicle Signatures as Biomarkers in Prostate Cancer Patients.
Sigrun Lange, Darryl Ethan Bernstein, Nikolay Dimov, Srinivasu Puttaswamy, Ian Johnston, Sarah R Needham

Int J Mol Sci· July 2025

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Microvascular aberrations found in human polycystic kidneys are an early feature in a Pkd1 mutant mouse model.
Daniyal J Jafree, Charith Perera, Mary Ball, Daniele Tolomeo, Gideon Pomeranz, Sarah Needham

Dis Model Mech· April 2025

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The use of NADH anisotropy to investigate mitochondrial cristae alignment.
Holly E Smith, Alasdair M Mackenzie, Chloe Seddon, Rhys Mould, Ifi Kalampouka, Sarah R Needham

Sci Rep· March 2024

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Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers.
R Sumanth Iyer, Sarah R Needham, Ioannis Galdadas, Benjamin M Davis, Selene K Roberts

Nat Commun· March 2024

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Ultra-Small Air-Stable Triplet-Triplet Annihilation Upconversion Nanoparticles for Anti-Stokes Time-Resolved Imaging.
Bolong Zhang, Kieran D Richards, Beatrice E Jones, Abigail R Collins, Rosie Sanders, Sarah R Needham

Angew Chem Int Ed Engl· November 2023

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Fluorescence and phosphorescence lifetime imaging reveals a significant cell nuclear viscosity and refractive index changes upon DNA damage.
Ellen Clancy, Siva Ramadurai, Sarah R Needham, Karen Baker, Tara A Eastwood

Sci Rep· January 2023

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Directly imaging the localisation and photosensitization properties of the pan-mTOR inhibitor, AZD2014, in living cancer cells.
Abdullah R Ahmed, Alessia Candeo, Sofia D'Abrantes, Sarah R Needham, Rahul B Yadav

J Photochem Photobiol B· December 2020

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Solid immersion microscopy images cells under cryogenic conditions with 12 nm resolution.
Lin Wang, Benji Bateman, Laura C Zanetti-Domingues, Amy N Moores, Sam Astbury, Sarah R Needham

Commun Biol· April 2020

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Super-resolution Microscopy at Cryogenic Temperatures Using Solid Immersion Lenses.
Benji C Bateman, Laura C Zanetti-Domingues, Amy N Moores, Sarah R Needham, Daniel J Rolfe

Bio Protoc· November 2019

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The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.
Laura C Zanetti-Domingues, Dimitrios Korovesis, Sarah R Needham, Christopher J Tynan, Shiori Sagawa

Nat Commun· October 2018

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Affimer proteins are versatile and renewable affinity reagents.
Christian Tiede, Robert Bedford, Sophie J Heseltine, Gina Smith, Imeshi Wijetunga, Sarah R Needham

Elife· June 2017

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EGFR oligomerization organizes kinase-active dimers into competent signalling platforms.
Sarah R Needham, Selene K Roberts, Anton Arkhipov, Venkatesh P Mysore, Christopher J Tynan

Nat Commun· October 2016

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A tale of the epidermal growth factor receptor: The quest for structural resolution on cells.
Christopher J Tynan, Valentina Lo Schiavo, Laura Zanetti-Domingues, Sarah R Needham, Selene K Roberts

Methods· February 2016

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Nanometric molecular separation measurements by single molecule photobleaching.
Stephen E D Webb, Michael Hirsch, Sarah R Needham, Benjamin C Coles, Kathrin M Scherer

Methods· October 2015

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Determining the geometry of oligomers of the human epidermal growth factor family on cells with 7 nm resolution.
Laura C Zanetti-Domingues, Michael Hirsch, Christopher J Tynan, Daniel J Rolfe, Teodor V Boyadzhiev, Sarah R Needham

Prog Biophys Mol Biol· September 2015

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Determining the geometry of oligomers of the human epidermal growth factor family on cells with <10 nm resolution.
Sarah R Needham, Laura C Zanetti-Domingues, Kathrin M Scherer, Michael Hirsch, Daniel J Rolfe

Biochem Soc Trans· June 2015

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Structure-function relationships and supramolecular organization of the EGFR (epidermal growth factor receptor) on the cell surface.
Sarah R Needham, Laura C Zanetti-Domingues, Michael Hirsch, Daniel J Rolfe, Christopher J Tynan

Biochem Soc Trans· February 2014

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Measuring EGFR separations on cells with ~10 nm resolution via fluorophore localization imaging with photobleaching.
Sarah R Needham, Michael Hirsch, Daniel J Rolfe, David T Clarke, Laura C Zanetti-Domingues

PLoS One· November 2013

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A systematic investigation of differential effects of cell culture substrates on the extent of artifacts in single-molecule tracking.
Laura C Zanetti-Domingues, Marisa L Martin-Fernandez, Sarah R Needham, Daniel J Rolfe, David T Clarke

PLoS One· May 2013

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Automated multidimensional single molecule fluorescence microscopy feature detection and tracking.
Daniel J Rolfe, Charles I McLachlan, Michael Hirsch, Sarah R Needham, Christopher J Tynan

Eur Biophys J· October 2011

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Optics clustered to output unique solutions: a multi-laser facility for combined single molecule and ensemble microscopy.
David T Clarke, Stanley W Botchway, Benjamin C Coles, Sarah R Needham, Selene K Roberts

Rev Sci Instrum· September 2011

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Effectiveness of a hypertension care management program provided by clinical pharmacists for veterans.
Susan D Bex, Amy S Boldt, Sarah B Needham, Stacy M Bolf, Cassandra M Walston

Pharmacotherapy· January 2011

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