Publications by authors named "Scot C Leary"

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The 41BB-agonist potentiates the therapeutic efficacy of a combined irreversible electroporation ablation treatment of lung cancer by promoting unexpected CD8CD103 cDC1 and tissue-resident memory T cell responses.
Chen Fang, Zhaojia Wu, Scot C Leary, Yiling Bai, Michelle Yu

Front Immunol· November 2025

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CD40 agonist improves the therapeutic efficacy of irreversible electroporation ablation for metastatic melanoma by promoting unexpected CD8CD103 cDC1 and TRM cell responses.
Zhaojia Wu, Zhenyu Yang, Tauqeer Iftikhar, Gary Groot, Scot C Leary

Cancer Immunol Immunother· November 2025

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Heart is the most susceptible organ in an isogenic background to loss of function mutations in the mitochondrial metallochaperone SCO1.
Sampurna Ghosh, Kimberly A Jett, Zakery N Baker, Aren Boulet, Amzad Hossain, Scot C Leary

Hum Mol Genet· September 2025

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The DRP1 receptor FIS1 is critical to the expansion of triple-negative breast cancer tumor-initiating cells.
Tetiana Katrii, Tanya Freywald, Malkon G Estrada, Amr El Zawily, Behzad Toosi, Scot C Leary

Cancer Cell Int· July 2025

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Identification of targetable vulnerabilities of PLK1-overexpressing cancers by synthetic dosage lethality.
Chelsea E Cunningham, Frederick S Vizeacoumar, Yue Zhang, Liliia Kyrylenko, Simon Both, Scot C Leary

Cell Genom· June 2025

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Lymphopoiesis is attenuated upon hepatocyte-specific deletion of the cytochrome oxidase assembly factor .
KimAnh T Pioli, Sampurna Ghosh, Aren Boulet, Scot C Leary, Peter D Pioli

iScience· April 2025

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Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways.
Yiling Bai, Zhaojia Wu, Scot C Leary, Chen Fang, Michelle Yu

Int J Mol Sci· February 2025

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Molecular basis and pathways of the Yin-Yang theory in T cell immunity.
Jim Xiang, Scot C Leary, Zhaojia Wu, Michelle Yu

Front Immunol· November 2024

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Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models.
Kimberly A Jett, Zakery N Baker, Amzad Hossain, Aren Boulet, Paul A Cobine, Scot C Leary

J Clin Invest· January 2023

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The Critical Role of AMPKα1 in Regulating Autophagy and Mitochondrial Respiration in IL-15-Stimulated mTORC1 Signal-Induced T Cell Memory: An Interplay between Yin (AMPKα1) and Yang (mTORC1) Energy Sensors in T Cell Differentiation.
Anjuman Ara, Zhaojia Wu, Aizhang Xu, Khawaja Ashfaque Ahmed, Scot C Leary

Int J Mol Sci· August 2022

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Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
Aizhang Xu, Scot C Leary, Md Fahmid Islam, Zhaojia Wu, Kalpana Kalyanasundaram Bhanumathy

J Immunol· January 2022

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The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory.
Anjuman Ara, Aizhang Xu, Khawaja Ashfaque Ahmed, Scot C Leary, Md Fahmid Islam

Int J Mol Sci· December 2021

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Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival.
Christopher Lowden, Aren Boulet, Nicholas A Boehler, Shavanie Seecharran, Julian Rios Garcia, Scot C Leary

Cell Rep· September 2021

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Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes.
Xinyu Zhu, Aren Boulet, Katherine M Buckley, Casey B Phillips, Micah G Gammon, Scot C Leary

Elife· February 2021

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Getting out what you put in: Copper in mitochondria and its impacts on human disease.
Paul A Cobine, Stanley A Moore, Scot C Leary

Biochim Biophys Acta Mol Cell Res· January 2021

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The Aβ(1-38) peptide is a negative regulator of the Aβ(1-42) peptide implicated in Alzheimer disease progression.
Maa O Quartey, Jennifer N K Nyarko, Jason M Maley, Jocelyn R Barnes, Maria A C Bolanos, Scot C Leary

Sci Rep· January 2021

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Advances in visualization of copper in mammalian systems using X-ray fluorescence microscopy.
Scot C Leary, Martina Ralle

Curr Opin Chem Biol· April 2020

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COA6 Is Structurally Tuned to Function as a Thiol-Disulfide Oxidoreductase in Copper Delivery to Mitochondrial Cytochrome c Oxidase.
Shivatheja Soma, Marcos N Morgada, Mandar T Naik, Aren Boulet, Anna A Roesler, Scot C Leary

Cell Rep· December 2019

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Cellular Uptake and Distribution of Gemini Surfactant Nanoparticles Used as Gene Delivery Agents.
Wei Jin, Mays Al-Dulaymi, Ildiko Badea, Scot C Leary, Jeveria Rehman

AAPS J· August 2019

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The determination of gemini surfactants used as gene delivery agents in cellular matrix using validated tandem mass spectrometric method.
Wei Jin, Ildiko Badea, Scot C Leary, Anas El-Aneed

J Pharm Biomed Anal· February 2019

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Elesclomol restores mitochondrial function in genetic models of copper deficiency.
Shivatheja Soma, Andrew J Latimer, Haarin Chun, Alison C Vicary, Shrishiv A Timbalia, Scot C Leary

Proc Natl Acad Sci U S A· August 2018

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Building the Cu site of cytochrome oxidase: A complicated, redox-dependent process driven by a surprisingly large complement of accessory proteins.
Kimberly A Jett, Scot C Leary

J Biol Chem· March 2018

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The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome oxidase biogenesis.
Aren Boulet, Katherine E Vest, Margaret K Maynard, Micah G Gammon, Antoinette C Russell, Scot C Leary

J Biol Chem· February 2018

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The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart.
Zakery N Baker, Kimberly Jett, Aren Boulet, Amzad Hossain, Paul A Cobine, Scot C Leary

Hum Mol Genet· December 2017

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The mitochondrion: a central architect of copper homeostasis.
Zakery N Baker, Paul A Cobine, Scot C Leary

Metallomics· November 2017

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