Publications by authors named "Sean D Simpson"

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Addendum: Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale.
Fungmin Eric Liew, Robert Nogle, Tanus Abdalla, Blake J Rasor, Christina Canter, Séan D Simpson

Nat Biotechnol· August 2025

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Dos and don'ts for scaling up gas fermentations.
Lars Puiman, Carolin Bokelmann, Sean D Simpson, Alfred M Spormann, Ralf Takors

Curr Opin Biotechnol· June 2025

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Autotrophic adaptive laboratory evolution of the acetogen Clostridium autoethanogenum delivers the gas-fermenting strain LAbrini with superior growth, products, and robustness.
Henri Ingelman, James K Heffernan, Audrey Harris, Steven D Brown, Kurshedaktar Majibullah Shaikh, Séan D Simpson

N Biotechnol· November 2024

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An alcove at the acetyl-CoA synthase nickel active site is required for productive substrate CO binding and anaerobic carbon fixation.
Seth Wiley, Claire Griffith, Peter Eckert, Alexander P Mueller, Robert Nogle, Séan D Simpson

J Biol Chem· August 2024

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Phylogenomics and genetic analysis of solvent-producing Clostridium species.
Rasmus O Jensen, Frederik Schulz, Simon Roux, Dawn M Klingeman, Wayne P Mitchell, Séan D Simpson

Sci Data· May 2024

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isopropanol production native plasmid pCA replicon.
Robert Nogle, Shilpa Nagaraju, Sagar M Utturkar, Richard J Giannone, Vinicio Reynoso, Sean D Simpson

Front Bioeng Biotechnol· August 2022

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Cell-free prototyping enables implementation of optimized reverse β-oxidation pathways in heterotrophic and autotrophic bacteria.
Bastian Vögeli, Luca Schulz, Shivani Garg, Katia Tarasava, James M Clomburg, Sean D Simpson

Nat Commun· June 2022

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Required Gene Set for Autotrophic Growth of .
Craig Woods, Christopher M Humphreys, Claudio Tomi-Andrino, Anne M Henstra, Michael Köpke, Sean D Simpson

Appl Environ Microbiol· April 2022

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Absolute Proteome Quantification in the Gas-Fermenting Acetogen .
Kaspar Valgepea, Gert Talbo, Nobuaki Takemori, Ayako Takemori, Christina Ludwig, Séan Dennis Simpson

mSystems· April 2022

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Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale.
Fungmin Eric Liew, Robert Nogle, Tanus Abdalla, Blake J Rasor, Christina Canter, Séan D Simpson

Nat Biotechnol· March 2022

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Stepping on the Gas to a Circular Economy: Accelerating Development of Carbon-Negative Chemical Production from Gas Fermentation.
Nick Fackler, Björn D Heijstra, Blake J Rasor, Hunter Brown, Jacob Martin, Séan D Simpson

Annu Rev Chem Biomol Eng· June 2021

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Transcriptional control of using CRISPRi.
Nicholas Fackler, James Heffernan, Alex Juminaga, Damien Doser, Shilpa Nagaraju, Séan D Simpson

Synth Biol (Oxf)· February 2021

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Development of a clostridia-based cell-free system for prototyping genetic parts and metabolic pathways.
Antje Krüger, Alexander P Mueller, Grant A Rybnicky, Nancy L Engle, Zamin K Yang, Sean D Simpson

Metab Eng· November 2020

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Pollution to products: recycling of 'above ground' carbon by gas fermentation.
Michael Köpke, Séan D Simpson

Curr Opin Biotechnol· October 2020

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Modular cell-free expression plasmids to accelerate biological design in cells.
Ashty S Karim, Fungmin Eric Liew, Shivani Garg, Bastian Vögeli, Blake J Rasor, Séan D Simpson

Synth Biol (Oxf)· October 2020

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In vitro prototyping and rapid optimization of biosynthetic enzymes for cell design.
Ashty S Karim, Quentin M Dudley, Alex Juminaga, Yongbo Yuan, Samantha A Crowe, Sean D Simpson

Nat Chem Biol· August 2020

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Redox controls metabolic robustness in the gas-fermenting acetogen .
Vishnuvardhan Mahamkali, Kaspar Valgepea, Renato de Souza Pinto Lemgruber, Manuel Plan, Ryan Tappel, Séan Dennis Simpson

Proc Natl Acad Sci U S A· June 2020

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Enhancing CO-Valorization Using for Sustainable Fuel and Chemicals Production.
James K Heffernan, Kaspar Valgepea, Renato de Souza Pinto Lemgruber, Isabella Casini, Manuel Plan, Sean D Simpson

Front Bioeng Biotechnol· March 2020

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A TetR-Family Protein (CAETHG_0459) Activates Transcription From a New Promoter Motif Associated With Essential Genes for Autotrophic Growth in Acetogens.
Renato de Souza Pinto Lemgruber, Kaspar Valgepea, Ricardo Axayacatl Gonzalez Garcia, Christopher de Bakker, Robin William Palfreyman, Séan Dennis Simpson

Front Microbiol· November 2019

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A novel conjugal donor strain for improved DNA transfer into Clostridium spp.
Craig Woods, Christopher M Humphreys, Raquel Mesquita Rodrigues, Patrick Ingle, Peter Rowe, Sean D Simpson

Anaerobe· October 2019

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The carbonic anhydrase of Clostridium autoethanogenum represents a new subclass of β-carbonic anhydrases.
Bart Pander, Gemma Harris, David J Scott, Klaus Winzer, Michael Köpke, Sean D Simpson

Appl Microbiol Biotechnol· September 2019

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Engineering of vitamin prototrophy in Clostridium ljungdahlii and Clostridium autoethanogenum.
Florence J Annan, Bakir Al-Sinawi, Christopher M Humphreys, Rupert Norman, Klaus Winzer, Sean D Simpson

Appl Microbiol Biotechnol· June 2019

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Systems-level engineering and characterisation of Clostridium autoethanogenum through heterologous production of poly-3-hydroxybutyrate (PHB).
Renato de Souza Pinto Lemgruber, Kaspar Valgepea, Ryan Tappel, James B Behrendorff, Robin William Palfreyman, Séan Dennis Simpson

Metab Eng· May 2019

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H drives metabolic rearrangements in gas-fermenting .
Kaspar Valgepea, Renato de Souza Pinto Lemgruber, Tanus Abdalla, Steve Binos, Nobuaki Takemori, Séan Dennis Simpson

Biotechnol Biofuels· March 2018

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Quantitative analysis of tetrahydrofolate metabolites from clostridium autoethanogenum.
Renato de Souza Pinto Lemgruber, Kaspar Valgepea, Mark P Hodson, Ryan Tappel, Sean D Simpson

Metabolomics· February 2018

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