Publications by authors named "Sayed Shehata"

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Amelioration of intestinal ischemia reperfusion injury by carvedilol via regulation of eNOS/VEGF-A and inflammasome/ IL1β/ TNFα pathways.
Marwa Monier Mahmoud Refaie, Elshymaa A Abdel-Hakeem, Sayed Shehata, Shereen Mohammed Mohammed Elsaghir, Manar Fouli Gaber Ibrahim

Eur J Pharmacol· October 2025

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Role of sacubitril/valsartan in testicular ischaemia reperfusion injury via modulation of AngII/ASK/NF-κB and JAK/STAT pathways in juvenile rats.
Marwa Monier Mahmoud Refaie, Elshymaa A Abdel-Hakeem, Randa Ahmed Ibrahim, Zamzam Hassan Mohamed, Sayed Shehata

Br J Pharmacol· September 2025

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Immune regulation of TLR4/MYD88/ NF-κB/AP1/IL-6 pathway and modulation of aldosterone/PPARα receptors by eplerenone and fenofibrate in ovarian ischemia reperfusion induced injury.
Marwa Monier Mahmoud Refaie, Elshymaa A Abdel-Hakeem, Sayed Shehata, Shereen Mohammed Mohammed Elsaghir, Sahar Ahmed Mokhemer

Int Immunopharmacol· September 2025

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Amelioration of intestinal ischemia reperfusion injury by diacerein via regulation of inflammasome/caspase-1/IL-1β and Wnt/β-catenin pathways in juvenile rats.
Marwa Monier Mahmoud Refaie, Nada Amgad Mohamed Abdel Majeed, Sayed Shehata, Asmaa A Muhammed, Salma M Hassan

Naunyn Schmiedebergs Arch Pharmacol· September 2025

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Serum midkine level and its association with subclinical coronary artery calcification and carotid atherosclerosis in chronic kidney disease.
Osama Nady Mohamed, Marwa Ibrahim Mohamed, Shaimaa F Kamel, Ahmed M Dardeer, Sayed Shehata

BMC Nephrol· April 2025

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Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study.
Osama Nady Mohamed, Sharehan Abdelrahman Ibrahim, Shereen Mohammed Mohammed Elsaghir, Marwa Ibrahim Mohamed, Basma Fathy, Sayed Shehata

J Nephrol· March 2025

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Sacubitril/valsartan alleviates sepsis-induced myocardial injury in rats via dual angiotensin receptor-neprilysin inhibition and modulation of inflammasome/caspase 1/IL1β pathway.
Marwa Monier Mahmoud Refaie, Maram El-Hussieny, Asmaa M A Bayoumi, Wedad M Abdelraheem, Elshymaa A Abdel-Hakeem, Sayed Shehata

Eur J Pharmacol· September 2024

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Cardioprotective role of diacerein in diabetic cardiomyopathy via modulation of inflammasome/caspase1/interleukin1β pathway in juvenile rats.
Marwa M M Refaie, Hanaa Hassanein Mohammed, Elshymaa A Abdel-Hakeem, Asmaa M A Bayoumi, Zamzam Hassan Mohamed, Sayed Shehata

Naunyn Schmiedebergs Arch Pharmacol· July 2024

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Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats.
Marwa Monier Mahmoud Refaie, Sayed Shehata, Maram El-Hussieny, Michael Atef Fawzy, Nagwa Zenhom Mustafa Ahmed

Toxicol Res· January 2024

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Molecular mechanisms mediate roflumilast protective effect against isoprenaline-induced myocardial injury.
Marwa Monier Mahmoud Refaie, Manar Fouli Gaber Ibrahim, Michael Atef Fawzy, Elshymaa A Abdel-Hakeem, Eman Shaaban Mahmoud Abd El Rahman, Sayed Shehata

Immunopharmacol Immunotoxicol· December 2023

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Role of hypoxia inducible factor/vascular endothelial growth factor/endothelial nitric oxide synthase signaling pathway in mediating the cardioprotective effect of dapagliflozin in cyclophosphamide-induced cardiotoxicity.
Marwa Monier Mahmoud Refaie, Asmaa Ma Bayoumi, Sahar Ahmed Mokhemer, Sayed Shehata, Nahla Mohammed Abd El-Hameed

Hum Exp Toxicol· November 2023

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Exploring the role of ATP-sensitive potassium channel, eNOS, and P-glycoprotein in mediating the hepatoprotective activity of nicorandil in methotrexate-induced liver injury in rats.
Marwa M M Refaie, Maram El-Hussieny, Sayed Shehata, Nermeen N Welson, Walaa Yehia Abdelzaher

