Publications by authors named "Scott D Pegan"

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E
Editorial: 5 Years of COVID Research: Highlights from Outbreak to the Present.
Scott D Pegan

ACS Infect Dis· November 2025

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Durable humoral immunity and long-term protection induced by a Crimean-Congo hemorrhagic fever virus replicon particle vaccine in mice.
Teresa E Sorvillo, Elif Karaaslan, Katherine A Davies, Stephen R Welch, Florine E M Scholte, Scott D Pegan

NPJ Vaccines· November 2025

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Crimean-Congo Hemorrhagic Fever Virus Localization and Shedding in the Reproductive Tract of Lethal and Survivor Mouse Models.
Teresa E Sorvillo, Jana M Ritter, Stephen R Welch, Katherine Davies, JoAnn D Coleman-McCray, Scott D Pegan

Emerg Microbes Infect· November 2025

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Rapid, sensitive, and species-independent detection of Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 antibodies.
Elif Karaaslan, Cheng-Feng Chiang, Gülter Öncü Kurutaş, Orçun Barkay, Nesibe Selma Çetin Güler, Scott D Pegan

EBioMedicine· August 2025

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Inflammation associated with monocyte/macrophage activation and recruitment corresponds with lethal outcome in a mouse model of Crimean-Congo haemorrhagic fever.
Teresa E Sorvillo, Jana M Ritter, Stephen R Welch, JoAnn D Coleman-McCray, Katherine A Davies, Scott D Pegan

Emerg Microbes Infect· December 2024

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Crimean Congo hemorrhagic fever virus nucleoprotein and GP38 subunit vaccine combination prevents morbidity in mice.
Elif Karaaslan, Teresa E Sorvillo, Florine E M Scholte, Troy Justin O'Neal, Stephen R Welch, Scott D Pegan

NPJ Vaccines· August 2024

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Evaluation of two inoculation routes of an adenovirus-mediated viral protein inhibitor in a Crimean-Congo hemorrhagic fever mouse model.
Florine E M Scholte, Jessica R Spengler, Stephen R Welch, Jessica R Harmon, JoAnn D Coleman-McCray, Scott D Pegan

Virus Res· July 2024

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Replicon particle vaccination induces non-neutralizing anti-nucleoprotein antibody-mediated control of Crimean-Congo hemorrhagic fever virus.
Teresa E Sorvillo, Elif Karaaslan, Florine E M Scholte, Stephen R Welch, JoAnn D Coleman-McCray, Scott D Pegan

NPJ Vaccines· May 2024

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Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus.
Aura R Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R Cline, Michael D Ward, Scott D Pegan

Nat Commun· February 2024

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Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist.
Parima Udompholkul, Ana Garza-Granados, Giulia Alboreggia, Carlo Baggio, Jack McGuire, Scott D Pegan

J Med Chem· June 2023

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Identifying Drug Candidates for COVID-19 with Large-Scale Drug Screening.
Yifei Wu, Scott D Pegan, David Crich, Lei Lou, Lauren Nicole Mullininx

Int J Mol Sci· February 2023

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Structural characterization of protective non-neutralizing antibodies targeting Crimean-Congo hemorrhagic fever virus.
Ian A Durie, Zahra R Tehrani, Elif Karaaslan, Teresa E Sorvillo, Jack McGuire, Scott D Pegan

Nat Commun· November 2022

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Exploring Noncovalent Protease Inhibitors for the Treatment of Severe Acute Respiratory Syndrome and Severe Acute Respiratory Syndrome-Like Coronaviruses.
Brendan T Freitas, Daniil A Ahiadorme, Rahul S Bagul, Ian A Durie, Samir Ghosh, Scott D Pegan

ACS Infect Dis· March 2022

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The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein.
Justin D Shepard, Brendan T Freitas, Sergio E Rodriguez, Florine E M Scholte, Kailee Baker, Scott D Pegan

Front Immunol· February 2022

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Polyphenols as Potential Inhibitors of SARS-CoV-2 RNA Dependent RNA Polymerase (RdRp).
Yifei Wu, David Crich, Scott D Pegan, Lei Lou, Madelyn C Hansen

Molecules· December 2021

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Polyphenols as alternative treatments of COVID-19.
Yifei Wu, Scott D Pegan, David Crich, Ellison Desrochers, Edward B Starling

Comput Struct Biotechnol J· September 2021

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Losartan Inhibits SARS-CoV-2 Replication in Vitro.
Reza Nejat, Ahmad Shahir Sadr, Branden Freitas, Jackelyn Crabttree, Scott D Pegan

J Pharm Pharm Sci· August 2021

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Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin.
Ian A Durie, John V Dzimianski, Courtney M Daczkowski, Jack McGuire, Kay Faaberg, Scott D Pegan

Acta Crystallogr D Struct Biol· July 2021

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The SARS-CoV-2 SSHHPS Recognized by the Papain-like Protease.
Nathanael D Reynolds, Nathalie M Aceves, Jinny L Liu, Jaimee R Compton, Dagmar H Leary, Scott D Pegan

ACS Infect Dis· June 2021

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Structural and Biochemical Insights into the Inhibition of Human Acetylcholinesterase by G-Series Nerve Agents and Subsequent Reactivation by HI-6.
Jack R McGuire, Stephanie M Bester, Mark A Guelta, Jonah Cheung, Caroline Langley, Scott D Pegan

Chem Res Toxicol· March 2021

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Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis.
John V Dzimianski, Savannah L Mace, Isabelle L Williams, Brendan T Freitas, Scott D Pegan

Acta Crystallogr D Struct Biol· November 2020

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How ISG15 combats viral infection.
Brendan T Freitas, Florine E M Scholte, Éric Bergeron, Scott D Pegan

Virus Res· September 2020

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Characterization and Noncovalent Inhibition of the Deubiquitinase and deISGylase Activity of SARS-CoV-2 Papain-Like Protease.
Brendan T Freitas, Ian A Durie, Jackelyn Murray, Jaron E Longo, Holden C Miller, Scott D Pegan

ACS Infect Dis· August 2020

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Synthesis, Cytotoxicity, and Genotoxicity of 10-Aza-9-oxakalkitoxin, an ,,-Trisubstituted Hydroxylamine Analog, or Hydroxalog, of a Marine Natural Product.
Sandeep Dhanju, Kapil Upadhyaya, Christopher A Rice, Scott D Pegan, Joseph Media

J Am Chem Soc· May 2020

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Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases.
John V Dzimianski, Florine E M Scholte, Isabelle L Williams, Caroline Langley, Brendan T Freitas, Scott D Pegan

PLoS One· April 2020

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