Publications by authors named "Saskia Scheij"

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Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.
Maartje W Rohaan, Troels H Borch, Joost H van den Berg, Özcan Met, Rob Kessels, Saskia Scheij

N Engl J Med· December 2022

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Regulation of intestinal LDLR by the LXR-IDOL axis.
Nienke M van Loon, Suzanne A E van Wouw, Roelof Ottenhoff, Jessica K Nelson, Jenina Kingma, Saskia Scheij

Atherosclerosis· December 2020

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Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.
Anke Loregger, Matthijs Raaben, Joppe Nieuwenhuis, Josephine M E Tan, Lucas T Jae, Saskia Scheij

Nat Commun· February 2020

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The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.
Daniela Herrera Moro Chao, Yanan Wang, Ewout Foppen, Roelof Ottenhoff, Cindy van Roomen, Saskia Scheij

Diabetes· December 2019

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HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.
Marc J Tol, Martijn J C van der Lienden, Tanit L Gabriel, Jacob J Hagen, Saskia Scheij

Autophagy· March 2019

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Differential use of E2 ubiquitin conjugating enzymes for regulated degradation of the rate-limiting enzymes HMGCR and SQLE in cholesterol biosynthesis.
Josephine M E Tan, Emma C L Cook, Marlene van den Berg, Saskia Scheij, Noam Zelcer

Atherosclerosis· February 2019

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Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice.
Nienke M van Loon, Roelof Ottenhoff, Sander Kooijman, Martina Moeton, Saskia Scheij

Arterioscler Thromb Vasc Biol· August 2018

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Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis.
Anke Loregger, Matthijs Raaben, Josephine Tan, Saskia Scheij, Martina Moeton

Arterioscler Thromb Vasc Biol· November 2017

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Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes.
Wouter W Kallemeijn, Saskia Scheij, Sascha Hoogendoorn, Martin D Witte, Daniela Herrera Moro Chao

PLoS One· August 2017

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Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene.
Emma C L Cook, Jessica K Nelson, Vincenzo Sorrentino, Duco Koenis, Martina Moeton, Saskia Scheij

PLoS One· August 2017

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Stabilization of Glucocerebrosidase by Active Site Occupancy.
Fredj Ben Bdira, Wouter W Kallemeijn, Saskia V Oussoren, Saskia Scheij, Boris Bleijlevens

ACS Chem Biol· July 2017

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EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux.
Jessica Kristine Nelson, Duco Steven Koenis, Saskia Scheij, Emma Clare Laura Cook, Martina Moeton

Arterioscler Thromb Vasc Biol· March 2017

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A Specific Activity-Based Probe to Monitor Family GH59 Galactosylceramidase, the Enzyme Deficient in Krabbe Disease.
André R A Marques, Lianne I Willems, Daniela Herrera Moro, Bogdan I Florea, Saskia Scheij

Chembiochem· February 2017

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A PPARγ-Bnip3 Axis Couples Adipose Mitochondrial Fusion-Fission Balance to Systemic Insulin Sensitivity.
Marc J Tol, Roelof Ottenhoff, Marco van Eijk, Noam Zelcer, Jan Aten, Saskia Scheij

Diabetes· September 2016

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Endo-β-Glucosidase Tag Allows Dual Detection of Fusion Proteins by Fluorescent Mechanism-Based Probes and Activity Measurement.
Wouter W Kallemeijn, Saskia Scheij, Tineke M Voorn-Brouwer, Martin D Witte, Marri Verhoek

Chembiochem· September 2016

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Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular β-glucosidases.
André R A Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J Ferraz, Saskia Scheij

J Lipid Res· March 2016

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Lysosomal glycosphingolipid catabolism by acid ceramidase: formation of glycosphingoid bases during deficiency of glycosidases.
Maria J Ferraz, André R A Marques, Monique D Appelman, Marri Verhoek, Anneke Strijland, Saskia Scheij

FEBS Lett· March 2016

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Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
Jessica Kristine Nelson, Emma Clare Laura Cook, Anke Loregger, Marten Anne Hoeksema, Saskia Scheij

J Biol Chem· February 2016

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Identification of the (Pro)renin Receptor as a Novel Regulator of Low-Density Lipoprotein Metabolism.
Xifeng Lu, Marcel E Meima, Jessica K Nelson, Vincenzo Sorrentino, Anke Loregger, Saskia Scheij

Circ Res· January 2016

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and comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases.
Jianbing Jiang, Wouter W Kallemeijn, Daniel W Wright, Adrianus M C H van den Nieuwendijk, Veronica Coco Rohde, Saskia Scheij

Chem Sci· May 2015

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LIM-only protein FHL2 is a positive regulator of liver X receptors in smooth muscle cells involved in lipid homeostasis.
Kondababu Kurakula, Daniela Sommer, Milka Sokolovic, Perry D Moerland, Saskia Scheij

Mol Cell Biol· January 2015

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Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates.
Boudewijn A Duivenvoorden, Karen Ghauharali, Saskia Scheij, Rolf G Boot, Johannes M F G Aerts

Carbohydr Res· November 2014

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Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors.
Amar T Ghisaidoobe, Richard J B H N van den Berg, Saleem S Butt, Anneke Strijland, Wilma E Donker-Koopman, Saskia Scheij

J Med Chem· November 2014

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Potent and selective activity-based probes for GH27 human retaining α-galactosidases.
Lianne I Willems, Thomas J M Beenakker, Benjamin Murray, Saskia Scheij, Wouter W Kallemeijn

J Am Chem Soc· August 2014

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Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis.
Paulo Gaspar, Wouter W Kallemeijn, Anneke Strijland, Saskia Scheij, Marco Van Eijk

J Lipid Res· January 2014

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