Immunopharmacol Immunotoxicol· October 2023

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Sacubitril/valsartan cardioprotective effect against cisplatin-induced cardiotoxicity via modulation of VEGF/eNOS and TLR4/TNFα/IL6 signalling pathways.
Marwa Monier Mahmoud Refaie, Rehab Ahmed Rifaai, Asmaa M A Bayoumi, Sayed Shehata

J Pharm Pharmacol· September 2023

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Retraction Note: Dapagliflozin Guards Against Cadmium-Induced Cardiotoxicity via Modulation of IL6/STAT3 and TLR2/TNFα Signaling Pathways.
Marwa M M Refaie, Rehab Ahmed Rifaai, Michael Atef Fawzy, Sayed Shehata

Cardiovasc Toxicol· April 2023

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Dapagliflozin Guards Against Cadmium-Induced Cardiotoxicity via Modulation of IL6/STAT3 and TLR2/TNFα Signaling Pathways.
Marwa M M Refaie, Rehab Ahmed Rifaai, Michael Atef Fawzy, Sayed Shehata

Cardiovasc Toxicol· November 2022

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The IL-6/STAT Signaling Pathway and PPARα Are Involved in Mediating the Dose-Dependent Cardioprotective Effects of Fenofibrate in 5-Fluorouracil-Induced Cardiotoxicity.
Marwa M M Refaie, Sayed Shehata, Asmaa M A Bayoumi, Nashwa Fathy Gamal El-Tahawy, Walaa Yehia Abdelzaher

Cardiovasc Drugs Ther· October 2022

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Phosphodiesterase inhibitor, Vinpocetine, guards against doxorubicin induced cardiotoxicity modulation of HIF/VEGF and cGMP/cAMP/SIRT signaling pathways.
Marwa M M Refaie, Maram El-Hussieny, Elshymaa A Abdel-Hakeem, Michael A Fawzy, Eman Shaaban Mahmoud Abd El Rahman, Sayed Shehata

Hum Exp Toxicol· October 2022

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TLR4/NF-κB/TNFα and cAMP/SIRT1 signaling cascade involved in mediating the dose-dependent effect of cilostazol in ovarian ischemia reperfusion-induced injury.
Marwa M M Refaie, Maram El-Hussieny, Sayed Shehata

Immunopharmacol Immunotoxicol· June 2022

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Simvastatin cardioprotection in cyclophosphamide-induced toxicity via the modulation of inflammasome/caspase1/interleukin1β pathway.
Marwa Mm Refaie, Maram El-Hussieny, Asmaa Ma Bayoumi, Sayed Shehata, Nermeen N Welson

Hum Exp Toxicol· June 2022

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Dose-Dependent Cardioprotective Effect of Hemin in Doxorubicin-Induced Cardiotoxicity Via Nrf-2/HO-1 and TLR-5/NF-κB/TNF-α Signaling Pathways.
Marwa M M Refaie, Sayed Shehata, Randa Ahmed Ibrahim, Asmaa M A Bayoumi, Seham A Abdel-Gaber

Cardiovasc Toxicol· December 2021

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Dose dependent effect of cilostazol in induced testicular ischemia reperfusion via modulation of HIF/VEGF and cAMP/SIRT1 pathways.
Marwa M M Refaie, Randa Ahmed Ibrahim, Sayed Shehata

Int Immunopharmacol· December 2021

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Cardioprotective effect of hemin in isoprenaline-induced myocardial infarction: role of ATP-sensitive potassium channel and endothelial nitric oxide synthase.
Marwa M M Refaie, Rehab A Rifaai, Asmaa M A Bayoumi, Sayed Shehata

Fundam Clin Pharmacol· June 2020

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Role of ATP-Sensitive Potassium Channel (K) and eNOS in Mediating the Protective Effect of Nicorandil in Cyclophosphamide-Induced Cardiotoxicity.
Marwa M M Refaie, Sayed Shehata, Maram El-Hussieny, Wedad M Abdelraheem, Asmaa M A Bayoumi

Cardiovasc Toxicol· February 2020

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Mechanisms mediating the cardioprotective effect of carvedilol in cadmium induced cardiotoxicity. Role of eNOS and HO1/Nrf2 pathway.
Marwa M M Refaie, Maram El-Hussieny, Asmaa M A Bayoumi, Sayed Shehata

Environ Toxicol Pharmacol· August 2019

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Clinical and procedural predictors of suboptimal myocardial reperfusion in primary percutaneous coronary intervention.
Adel H Mahmoud, Nasser M Taha, Khaled Baraka, Mohamed Ashraf, Sayed Shehata

Int J Cardiol Heart Vasc· June 2019

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