Publications by authors named "Sascha Roth"

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Leveraging Targeted Protein Degradation for G Protein-Coupled Receptors: The Development of CCR2 Molecular Degraders.
Khaled Essa, Natalia V Ortiz Zacarías, Sascha Roth, Bo-Tao Xin, Sabine de Winter

J Med Chem· December 2025

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Orthogonal validation of PROTAC mediated degradation of the integral membrane proteins EGFR and c-MET.
Camilla Ruffilli, Sascha Röth, Noam Zelcer, Kevin Moreau

Sci Rep· January 2025

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Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2).
Natalia V Ortiz Zacarías, Sascha Röth, Jeremy D Broekhuis, Daan van der Es, Kevin Moreau

Int J Mol Sci· August 2024

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Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3.
Sascha Röth, Nur Mehpare Kocaturk, Preethi S Sathyamurthi, Bill Carton, Matthew Watt

Cell Chem Biol· October 2023

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Random forest microplastic classification using spectral subsamples of FT-IR hyperspectral images.
Jordi Valls-Conesa, Dominik J Winterauer, Niels Kröger-Lui, Sascha Roth, Fan Liu

Anal Methods· May 2023

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Harnessing nanobodies for target protein degradation through the Affinity-directed PROtein Missile (AdPROM) system.
Bill Carton, Sascha Röth, Thomas J Macartney, Gopal P Sapkota

Methods Enzymol· February 2023

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Proteolysis Targeting Chimeras (PROTACs): A Perspective on Integral Membrane Protein Degradation.
Camilla Ruffilli, Sascha Roth, Monica Rodrigo, Helen Boyd, Noam Zelcer

ACS Pharmacol Transl Sci· October 2022

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Novel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in vivo skin model.
Wibke Müller-Seubert, Sascha Roth, Theresa Hauck, Andreas Arkudas, Raymund E Horch

Int Wound J· December 2021

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Response to the letter to the editor 'Novel imaging methods reveal positive impact of topical negative pressure application on tissue perfusion in an in-vivo skin model'.
Wibke Müller-Seubert, Sascha Roth, Theresa Hauck, Andreas Arkudas, Raymund E Horch

Int Wound J· December 2021

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A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications.
Peter Stacey, Hannah Lithgow, Xiao Lewell, Agnieszka Konopacka, Stephen Besley

SLAS Discov· August 2021

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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System.
Sascha Röth, Thomas J Macartney, Agnieszka Konopacka, Kwok-Ho Chan, Houjiang Zhou

Cell Chem Biol· September 2020

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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System.
Luke M Simpson, Thomas J Macartney, Alice Nardin, Luke J Fulcher, Sascha Röth

Cell Chem Biol· September 2020

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Natural variation in HsfA2 pre-mRNA splicing is associated with changes in thermotolerance during tomato domestication.
Yangjie Hu, Anida Mesihovic, José M Jiménez-Gómez, Sascha Röth, Philipp Gebhardt

New Phytol· February 2020

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Advances in targeted degradation of endogenous proteins.
Sascha Röth, Luke J Fulcher, Gopal P Sapkota

Cell Mol Life Sci· July 2019

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DNA-binding and repressor function are prerequisites for the turnover of the tomato heat stress transcription factor HsfB1.
Sascha Röth, Oliver Mirus, Daniela Bublak, Klaus-Dieter Scharf, Enrico Schleiff

Plant J· January 2017

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Importance of organellar proteins, protein translocation and vesicle transport routes for pollen development and function.
Puneet Paul, Sascha Röth, Enrico Schleiff

Plant Reprod· June 2016

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Prospects of engineering thermotolerance in crops through modulation of heat stress transcription factor and heat shock protein networks.
Sotirios Fragkostefanakis, Sascha Röth, Enrico Schleiff, Klaus-Dieter Scharf

Plant Cell Environ· September 2015

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Hsp90 Is Involved in the Regulation of Cytosolic Precursor Protein Abundance in Tomato.
Bodo Tillmann, Sascha Röth, Daniela Bublak, Manuel Sommer, Ernst H K Stelzer

Mol Plant· July 2015

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Hsp90 is involved in the regulation of cytosolic precursor protein abundance in tomato.
Bodo Tillmann, Sascha Röth, Daniela Bublak, Manuel Sommer, Ernst H K Stelzer

Mol Plant· February 2015

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Hsp90 is involved in the regulation of cytosolic precursor protein abundance in tomato.
Bodo Tillmann, Sascha Röth, Daniela Bublak, Manuel Sommer, Ernst H K Stelzer

Mol Plant· October 2014

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