Publications by authors named "Satoru Funamoto"

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γ-Secretase exosites as targets for substrate-selective lowering of Aβ generation.
Riki Maruyama, Akio Fukumori, Satoru Funamoto, Ken Okada, Shoshin Akamine

Structure· December 2025

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High Affinity Staining for Histological Immunoreactivity revealed phosphorylated tau within amyloid-cored plaques in the brain of AD model mice.
Yuto Higashi, Kanta Ikuno, Takashi Saito, Takaomi C Saido, Tomohiro Miyasaka, Satoru Funamoto

Biochem Biophys Res Commun· July 2025

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The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Rikuya Yoshimura, Tomohiro Miyasaka, Satoru Funamoto, Takashi Saito, Takaomi C Saido

Brain Behav· April 2023

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A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.
Waka Sato, Miho Watanabe-Takahashi, Takuya Murata, Naoko Utsunomiya-Tate, Jun Motoyama, Satoru Funamoto

Commun Biol· April 2023

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A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit.
Waka Sato, Miho Watanabe-Takahashi, Takashi Hamabata, Koichi Furukawa, Satoru Funamoto

Biochem Biophys Res Commun· June 2021

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A potential defense mechanism against amyloid deposition in cerebellum.
Alam Shahnur, Masaki Nakano, Seiko Ishihara, Nobuto Kakuda, Tomohiro Miyasaka, Satoru Funamoto

Biochem Biophys Res Commun· January 2021

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Successive cleavage of β-amyloid precursor protein by γ-secretase.
Satoru Funamoto, Shinji Tagami, Masayasu Okochi, Maho Morishima-Kawashima

Semin Cell Dev Biol· September 2020

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γ-Secretase Activity Is Associated with Braak Senile Plaque Stages.
Nobuto Kakuda, Haruyasu Yamaguchi, Kohei Akazawa, Saori Hata, Toshiharu Suzuki, Satoru Funamoto

Am J Pathol· June 2020

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Curcumin Derivative GT863 Inhibits Amyloid-Beta Production via Inhibition of Protein N-Glycosylation.
Yasuomi Urano, Mina Takahachi, Ryo Higashiura, Hitomi Fujiwara, Satoru Funamoto

Cells· February 2020

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Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.
Mohammad Moniruzzaman, Seiko Ishihara, Mika Nobuhara, Hidekazu Higashide, Satoru Funamoto

Biochem Biophys Res Commun· July 2018

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Pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy.
Kentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, Satoru Funamoto, Yoshiro Saito

Genes Cells· January 2018

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Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.
Hidekazu Higashide, Seiko Ishihara, Mika Nobuhara, Yasuo Ihara, Satoru Funamoto

J Neurochem· March 2017

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Affinity-Based Screening of Tetravalent Peptides Identifies Subtype-Selective Neutralizers of Shiga Toxin 2d, a Highly Virulent Subtype, by Targeting a Unique Amino Acid Involved in Its Receptor Recognition.
Takaaki Mitsui, Miho Watanabe-Takahashi, Eiko Shimizu, Baihao Zhang, Satoru Funamoto

Infect Immun· September 2016

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The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.
Asuka Kokawa, Seiko Ishihara, Hitomi Fujiwara, Mika Nobuhara, Minori Iwata, Satoru Funamoto

Acta Neuropathol Commun· November 2015

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Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.
Satoru Funamoto, Toru Sasaki, Seiko Ishihara, Mika Nobuhara, Masaki Nakano

Nat Commun· May 2014

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γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment.
Nobutaka Matsumura, Mako Takami, Masayasu Okochi, Satoko Wada-Kakuda, Hitomi Fujiwara, Satoru Funamoto

J Biol Chem· February 2014

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Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3.
Min Suk Kang, Seung-Hoon Baek, Yoon Sun Chun, A Zenobia Moore, Natalie Landman, Satoru Funamoto

J Biol Chem· July 2013

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γ-Secretase-Dependent Proteolysis of Transmembrane Domain of Amyloid Precursor Protein: Successive Tri- and Tetrapeptide Release in Amyloid β-Protein Production.
Mako Takami, Satoru Funamoto

Int J Alzheimers Dis· January 2013

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Potent amyloidogenicity and pathogenicity of Aβ43.
Takashi Saito, Takahiro Suemoto, Nathalie Brouwers, Kristel Sleegers, Satoru Funamoto

Nat Neurosci· July 2011

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The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel.
Kohji Mori, Masayasu Okochi, Shinji Tagami, Taisuke Nakayama, Kanta Yanagida, Satoru Funamoto

Psychogeriatrics· September 2010

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gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
Mako Takami, Yu Nagashima, Yoshihisa Sano, Seiko Ishihara, Maho Morishima-Kawashima, Satoru Funamoto

J Neurosci· October 2009

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Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.
Satoko Osawa, Satoru Funamoto, Mika Nobuhara, Satoko Wada-Kakuda, Masafumi Shimojo

J Biol Chem· July 2008

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Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
Masafumi Shimojo, Naruhiko Sahara, Tatsuya Mizoroki, Satoru Funamoto, Maho Morishima-Kawashima

J Biol Chem· June 2008

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Active gamma-secretase complexes contain only one of each component.
Toru Sato, Thekla S Diehl, Saravanakumar Narayanan, Satoru Funamoto, Yasuo Ihara

J Biol Chem· November 2007

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Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
Nobuto Kakuda, Satoru Funamoto, Sousuke Yagishita, Mako Takami, Satoko Osawa

J Biol Chem· May 2006

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