Publications by authors named "Scott Rychnovsky"

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Trioxane-based MS-cleavable cross-linking mass spectrometry for profiling multimeric interactions of cellular networks.
Clinton Yu, Eric Novitsky, Sree Ganesh Balasubramani, Xiaorong Wang, Xiyu Shen, Scott Rychnovsky

Nat Commun· July 2025

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Synthesis of Rhodocorane L Using Gold-Catalyzed Dearomative Spirocyclization.
Emily A Shimizu, Scott D Rychnovsky

Org Lett· June 2025

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Cyclic Osmate Esters from 1,2- and 1,3-Diols and α-Hydroxy Acids for X-ray Analysis.
Jordan C Thompson, Ngoc H Le, Jace Pluemer, Ruby Chen, Charles J Dooley, Scott D Rychnovsky

J Org Chem· February 2025

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Trioxane-based MS-cleavable Cross-linking Mass Spectrometry for Profiling Multimeric Interactions of Cellular Networks.
Clinton Yu, Eric Novitsky, Xiaorong Wang, Ignacia Echeverria, Scott Rychnovsky

bioRxiv· August 2024

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Formation of Chromophores from -Pinonaldehyde Aged in Highly Acidic Conditions.
Cynthia Wong, Jessica E Pazienza, Scott D Rychnovsky, Sergey A Nizkorodov

J Am Chem Soc· May 2024

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Exploring an Alternative Cysteine-Reactive Chemistry to Enable Proteome-Wide PPI Analysis by Cross-Linking Mass Spectrometry.
Fenglong Jiao, Leah J Salituro, Clinton Yu, Craig B Gutierrez, Scott D Rychnovsky

Anal Chem· January 2023

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Discovery of compounds that reactivate p53 mutants in vitro and in vivo.
Geetha Durairaj, Özlem Demir, Bryant Lim, Roberta Baronio, Delia Tifrea, Scott Rychnovsky

Cell Chem Biol· September 2022

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Asymmetric Total Synthesis of (2)-Hydroxynorneomajucin, a Norsesquiterpene from .
Charles J Dooley, Scott D Rychnovsky

Org Lett· May 2022

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Enabling Photoactivated Cross-Linking Mass Spectrometric Analysis of Protein Complexes by Novel MS-Cleavable Cross-Linkers.
Craig Gutierrez, Leah J Salituro, Clinton Yu, Xiaorong Wang, Sadie F DePeter, Scott D Rychnovsky

Mol Cell Proteomics· March 2022

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Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.
Fenglong Jiao, Clinton Yu, Andrew Wheat, Xiaorong Wang, Scott D Rychnovsky

Anal Chem· March 2022

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Total Syntheses of Strasseriolide A and B, Antimalarial Macrolide Natural Products.
Leah J Salituro, Jessica E Pazienza, Scott D Rychnovsky

Org Lett· February 2022

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Protein interaction landscapes revealed by advanced in vivo cross-linking-mass spectrometry.
Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M Burke, Ilan E Chemmama, Scott D Rychnovsky

Proc Natl Acad Sci U S A· August 2021

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Silacycle-Templated Intramolecular Diels-Alder Cyclizations for the Diastereoselective Construction of Complex Carbon Skeletons.
Paul R Carlson, Alexander S Burns, Emily A Shimizu, Shilin Wang, Scott D Rychnovsky

Org Lett· March 2021

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Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode's Acylation Reagents.
Charles J Dooley, Alexander Burtea, Christina Mitilian, Wendy T Dao, Bo Qu, Scott D Rychnovsky

J Org Chem· August 2020

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Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-Containing MS-Cleavable Cross-Linkers.
Clinton Yu, Eric J Novitsky, Nicholas W Cheng, Scott D Rychnovsky, Lan Huang

Anal Chem· April 2020

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Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling.
Craig Gutierrez, Ilan E Chemmama, Haibin Mao, Clinton Yu, Ignacia Echeverria, Scott D Rychnovsky

Proc Natl Acad Sci U S A· February 2020

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Relative and Absolute Structure Assignments of Alkenes Using Crystalline Osmate Derivatives for X-ray Analysis.
Alexander S Burns, Charles Dooley, Paul R Carlson, Joseph W Ziller, Scott D Rychnovsky

Org Lett· December 2019

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Total Synthesis of (-)-Himeradine A.
Alexander Burtea, Jacob DeForest, Xinting Li, Scott D Rychnovsky

Angew Chem Int Ed Engl· November 2019

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Total Synthesis and Structure Revision of (-)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of .
Alexander S Burns, Scott D Rychnovsky

J Am Chem Soc· August 2019

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Probing HO-mediated Structural Dynamics of the Human 26S Proteasome Using Quantitative Cross-linking Mass Spectrometry (QXL-MS).
Clinton Yu, Xiaorong Wang, Alexander Scott Huszagh, Rosa Viner, Eric Novitsky, Scott D Rychnovsky

Mol Cell Proteomics· May 2019

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Biosynthesis-Inspired Approach to Kujounin A Using a Stereoselective Tsuji-Trost Alkylation.
Alexander Burtea, Scott D Rychnovsky

Org Lett· September 2018

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Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies.
Jacob C DeForest, Renzo A Samame, Gregory Suryn, Alexander Burtea, Scott D Rychnovsky

J Org Chem· August 2018

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Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling.
Gilmar A Brito, Franco Della-Felice, Guoshun Luo, Alexander S Burns, Ronaldo A Pilli, Scott D Rychnovsky

Org Lett· July 2018

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Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein-Protein Interactions.
Craig B Gutierrez, Sarah A Block, Clinton Yu, Stephanie M Soohoo, Alexander S Huszagh, Scott D Rychnovsky

Anal Chem· June 2018

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Heteroatom-Directed Acylation of Secondary Alcohols To Assign Absolute Configuration.
Alexander S Burns, Christopher C Ross, Scott D Rychnovsky

J Org Chem· March 2018

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