Publications by authors named "Scott D Gray-Owen"

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Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine.
Natalie Y T Au, En Ze L Zhong, Jamie E Fegan, Epshita A Islam, Stacey X Xu, Scott D Gray-Owen

bioRxiv· November 2025

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Small molecule dysregulation of ClpP activity via bidirectional allosteric pathways.
Marim M Barghash, Mark F Mabanglo, Samuel E Hoff, Dmytro Brozdnychenko, Keith S Wong, Scott D Gray-Owen

Structure· October 2025

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Rationally designed minimized TbpB confers broad protection against meningococcal infection.
Epshita A Islam, Jamie E Fegan, Gregory B Cole, Charles Calmettes, Dixon Ng, Scott D Gray-Owen

bioRxiv· October 2025

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Bacterial ADP-heptose triggers stem cell regeneration in the intestinal epithelium following injury.
Shawn Goyal, Cynthia X Guo, Ojas Singh, Adrienne Ranger, Caitlin F Harrigan, Scott D Gray-Owen

Cell Stem Cell· August 2025

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Network-based population analysis of 31,595 gonococcal genomes reveals phase variability, genetic diversity and mobile element dynamics drive antimicrobial resistance and phenotypic diversity.
Duncan Carruthers-Lay, Jessica Lam, Emil Jurga, Scott D Gray-Owen, John Parkinson

bioRxiv· July 2025

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Meningococcal vaccine 4CMenB elicits a robust cellular immune response that targets but is not consistently protective against during murine vaginal infection.
Joseph J Zeppa, Jamie E Fegan, Pauline Maiello, Epshita A Islam, Isaac S Lee, Scott D Gray-Owen

mSphere· May 2025

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Adjuvant-dependent impacts on vaccine-induced humoral responses and protection in preclinical models of nasal and genital colonization by pathogenic Neisseria.
Epshita A Islam, Jamie E Fegan, Joseph J Zeppa, Sang Kyun Ahn, Dixon Ng, Scott D Gray-Owen

Vaccine· February 2025

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Pathogenesis and transmission of SARS-CoV-2 D614G, Alpha, Gamma, Delta, and Omicron variants in golden hamsters.
Andra Banete, Bryan D Griffin, Juan C Corredor, Emily Chien, Lily Yip, Scott D Gray-Owen

Npj Viruses· February 2025

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Rational selection of TbpB variants yields a bivalent vaccine with broad coverage against Neisseria gonorrhoeae.
Jamie E Fegan, Epshita A Islam, David M Curran, Dixon Ng, Natalie Y T Au, Scott D Gray-Owen

NPJ Vaccines· January 2025

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Targeting protein homeostasis with small molecules as a strategy for the development of pan-coronavirus antiviral therapies.
Yu-Qian Mao, Shahrzad Jahanshahi, Ramy Malty, David A J Van Ommen, Yimei Wan, Scott D Gray-Owen

Commun Biol· November 2024

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Structure-Based Design and Development of Phosphine Oxides as a Novel Chemotype for Antibiotics that Dysregulate Bacterial ClpP Proteases.
Funing Lin, Mark F Mabanglo, Jin Lin Zhou, Gursonika Binepal, Marim M Barghash, Scott D Gray-Owen

J Med Chem· September 2024

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Human transferrin and lactoferrin cooperatively support colonization in the murine nasopharynx.
Isaac S Lee, Jamie E Fegan, Elissa G Currie, Anna Bojagora, Nelly Y Leung, Scott D Gray-Owen

bioRxiv· September 2024

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Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against .
Jamie E Fegan, Epshita A Islam, David M Curran, Dixon Ng, Natalie Au, Scott D Gray-Owen

bioRxiv· September 2024

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Adjuvant-dependent impacts on vaccine-induced humoral responses and protection in preclinical models of nasal and genital colonization by pathogenic Neisseria.
Epshita A Islam, Jamie E Fegan, Joseph J Zeppa, Sang K Ahn, Dixon Ng, Scott D Gray-Owen

bioRxiv· September 2024

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Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection.
Joseph J Zeppa, Jamie E Fegan, Pauline Maiello, Epshita A Islam, Isaac S Lee, Scott D Gray-Owen

bioRxiv· September 2024

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High-dimensional mapping of human CEACAM1 expression on immune cells and association with melanoma drug resistance.
Yu-Hwa Huang, Charles H Yoon, Amit Gandhi, Thomas Hanley, Carlos Castrillon, Scott D Gray-Owen

Commun Med (Lond)· July 2024

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Developing a PmSLP3-based vaccine formulation that provides robust long-lasting protection against hemorrhagic septicemia-causing serogroup B and E strains of in cattle.
Jamie E Fegan, Regula C Waeckerlin, Liyuwork Tesfaw, Epshita A Islam, Getaw Deresse, Scott D Gray-Owen

Front Immunol· June 2024

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SARS-CoV-2 antibodies and their neutralizing capacity against live virus in human milk after COVID-19 infection and vaccination: prospective cohort studies.
Samantha Ismail, Sharon Unger, Patrick Budylowski, Susan Poutanen, Yvonne Yau, Scott D Gray-Owen

Am J Clin Nutr· February 2024

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Longitudinal Analysis of Mpox Virus DNA Detectability From Multiple Specimen Types During Acute Illness: A Cohort Study.
Darrell H S Tan, Oscar Pico Espinosa, John Matelski, Shreya S Khera, Attia Qamar, Scott D Gray-Owen

Open Forum Infect Dis· February 2024

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Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Hong Yu, Liam J Worrall, Thorsten Berger, Martin Petric, Bryan H Lin, Scott D Gray-Owen

J Immunol· September 2023

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Reverse vaccinology-based identification of a novel surface lipoprotein that is an effective vaccine antigen against bovine infections caused by Pasteurella multocida.
Epshita A Islam, Jamie E Fegan, Takele A Tefera, David M Curran, Regula C Waeckerlin, Scott D Gray-Owen

PLoS Pathog· March 2023

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Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors.
Katherine Chan, Adrian Granda Farias, Hunsang Lee, Furkan Guvenc, Patricia Mero, Scott D Gray-Owen

Heliyon· January 2023

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Correlated STORM-homoFRET imaging reveals highly heterogeneous membrane receptor structures.
Amine Driouchi, Scott D Gray-Owen, Christopher M Yip

J Biol Chem· October 2022

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Opposing roles of CLK SR kinases in controlling HIV-1 gene expression and latency.
Subha Dahal, Kiera Clayton, Terek Been, Raphaële Fernet-Brochu, Alonso Villasmil Ocando, Scott D Gray-Owen

Retrovirology· August 2022

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upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway.
Camille Martin-Gallausiaux, Diego Garcia-Weber, Amandine Lashermes, Pierre Larraufie, Ludovica Marinelli, Scott D Gray-Owen

Gut Microbes· August 2022

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