Publications by authors named "Sean C Shadle"

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Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program.
Christina M Smith, Edward J Grow, Sean C Shadle, Bradley R Cairns

bioRxiv· June 2023

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p53 convergently activates Dux/DUX4 in embryonic stem cells and in facioscapulohumeral muscular dystrophy cell models.
Edward J Grow, Bradley D Weaver, Christina M Smith, Jingtao Guo, Paula Stein, Sean C Shadle

Nat Genet· August 2021

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DUX4-induced bidirectional HSATII satellite repeat transcripts form intranuclear double-stranded RNA foci in human cell models of FSHD.
Sean C Shadle, Sean R Bennett, Chao-Jen Wong, Nancy A Karreman, Amy E Campbell

Hum Mol Genet· December 2019

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DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade.
Guo-Liang Chew, Amy E Campbell, Emma De Neef, Nicholas A Sutliff, Sean C Shadle

Dev Cell· September 2019

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Facioscapulohumeral dystrophy: activating an early embryonic transcriptional program in human skeletal muscle.
Amy E Campbell, Andrea E Belleville, Rebecca Resnick, Sean C Shadle, Stephen J Tapscott

Hum Mol Genet· August 2018

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NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins.
Amy E Campbell, Sean C Shadle, Sujatha Jagannathan, Jong-Won Lim, Rebecca Resnick

Elife· March 2018

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BET bromodomain inhibitors and agonists of the beta-2 adrenergic receptor identified in screens for compounds that inhibit DUX4 expression in FSHD muscle cells.
Amy E Campbell, Jonathan Oliva, Matthew P Yates, Jun Wen Zhong, Sean C Shadle

Skelet Muscle· September 2017

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DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy.
Sean C Shadle, Jun Wen Zhong, Amy E Campbell, Melissa L Conerly, Sujatha Jagannathan

PLoS Genet· March 2017

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Model systems of DUX4 expression recapitulate the transcriptional profile of FSHD cells.
Sujatha Jagannathan, Sean C Shadle, Rebecca Resnick, Lauren Snider, Rabi N Tawil

Hum Mol Genet· October 2016

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